Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stephanie H. Cholensky"'
Autor:
Kelsey N. Lamb, Sarah N. Dishman, Jarod M. Waybright, Isabelle A. Engelberg, Justin M. Rectenwald, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kenneth H. Pearce, Lindsey I. James, Stephen V. Frye
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 716-732 (2021)
Externí odkaz:
https://doaj.org/article/80ec6b26fa154dc6ae4b514e28795b9f
Autor:
Justin M. Rectenwald, Shiva Krishna Reddy Guduru, Zhao Dang, Leonard B. Collins, Yi-En Liao, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kyle W. Kaufmann, Scott M. Hammond, Dmitri B. Kireev, Stephen V. Frye, Kenneth H. Pearce
Publikováno v:
Molecules, Vol 25, Iss 4, p 979 (2020)
Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for ot
Externí odkaz:
https://doaj.org/article/befc2b9a6ae44e7dbdde672ada128d9b
Autor:
Frances M. Bashore, Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Christine A. Mills, Kenneth H. Pearce, Laura E. Herring, Dmitri Kireev, Stephen V. Frye, Lindsey I. James
Publikováno v:
ACS Chemical Biology. 18:494-507
Autor:
Kenneth H. Pearce, Sarah E. Clinkscales, Justin M. Rectenwald, Anna M. Chiarella, Jarod Waybright, Jacqueline Norris-Drouin, Kimberly D. Barnash, Gabrielle R Budziszewski, Laura E. Herring, Robert K. McGinty, Lindsey I. James, Stephanie H. Cholensky, Nathaniel A. Hathaway
Publikováno v:
ACS Chem Biol
The interpretation of histone post-translational modifications (PTMs), specifically lysine methylation, by specific classes of “reader” proteins marks an important aspect of epigenetic control of gene expression. Methyl-lysine (Kme) readers often
Autor:
Utkarsh Tripathi, Mark Pierson, Paul D. Robbins, Nino Giorgadze, James L. Kirkland, David B. Allison, Tamara Tchkonia, Stephen C. Jameson, Sara E. Hamilton, Larissa G.P. Langhi Prata, Christina L. Inman, Stephanie H. Cholensky, Lei Zhang, Elizabeth J. Atkinson, Ming Li, Yi Zhu, Christina D. Camell, Jair Machado Espindola-Netto, Laura J. Niedernhofer, Tamar Pirtskhalava, Matthew A. Huggins, Alexander Meves, Matthew J. Yousefzadeh, Sundeep Khosla, Keisuke Ejima, Sergio E. Chiarella, Y. S. Prakash, M. Gerard O'Sullivan, Ryan D. O’Kelly, Nathan K. LeBrasseur, Timothy W. Carlson, Pengcheng Xun, Kurt O. Johnson, Ailing Xue
Publikováno v:
Science (New York, N.Y.)
INTRODUCTION: The COVID-19 pandemic revealed enhanced vulnerability of the elderly and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Senescence is a cell fate elicited by cellular str
Autor:
Stephen V. Frye, Isabelle A. Engelberg, Stephanie H. Cholensky, Jiuyang Liu, Tatiana G. Kutateladze, Jacqueline Norris-Drouin, Samantha A Ottavi, Lindsey I. James
Publikováno v:
J Med Chem
Plant homeodomain finger protein 1 (PHF1) is an accessory component of the gene silencing complex polycomb repressive complex 2 and recognizes the active chromatin mark, trimethylated lysine 36 of histone H3 (H3K36me3). In addition to its role in tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe538c536e9133086e1eccee9611eb81
https://europepmc.org/articles/PMC8225578/
https://europepmc.org/articles/PMC8225578/
Autor:
Daniel Bsteh, Shivani Soni, Heather Ogana, Heinz-Josef Lenz, Stephen V. Frye, Stephanie H. Cholensky, Justin M. Rectenwald, Yibo Si, Oliver Bell, Jacqueline L. Norris, Junghyun L. Suh, Lindsey I. James, Tyler M. Weaver, Jessica D. Umana, Dmitri Kireev, Yong-Mi Kim, Bryce Hart, Shannon M. Mumenthaler, Brian Hardy, Cari A. Sagum, Catherine A. Musselman, Roy Lau, Gang Greg Wang, Dongxu Li, Ken H. Pearce, Mark T. Bedford, Carina Pribitzer
Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041c17c959746d5da4e46faee689c326
https://doi.org/10.1101/2021.02.23.432388
https://doi.org/10.1101/2021.02.23.432388
Autor:
Andre S. Godoy, Victoria A Haberman, Ana C. Puhl, Leslie V. Parise, Jacob E. Larson, Stephen V. Frye, Jonathan W. Bogart, Kenneth H. Pearce, Tina M. Leisner, Jacqueline Norris-Drouin, Stephanie H. Cholensky, Albert A. Bowers
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ACS Chem Biol
Universidade de São Paulo (USP)
instacron:USP
ACS Chem Biol
Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs tumor growth in tripl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260d717507541df8df0aa4ad214c4937
Autor:
Justin M. Rectenwald, Stephanie H. Cholensky, Lindsey I. James, Kenneth H. Pearce, Stephen V. Frye, P Brian Hardy, Jacqueline Norris-Drouin
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(6)
Chromatin regulatory complexes localize to specific sites via recognition of posttranslational modifications (PTMs) on N-terminal tails of histone proteins (e.g., methylation, acetylation, and phosphorylation). Molecular recognition of modified histo
Autor:
Kelsey N. Lamb, Daniel Bsteh, Stephen V. Frye, Hagar F. Moussa, Lindsey I. James, Sarah N. Dishman, Jacob I. Stuckey, Benjamin Z. Stanton, Huitao Fan, Jacqueline L. Norris, Dongxu Li, Mark T. Bedford, Cari A. Sagum, Terry P. Kenakin, Dmitri Kireev, Gang Greg Wang, Oliver Bell, Jingkui Wang, Stephanie H. Cholensky
Publikováno v:
SSRN Electronic Journal
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM), UNC4976, of nucleic acid bi