Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Stephanie Gras"'
Autor:
Demetra S.M. Chatzileontiadou, Christian A. Lobos, Hayden Robson, Coral-Ann Almedia, Christopher Szeto, Alison Castley, Lloyd J. D’Orsogna, Stephanie Gras
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114555- (2024)
Summary: HIV controllers can control viral replication and remain healthy, but the mechanism behind this control is unknown. Despite human leukocyte antigen (HLA) diversity in the population, almost 50% of HIV controllers express the HLA-B∗57:01 mo
Externí odkaz:
https://doaj.org/article/132eb11625684b04becdf44331b5fdb1
Autor:
Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Objectives Seasonal influenza viruses cause roughly 650 000 deaths annually despite available vaccines. CD8+ T cells typically recognise influenza‐derived peptides from internal structural and non‐structural influenza proteins and are an
Externí odkaz:
https://doaj.org/article/92b22af77c7e4591a45e894d639392e0
Autor:
You Min Ahn, Janesha C. Maddumage, Emma J. Grant, Demetra S.M. Chatzileontiadou, W.W.J. Gihan Perera, Brian M. Baker, Christopher Szeto, Stephanie Gras
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100148- (2024)
CD8+ T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural protein th
Externí odkaz:
https://doaj.org/article/8532197134a44c818e511779c5cc34a4
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 2, Pp n/a-n/a (2024)
Abstract Seasonal influenza viruses continue to cause severe medical and financial complications annually. Although there are many licenced influenza vaccines, there are billions of cases of influenza infection every year, resulting in the death of o
Externí odkaz:
https://doaj.org/article/0f03683b38464fcaacd194674c90963a
Autor:
Srividhya Swaminathan, Katie E. Lineburg, Archana Panikkar, Jyothy Raju, Lawton D. Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J. Dewar-Oldis, Peter J. Barnard, George R. Ambalathingal, Michelle A. Neller, Kirsty R. Short, Stephanie Gras, Rajiv Khanna, Corey Smith
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
The T cell response to SARS-CoV-2 is important in protection from infection. Here the authors show by concentrating on a specific HLA haplotype that mutations in SARS-CoV-2 as new variants emerge can affect T cell recognition and reduce T cell respon
Externí odkaz:
https://doaj.org/article/0cdd1d591de84863bb6c9e35da19a9b1
Autor:
Christopher Szeto, Pirooz Zareie, Rushika C. Wirasinha, Justin B. Zhang, Andrea T. Nguyen, Alan Riboldi-Tunnicliffe, Nicole L. La Gruta, Stephanie Gras, Stephen R. Daley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Differentiation and activation of T cells are normally modulated by non-covalent interactions between T cell receptor (TCR) and antigenic peptides. Here the authors use step-wise mutations, biochemical characterization and structural insights to desc
Externí odkaz:
https://doaj.org/article/7e92a31da92d45c4ae21ba3f6d5114af
Autor:
Marcus ZW Tong, Julian DJ Sng, Meagan Carney, Lucy Cooper, Samuel Brown, Katie E Lineburg, Keng Yih Chew, Neve Collins, Kirsten Ignacio, Megan Airey, Lucy Burr, Briony A Joyce, Dhilshan Jayasinghe, Christopher LD McMillan, David A Muller, Anurag Adhikari, Linda A Gallo, Emily S Dorey, Helen L Barrett, Stephanie Gras, Corey Smith, Kim Good‐Jacobson, Kirsty R Short
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Objective Class III obesity (body mass index [BMI] ≥ 40 kg m−2) significantly impairs the immune response to SARS‐CoV‐2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m−2) on humoral immunity to SARS‐CoV‐2 infec
Externí odkaz:
https://doaj.org/article/656608753bfc4d1498ed16cc174b0aab
Autor:
Cilia R Pothast, Romy C Dijkland, Melissa Thaler, Renate S Hagedoorn, Michel GD Kester, Anne K Wouters, Pieter S Hiemstra, Martijn J van Hemert, Stephanie Gras, JH Frederik Falkenburg, Mirjam HM Heemskerk
Publikováno v:
eLife, Vol 11 (2022)
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4+ and CD8+ T cells in SARS-CoV-2-unexposed donors has been explained by the presence of T cells primed by other coronaviruses. However, based on the relatively high
Externí odkaz:
https://doaj.org/article/647bdbd851504164827c41c2ee7c4dee
Autor:
Emma J. Grant, Stephanie Gras
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101590- (2022)
Summary: Directly ex vivo, peptide-specific CD8+ T cells are present at relatively low frequency and are typically in a resting state. This protocol details the expansion of memory peptide-specific CD8+ T cells by in vitro stimulation, which can be s
Externí odkaz:
https://doaj.org/article/a4f7a23559f846b09ae30556dc4102c9
Autor:
Andrea T. Nguyen, Christopher Szeto, Dhilshan Jayasinghe, Christian A. Lobos, Hanim Halim, Demetra S. M. Chatzileontiadou, Emma J. Grant, Stephanie Gras
Publikováno v:
Biophysica, Vol 1, Iss 2, Pp 194-203 (2021)
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease sever
Externí odkaz:
https://doaj.org/article/cf3da1f68d4a451a9513421d801902a3