Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephanie Everingham"'
Autor:
Andrew W.B. Craig, John S. Allingham, Peter A. Greer, Shengnan Zhang, Stephanie Everingham, Ester Kwok
AVI file - 24K, BMMCs from fes+/+ and fes-/- mice were loaded with CellTracker green or CellTracker orange, respectively, prior to mixing and addition to fibronectin-coated coverslips with an SCF-embedded agarose drop. Time lapse microscopy was then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75068e7ff459dc9c2991700227059e31
https://doi.org/10.1158/1541-7786.22516828
https://doi.org/10.1158/1541-7786.22516828
Autor:
Andrew W.B. Craig, John S. Allingham, Peter A. Greer, Shengnan Zhang, Stephanie Everingham, Ester Kwok
KIT receptor is required for mast cell development, survival, and migration toward its ligand stem cell factor (SCF). Many solid tumors express SCF and this leads to mast cell recruitment to tumors and release of mediators linked to tumor angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::761f12c6e91efee28d92a5981376bd57
https://doi.org/10.1158/1541-7786.c.6541507
https://doi.org/10.1158/1541-7786.c.6541507
Autor:
Stephanie Everingham, Namit Sharma, Zhong Yin Zhang, Reuben Kapur, Andrew W.B. Craig, Li-Fan Zeng
Publikováno v:
Oncotarget
Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751e0cda02f9742b220b13f651c654b0
https://doi.org/10.18632/oncotarget.2177
https://doi.org/10.18632/oncotarget.2177
Publikováno v:
The Journal of Immunology. 192:4859-4866
SHP2 protein–tyrosine phosphatase (encoded by Ptpn11) positively regulates KIT (CD117) signaling in mast cells and is required for mast cell survival and homeostasis in mice. In this study, we uncover a role of SHP2 in promoting chemotaxis of mast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ecb56ed7c23a91786dfe1e3d31a816
https://doi.org/10.4049/jimmunol.1301155
https://doi.org/10.4049/jimmunol.1301155
Publikováno v:
European Journal of Immunology. 44:831-841
Activation of the innate immune system is critical for clearance of bacterial pathogens to limit systemic infections and host tissue damage. Here, we report a key role for calpain proteases in bacterial clearance in mice with acute peritonitis. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed5ca0996d3b3b0674f6ffdd7f157836
https://doi.org/10.1002/eji.201343757
https://doi.org/10.1002/eji.201343757
Autor:
Raghuveer Singh Mali, Andrew W.B. Craig, Reuben Kapur, Namit Sharma, Zhong Yin Zhang, Karin Hartmann, Gen-Sheng Feng, Vijay Kumar, Li-Fan Zeng, Stephanie Everingham, Axel Roers
Publikováno v:
Molecular and Cellular Biology. 32:2653-2663
Mast cells require KIT receptor tyrosine kinase signaling for development and survival. Here, we report that SH2 domain-containing phosphatase 2 (SHP2) signaling downstream of KIT is essential for mast cell survival and homeostasis in mice. Using a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290a460cdc5aec3ff6e4e3609bc098dc
https://doi.org/10.1128/mcb.00308-12
https://doi.org/10.1128/mcb.00308-12
Autor:
Ester Kwok, Andrew W.B. Craig, Flavia Troglio, Jinghui Hu, Alka Mukhopadhyay, Giorgio Scita, Stephanie Everingham
Publikováno v:
Cellular Signalling. 21:1686-1697
Cdc42-Interacting Protein-4 (CIP4) family adaptors have been implicated in promoting Epidermal Growth Factor Receptor (EGFR) internalization, however, their unique or overlapping functions remain unclear. Here, we show that although CIP4 was not requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1929d1a266120859a1dd63617908be9
https://doi.org/10.1016/j.cellsig.2009.07.007
https://doi.org/10.1016/j.cellsig.2009.07.007
Autor:
Namit Sharma, Andrew W.B. Craig, Stephanie Everingham, Victor A. McPherson, Julie A. Smith, Gen-Sheng Feng, Helen He Zhu
Publikováno v:
The Journal of Immunology. 183:4940-4947
Clustering of the high affinity IgE receptor (Fc(epsilon)RI) in mast cells leads to degranulation and production of numerous cytokines and lipid mediators that promote allergic inflammation. Initiation of FFc(epsilon)RI signaling involves rapid tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b849cd1b1bd92b50906806e622328544
https://doi.org/10.4049/jimmunol.0900702
https://doi.org/10.4049/jimmunol.0900702
Autor:
Heather Ramshaw, Martin Petkovich, Mohammed Taimi, Glenville Jones, Stephanie Everingham, Shui-Pang Tam, Jay A. White, Wayne A. Stangle, Shelly Creighton, Anqi Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 97:6403-6408
Retinoids, particularly all- trans -retinoic acid (RA), are potent regulators of cell differentiation, cell proliferation, and apoptosis. The role of all- trans -RA during development and in the maintenance of adult tissues has been well established.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041440e1563ba09b04fbf8ec732be67
https://doi.org/10.1073/pnas.120161397
https://doi.org/10.1073/pnas.120161397
Autor:
Shengnan Zhang, Ester Kwok, John S. Allingham, Andrew W.B. Craig, Peter A. Greer, Stephanie Everingham
Publikováno v:
Molecular cancer research : MCR. 10(7)
KIT receptor is required for mast cell development, survival, and migration toward its ligand stem cell factor (SCF). Many solid tumors express SCF and this leads to mast cell recruitment to tumors and release of mediators linked to tumor angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e76ca8fd2ef78ef49e2fb7ba44d29b
https://pubmed.ncbi.nlm.nih.gov/22589410
https://pubmed.ncbi.nlm.nih.gov/22589410