Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Stephanie E. Rivera"'
1
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1signalling
Autor: Aaron Zirk, G. R. Scott Budinger, David W. Kamp, Minghua Wu, Manu Jain, Jacob I. Sznajder, Daniela Urich, Moisés Selman, Asish K. Ghosh, Annie Pardo, Leonard H.T. Go, Sergio E. Chiarella, John Varga, Stephanie E. Rivera, Navdeep S. Chandel, Anna P. Lam, Gökhan M. Mutlu
Publikováno v: Thorax. 67:139-146
Background The development of organ fibrosis after injury requires activation of transforming growth factor β 1 which regulates the transcription of profibrotic genes. The systemic administration of a proteasomal inhibitor has been reported to preve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130335ffadeea5aa80110e9f342bf250
https://doi.org/10.1136/thoraxjnl-2011-200717
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2
Leptin Promotes Fibroproliferative Acute Respiratory Distress Syndrome by Inhibiting Peroxisome Proliferator–activated Receptor-γ
Autor: G. R. Scott Budinger, Asish K. Ghosh, Manu Jain, Navdeep S. Chandel, Kathryn A. Radigan, Stephanie E. Rivera, John Varga, Katie Marks, Gökhan M. Mutlu, Helen K. Donnelly, Saul Soberanes, Angel Gonzalez, Daniela Urich, Sergio E. Chiarella, Amy C. Y. Lo
Publikováno v: American Journal of Respiratory and Critical Care Medicine. 183:1490-1498
Diabetic patients have a lower incidence of acute respiratory distress syndrome (ARDS), and those who develop ARDS are less likely to die. The mechanisms that underlie this protection are unknown.To determine whether leptin resistance, a feature of d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3392942e7436cc496a9dec902dd3ad6
https://doi.org/10.1164/rccm.201009-1409oc
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3
Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling
Autor: Elena A. Monclus, Aaron Zirk, Carol Feghali-Bostwick, Gökhan M. Mutlu, Navdeep S. Chandel, Stephanie E. Rivera, G. R. Scott Budinger, James Eisenbart, Manu Jain, Lauren Synenki
TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-β binds to cell-surface receptors, resulting in the phosphory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15a20d23427a534ab8ba16a7c3d30c3
https://europepmc.org/articles/PMC3543026/
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Plný text Recenzováno Digitální knihovna AV ČR
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