Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stephanie E. North"'
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acad2e5bc90e5150a426ee4a47d0973f
https://doi.org/10.1002/9781118949689.ch12
https://doi.org/10.1002/9781118949689.ch12
Publikováno v:
Journal of Chromatography B. 876:182-190
Definitive information on the metabolism of a drug candidate in humans is achieved through dosing radiolabelled drug as part of a clinical study, and is typically conducted post-proof of concept in Phase III of the clinical development plan. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e746e5f24ebb903dd8574c0c77d3a5
https://doi.org/10.1016/j.jchromb.2008.10.040
https://doi.org/10.1016/j.jchromb.2008.10.040
Autor:
Mark S. Duxon, Peter J. Atkinson, Tracey E. Shaw, David R. Thomas, Kevin M. Thewlis, Michael S. Hadley, Beverley Hammond, Geoffrey Stemp, Gary W. Price, Claire M. Scott, Vong Antonio Kuok Keong, Jeannette M. Watson, Steven Mark Bromidge, Christopher N. Johnson, Graham J. Riley, Derek N. Middlemiss, Harshad Kantilal Rami, Stephanie E. North, Laramie Mary Gaster, Kathryn R. Starr, Mervyn Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:737-741
Starting from a high throughput screening hit, a series of 3,4-dihydro-2H-benzoxazinones has been identified with both high affinity for the 5-HT(1A) receptor and potent 5-HT reuptake inhibitory activity. The 5-(2-methyl)quinolinyloxy derivative comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0251a65c1ec7fac2128405b3379b6c
https://doi.org/10.1016/j.bmcl.2004.11.030
https://doi.org/10.1016/j.bmcl.2004.11.030
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 41(8)
The article describes and discusses the evolution of strategies to characterize metabolites in support of safety studies over the last 40 years, as well as future trends. Approaches to derive qualitative and quantitative information on metabolites ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2229626dbdddd3d2337b1e32a857e01b
https://pubmed.ncbi.nlm.nih.gov/21446837
https://pubmed.ncbi.nlm.nih.gov/21446837
Autor:
Richard J. Smith, Ben Bardsley, Tony L. Beck, Stephanie E. North, Emma Lee-Smith, Martin Sandvoss, Peter J. Moore, Andrew J. Edwards
Publikováno v:
Magnetic resonance in chemistry : MRC. 43(9)
High-performance liquid chromatography-solid phase extraction-NMR spectroscopy (HPLC-SPE-NMR) has recently become commercially available and has been evaluated with regard to its applicability in a pharmaceutical environment. The addition of an autom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c9fff181dd116d17c5b2c4f29b5c30
https://pubmed.ncbi.nlm.nih.gov/16049946
https://pubmed.ncbi.nlm.nih.gov/16049946
Publikováno v:
Journal of chromatography. A. 1028(2)
In combining the high peak concentrations of capillary liquid chromatography (CapLC) with the high mass sensitivity of micro scale nuclear magnetic resonance (NMR) the hyphenation of CapLC to micro NMR offers a substantial gain in overall sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ca6a3bd2113f7a2f04c0ea4a8586c4
https://pubmed.ncbi.nlm.nih.gov/14989479
https://pubmed.ncbi.nlm.nih.gov/14989479