Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stephanie Grabow"'
Autor:
Stephanie Grabow, Alex R.D. Delbridge, Brandon J. Aubrey, Cassandra J. Vandenberg, Andreas Strasser
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2337-2347 (2016)
MCL-1 is critical for progenitor cell survival during emergency hematopoiesis, but its role in sustaining cells undergoing transformation and in lymphomagenesis is only poorly understood. We investigated the importance of MCL-1 in the survival of B l
Externí odkaz:
https://doaj.org/article/76b0c419d08040e1890362fe9728cf06
Autor:
Sayeda Yasmin-Karim, Patrick T. Bruck, Michele Moreau, Sijumon Kunjachan, Gui Zhen Chen, Rajiv Kumar, Stephanie Grabow, Stephanie K. Dougan, Wilfred Ngwa
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an in situ vaccine. In practice, this abscopal effect is rarely observed. We use tw
Externí odkaz:
https://doaj.org/article/8bc9c7834edf4d2ea66ab26f3602bfc8
Autor:
Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3285-3295.e4 (2018)
Summary: Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. A
Externí odkaz:
https://doaj.org/article/b958c8def9dc4e4eb7387f18421e59a4
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Supplemental figures 1, 2, and 3 and supplemental tables 1 and 2, showing the antitumor activity of EphA2-ILS-DTXp and the pharmacokinetics in multiple murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc53494c662779c87e655ae0c6423c80
https://doi.org/10.1158/1535-7163.22509429
https://doi.org/10.1158/1535-7163.22509429
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2072df5200a5c5f8144cbc7a5091df
https://doi.org/10.1158/1535-7163.c.6539295.v1
https://doi.org/10.1158/1535-7163.c.6539295.v1
Autor:
Diane Moujalled, Adam G. Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I. Bush, Andreas Strasser
Publikováno v:
Cell Death Differ
Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer, with treatment options often constrained due to inherent resistance of malignant cells to conventional therapy. We investigated the impact of triggering programmed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1620f50e95c6a712a74376c234d324ec
https://europepmc.org/articles/PMC9287558/
https://europepmc.org/articles/PMC9287558/
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Gang Sun, Vasileios Askoxylakis, Lia Luus, Ross B. Fulton, James F. Sampson, Eric M. Tam, Andrew J. Sawyer, Zhaohua Richard Huang, Daryl C. Drummond, Anne-Sophie Dugast, Michael Santiago, James Suchy, Stephanie Grabow
Publikováno v:
Molecular Cancer Therapeutics. 19:270-281
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d1de2be371c87bef464a4ffd8c4529
https://doi.org/10.1158/1535-7163.mct-19-0414
https://doi.org/10.1158/1535-7163.mct-19-0414
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e94f819de7e7f6ccdf49b01d0fee2
https://doi.org/10.1038/s41551-019-0385-4
https://doi.org/10.1038/s41551-019-0385-4
Autor:
Stephanie Grabow, Lachlan Whitehead, Stefan P Glaser, Verena C. Wimmer, Alex R. D. Delbridge, Ian M. Smyth, Ming Shen Tham, Andreas Strasser, Marco J Herold, Kerstin Brinkmann, Denny L Cottle, Duong Nhu, Guillaume Lessene, Paul Waring, Gemma L. Kelly
Publikováno v:
EMBO J
Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, little is known about the role(s) of these proteins in adults in response to cytotoxic stresses, such as treatment with ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d646b2b2367bdbabef781d7b1d258cd6
https://europepmc.org/articles/PMC7737616/
https://europepmc.org/articles/PMC7737616/
Autor:
Alex R. D. Delbridge, Verena Wimmer, Andreas Strasser, Gemma L. Kelly, Stefan P Glaser, Guillaume Lessene, Lachlan Whitehead, Kerstin Brinkmann, Stephanie Grabow, Duong Nhu, Marco J Herold, Paul Waring
Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis, but less is known about the roles of these proteins in adults, including in the response to cytotoxic stresses, such as treatment wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c86f0ff27a05bc61d1da10dddb1990
https://doi.org/10.1101/2020.04.28.055665
https://doi.org/10.1101/2020.04.28.055665