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of 7
pro vyhledávání: '"Stephanie Friedrichs"'
Autor:
Hendrik Lapp, Tobias Bruegmann, Daniela Malan, Stephanie Friedrichs, Carsten Kilgus, Alexandra Heidsieck, Philipp Sasse
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c8f177fcac3a40ffa5291c2c4d6dde26
Publikováno v:
Journal of Clinical Medicine, Vol 4, Iss 1, Pp 102-123 (2015)
Disease-specific induced pluripotent stem (iPS) cells can be generated from patients and differentiated into functional cardiomyocytes for characterization of the disease and for drug screening. In order to obtain pure cardiomyocytes for automated el
Externí odkaz:
https://doaj.org/article/0f1dc6d0b9734b58b6f100a177282dae
Autor:
Alexandra Heidsieck, Hendrik Lapp, Carsten Kilgus, Stephanie Friedrichs, Daniela Malan, Tobias Bruegmann, Philipp Sasse
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Alexandra Heidsieck, Tobias Bruegmann, Carsten Kilgus, Hendrik Lapp, Stephanie Friedrichs, Philipp Sasse, Daniela Malan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Side effects on cardiac ion channels are one major reason for new drugs to fail during preclinical evaluation. Herein we propose a simple optogenetic screening tool measuring extracellular field potentials (FP) from paced cardiomyocytes to identify d
Publikováno v:
Journal of Clinical Medicine, Vol 4, Iss 1, Pp 102-123 (2015)
Journal of Clinical Medicine; Volume 4; Issue 1; Pages: 102-123
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 4; Issue 1; Pages: 102-123
Journal of Clinical Medicine
Disease-specific induced pluripotent stem (iPS) cells can be generated from patients and differentiated into functional cardiomyocytes for characterization of the disease and for drug screening. In order to obtain pure cardiomyocytes for automated el
Publikováno v:
Trends in Cardiovascular Medicine. 23:91-98
Long QT syndromes (LQTS) are a family of inherited monogenetic disorders caused by gain or loss-of-function mutations of cardiac ion channels and are characterized by a prolonged QT interval in the ECG. The disease-specific mutations lead to prolonge
Publikováno v:
Circulation Research
Circulation Research; Vol 109
Circulation Research; Vol 109
Rationale: Current approaches for the investigation of long-QT syndromes (LQTS) are mainly focused on identification of the mutation and its characterization in heterologous expression systems. However, it would be extremely helpful to be able to cha