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Autor:
Stephanie Faelens, Norbert Bakalara, Erin Broderick, Julian M. W. Chan, Evangelia Kotsikorou, Roberto Docampo, Yongcheng Song, Eric Oldfield, Zev Tovian
Publikováno v:
Journal of Medicinal Chemistry. 48:6128-6139
Trypanosoma brucei, the causative agent of African trypanosomiasis, contains a soluble, vacuolar pyrophosphatase, TbVSP1, not present in humans, which is essential for the growth of bloodstream forms in their mammalian host. Here, we report the inhib