Výsledky vyhledávání - "Stephanie E.J. Cronin"

Twenty-four hour ex-vivo normothermic machine perfusion in rat livers

Autor: Korkut Uygun, Heidi Yeh, James F. Markmann, Omar J. Haque, Siavash Raigani, Stephanie E.J. Cronin, Casie A. Pendexter, Reiner J de Vries

Publikováno v: Technology (Singap World Sci)

Ex-vivo liver perfusion (EVLP) is an ideal platform to study liver disease, therapeutic interventions, and pharmacokinetic properties of drugs without any patient risk. Rat livers are an ideal model for EVLP due to less organ quality variability, eas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1862f4ec6c7f76661f3684dc8897a94d
https://doi.org/10.1142/s2339547820500028

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Cell release during perfusion reflects cold ischemic injury in rat livers

Autor: Shannon L. Stott, Thomas M. van Gulik, Reinier J. de Vries, Heidi Yeh, Stephanie E.J. Cronin, Ehab O A Hafiz, Alona Muzikansky, Beatriz Marques, Shannon N. Tessier, Mehmet Toner, James F. Markmann, Casie A. Pendexter, Korkut Uygun

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific reports, 10(1):1102. Nature Publishing Group

The global shortage of donor organs has made it crucial to deeply understand and better predict donor liver viability. However, biomarkers that effectively assess viability of marginal grafts for organ transplantation are currently lacking. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2724989a03a992476594ae60814fb337
http://link.springer.com/article/10.1038/s41598-020-57589-4

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Supercooling extends preservation time of human livers

Autor: Thomas M. van Gulik, Korkut Uygun, Mehmet Toner, Sonal Nagpal, Martin L. Yarmush, Heidi Yeh, James F. Markmann, Sinan Ozer, Peony D. Banik, Stephanie E.J. Cronin, Ehab O A Hafiz, Shannon N. Tessier, Reinier J. de Vries

Publikováno v: Nature biotechnology, 37(10), 1131-1136. Nature Publishing Group

The inability to preserve vascular organs beyond several hours contributes to the scarcity of organs for transplantation1,2. Standard hypothermic preservation at +4 °C (refs. 1,3) limits liver preservation to less than 12 h. Our group previously sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ae194e5d749b2af6bd5b50710ec51c
https://doi.org/10.1038/s41587-019-0223-y

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Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion

Autor: Thomas M. van Gulik, Siavash Raigani, Korkut Uygun, Peili Chen, Stephanie E.J. Cronin, Reinier J. de Vries, Padraic Romfh, Benjamin T. Wilks, Shannon N. Tessier, Rohil Jain, Casie A. Pendexter, Heidi Yeh

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0258833 (2021)
PLoS ONE, 16(10 October):e0258833. Public Library of Science
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE

Ischemia reperfusion injury (IRI) is a critical problem in liver transplantation that can lead to life-threatening complications and substantially limit the utilization of livers for transplantation. However, because there are no early diagnostics av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b50b0c2bf51281ac2179daf995d9469
https://doaj.org/article/0240f347847f42e788e242f973e8b22a

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Abstract 403: Leveraging the Zebrafish to Overcome Barriers in Heart Transplantation

Autor: Juan Manuel González-Rosa, Korkut Uygun, Casie A. Pendexter, Felix Ellett, Luciana Da Silveira Cavalcante, Shannon N. Tessier, Mehmet Toner, Beatriz Marques, Kaustav Gopinathan, Stephanie E.J. Cronin, Samantha To, David M. Langenau, Reinier J. de Vries

Publikováno v: Circulation Research. 127

Cardiac transplantation is the only curative therapy for patients with end-stage heart disease; however, there is a severe shortage of viable donor organs. Heart transplantation faces many interwoven challenges, including both biological factors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e094dcedc0edbad2d254616de43a0682
https://doi.org/10.1161/res.127.suppl_1.403

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Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion

Autor: Corey Eymard, Negin Karimian, James F. Markmann, Korkut Uygun, Paria Mahboub, Francis L. Delmonico, Casie A. Pendexter, Heidi Yeh, Sonal Nagpal, Fermin Fontan, Mohamed M. Aburawi, Sinan Ozer, Peony D. Banik, Stephanie E.J. Cronin

Publikováno v: Am J Transplant

Normothermic Machine Perfusion presents a novel platform for per-transplant assessment and reconditioning of kidney grafts. Maintaining the metabolic activity of a preserved graft at physiologic levels requires an adequate oxygen supply, typically de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2229c3b12584eaba9d842a93d26d5cd6
https://pubmed.ncbi.nlm.nih.gov/30938927

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