Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephanie Guzik-Lendrum"'
Publikováno v:
J Biol Chem
Heterodimeric kinesin family member KIF3AC is a mammalian kinesin-2 that is highly expressed in the central nervous system and has been implicated in intracellular transport. KIF3AC is unusual in that the motility characteristics of KIF3C when expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411e831a7cd8537f6519c89f8d472c04
https://doi.org/10.1074/jbc.ra119.010725
https://doi.org/10.1074/jbc.ra119.010725
Autor:
Roderic G. Eckenhoff, Susan P. Gilbert, William P. Dailey, Kellie A. Woll, Brandon M. Bensel, Benjamin A. Garcia, Stephanie Guzik-Lendrum, Natarajan V. Bhanu
Publikováno v:
The Journal of Biological Chemistry
Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531466032d3dc18c234e942ba3900fc0
https://doi.org/10.1074/jbc.ra118.002182
https://doi.org/10.1074/jbc.ra118.002182
Publikováno v:
Journal of Biological Chemistry. 293:4510-4518
Kinesin-2s are major transporters of cellular cargoes. This subfamily contains both homodimeric kinesins whose catalytic domains result from the same gene product and heterodimeric kinesins with motor domains derived from two different gene products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3549c0c29e9b9e5fe7515b3295d54440
https://doi.org/10.1074/jbc.r117.001324
https://doi.org/10.1074/jbc.r117.001324
Publikováno v:
Biophysical journal. 113(8)
KIF3C is one subunit of the functional microtubule-based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons. However, KIF3C has also been implicated as an injury-specific kinesin that is a key regulator of axonal growth and regenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f04af4629462c643e504d7511b0a1e
https://pubmed.ncbi.nlm.nih.gov/29045878
https://pubmed.ncbi.nlm.nih.gov/29045878
Autor:
Roderic G. Eckenhoff, Kellie A. Woll, Stephanie Guzik-Lendrum, Erin M Masucci, Susan P. Gilbert, Brandon M. Bensel
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Propofol is the most widely used i.v. general anesthetic to induce and maintain anesthesia. It is now recognized that this small molecule influences ligand-gated channels, including the GABAA receptor and others. Specific propofol binding sites have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e02d2770d07ba84f203bba31a731594
https://doi.org/10.1073/pnas.1701482114
https://doi.org/10.1073/pnas.1701482114
Publikováno v:
The Journal of biological chemistry. 291(44)
Mammalian KIF3AB is an N-terminal processive kinesin-2 that is best known for its roles in intracellular transport. There has been significant interest in KIF3AB to define the key principles that underlie its processivity but also to define the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141fc455195a99a07de2a431e9380f70
https://pubmed.ncbi.nlm.nih.gov/27637334
https://pubmed.ncbi.nlm.nih.gov/27637334
Publikováno v:
The Journal of Biological Chemistry
The gene encoding Drosophila myosin-18 is complex and can potentially yield six alternatively spliced mRNAs. One of the major features of this myosin is an N-terminal PDZ domain that is included in some of the predicted alternatively spliced products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a6c07703ffe0c18e0f9d3f25e1a291
https://doi.org/10.1074/jbc.m111.218669
https://doi.org/10.1074/jbc.m111.218669
Autor:
Katherine C. Rank, Ivan Rayment, Brandon M. Bensel, Stephanie Guzik-Lendrum, Susan P. Gilbert
Publikováno v:
Biophysical Journal. 108:21a
Mammalian KIF3AC is a heterotrimeric kinesin-2 that is best known for roles in organelle transport and remodeling of the microtubule cytoskeleton in neuronal tissue, yet in vitro studies to characterize its single molecule behavior are lacking. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3beedb5fb8cdf0afe20dcafc077995
https://doi.org/10.1016/j.bpj.2014.11.139
https://doi.org/10.1016/j.bpj.2014.11.139
Autor:
Yingfan Zhang, James R. Sellers, Kirsten Remmert, Dong Li, Eric Betzig, John A. Hammer, Yasuharu Takagi, Neil Billington, Lin Shao, Melanie Barzik, Stephanie Guzik-Lendrum, Jordan R. Beach, Yi Yang, Sarah M. Heissler, Attila Nagy
Publikováno v:
Curr Biol
SummaryClass-18 myosins are most closely related to conventional class-2 nonmuscle myosins (NM2). Surprisingly, the purified head domains of Drosophila, mouse, and human myosin 18A (M18A) lack actin-activated ATPase activity and the ability to transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed466e9894eccf3b97fde75c017d0b7
Autor:
Keenan C. Taylor, Ivan Rayment, Susan P. Gilbert, Katherine C. Rank, Stephanie Guzik-Lendrum, Brandon M. Bensel
Publikováno v:
Biophysical Journal. (7):1472-1482
Mammalian KIF3AC is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons, yet in vitro studies to characterize its single molecule behavior are lacking. The results presented show that a KIF3AC motor that inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4f2d83ad054e59b2ea96ea29b893e2