Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephanie E van Gijn"'
Autor:
Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated
Externí odkaz:
https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed
Autor:
Marcel A. T. M. van Vugt, Thijn R. Brummelkamp, Anne Margriet Heijink, Stephanie E van Gijn, Rudolf S N Fehrmann, Francien Talens, Lucas T. Jae
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group
Loss of BRCA2 affects genome stability and is deleterious for cellular survival. Using a genome-wide genetic screen in near-haploid KBM-7 cells, we show that tumor necrosis factor-alpha (TNFα) signaling is a determinant of cell survival upon BRCA2 i
Autor:
Boudewijn E. C. Plaat, Bert van der Vegt, Kirsten L. Moek, Marcel A. T. M. van Vugt, Saskia H Hanemaaijer, Stephanie E van Gijn, Jan L. N. Roodenburg, Ed Schuuring, Bernard F. A. M. van der Laan, Rudolf S N Fehrmann, Sjoukje F. Oosting
Publikováno v:
Oral Oncology, 80, 33-39. ELSEVIER SCIENCE BV
Background: For patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) palliative treatment options that improve overall survival are limited. The prognosis in this group remains poor and there is an unmet need for new th
Autor:
Floris Foijer, Elles Wierenga, Yannick P Kok, Rudolf S N Fehrmann, Diana C.J. Spierings, Nathalie van den Tempel, Anne Margriet Heijink, Stephanie E van Gijn, Marcel A. T. M. van Vugt
Publikováno v:
Oncogene
ONCOGENE, 38(6), 852-867. Nature Publishing Group
ONCOGENE, 38(6), 852-867. Nature Publishing Group
Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BR
Autor:
Rudolf S N Fehrmann, Elles Wierenga, Anne Margriet Heijink, Stephanie E van Gijn, Marcel A. T. M. van Vugt
Publikováno v:
Cancer Research. 77:1409-1409
Mutations in homologous recombination (HR) genes, including BRCA1 and BRCA2, compromise DNA repair and lead to genomic instability (GI). GI is lethal to normal cells but is a characteristic of many cancers. Apparently, these cancers are somehow re-wi