Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephanie E Crilly"'
Publikováno v:
eLife, Vol 10 (2021)
The prevailing model for the variety in drug responses is that different drugs stabilize distinct active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to different effectors. However, whether the same ligand generates d
Externí odkaz:
https://doaj.org/article/66e06d8ec03a497d93f59280819150ea
Autor:
Loyda M. Morales Rodríguez, Stephanie E. Crilly, Jacob B. Rowe, Daniel G. Isom, Manojkumar A. Puthenveedu
Publikováno v:
bioRxiv
The canonical view of G protein-coupled receptor (GPCR) function is that receptor trafficking is tightly coupled to signaling. GPCRs remain on the plasma membrane (PM) at the cell surface until they are activated, after which they are desensitized an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0266d5d4898efb79a472f34447c347
https://europepmc.org/articles/PMC10055196/
https://europepmc.org/articles/PMC10055196/
Publikováno v:
J Membr Biol
G protein-coupled receptors (GPCRs) are integral membrane proteins that transduce a wide array of inputs including light, ions, hormones, and neurotransmitters into intracellular signaling responses which underlie complex processes ranging from visio
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
The prevailing model for the variety in drug responses is that they stabilize distinct active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to different effectors. However, whether the same ligand can produce different
Publikováno v:
Molecular Biology of the Cell
The delta opioid receptor (DOR), a physiologically relevant prototype for G protein–coupled receptors, is retained in intracellular compartments in neuronal cells. This retention is mediated by a nerve growth factor (NGF)-regulated checkpoint that
Autor:
Junmin Peng, Graham Ladds, Manojkumar A. Puthenveedu, Amanda E. Mackenzie, Christian Munk, Matthew Harris, Xusheng Wang, Graeme Milligan, Tezz Quon, Stephanie E Crilly, M. Madan Babu, David E. Gloriam, Andrew B. Tobin, Maria Marti-Solano, Duccio Malinverni, Abigail Pearce
Publikováno v:
Nature
G protein-coupled receptors (GPCRs) are transmembrane proteins that modulate physiology across diverse tissues in response to extracellular signals. GPCR signalling can differ due to variation in the sequence (e.g. polymorphisms) or in the expression
Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566398c0771fdbf06d03b0199eda83b5
https://europepmc.org/articles/PMC6462236/
https://europepmc.org/articles/PMC6462236/
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
David W. Speicher, Megan D. Radyk, Sandra L. Harper, Floyd J. Mattie, Stephanie E Crilly, Mansi R. Khanna, Graham H. Thomas, Katelyn J. Bakerink, Kristen C. Browder
Publikováno v:
The Journal of biological chemistry. 290(2)
The dominant paradigm for spectrin function is that (αβ)2-spectrin tetramers or higher order oligomers form membrane-associated two-dimensional networks in association with F-actin to reinforce the plasma membrane. Tetramerization is an essential e