Výsledky vyhledávání - "Stephanie E B, McArdle"

Akademický článek

Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments

Autor: Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Although the discovery and characterization of multiple tumor antigens have sparked the development of many antigen/derived cancer vaccines, many are poorly immunogenic and thus, lack clinical efficacy. Adjuvants are therefore incorporated into vacci

Externí odkaz: https://doaj.org/article/ab751ec711c943a4a2c36f31730dcf02

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Akademický článek

Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment

Autor: Joshua R. D. Pearson, Stefania Cuzzubbo, Simon McArthur, Lindy G. Durrant, Jason Adhikaree, Chris J. Tinsley, A. Graham Pockley, Stephanie E. B. McArdle

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or more after diagnosis. Despite aggressive multimodal therapy, consis

Externí odkaz: https://doaj.org/article/6a7407adfcab4c87aab9894173687565

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Akademický článek

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer

Autor: Gemma A. Foulds, Jayakumar Vadakekolathu, Tarek M. A. Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M. Moseley, Stephen Y. T. Chan, A. Graham Pockley, Sergio Rutella, Stephanie E. B. McArdle

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Background: Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could be influenced or predicted by immune events that manifest locally, but can be

Externí odkaz: https://doaj.org/article/ff8ec7bc8e834c0b9816a47eb4669bf7

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Akademický článek

Immune Landscape of Breast Cancers

Autor: Divya Nagarajan, Stephanie E. B. McArdle

Publikováno v: Biomedicines, Vol 6, Iss 1, p 20 (2018)

Breast cancer is a very heterogeneous disease, both at a molecular and a histological level. Five intrinsic subtypes were initially identified—Luminal-A, Luminal-B, HER2+, Triple negative/basal like (TNBC) and normal like—subsequently expanded to

Externí odkaz: https://doaj.org/article/d1266d2238654928814d7f33c893073f

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Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

Autor: Georgina Cosma, Simon P. Hood, Masood A. Khan, Catherine Johnson, Stephen Reeder, Stephanie E. B. McArdle, Gemma A. Foulds, A. Graham Pockley

Publikováno v: eLife, Vol 9 (2020)
eLife

We demonstrate that prostate cancer can be identified by flow cytometric profiling of blood immune cell subsets. Herein, we profiled natural killer (NK) cell subsets in the blood of 72 asymptomatic men with Prostate-Specific Antigen (PSA) levels < 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c546709c8db82419d135185b14745f36
https://doi.org/10.7554/elife.50936

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Abstract P1-08-06: Not presented

Autor: Alan Graham Pockley, D Christensen, Stephanie E. B. McArdle, Lindy G. Durrant, D Nagarajan

Publikováno v: Cancer Research. 78:P1-08

This abstract was not presented at the symposium.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76959ccc2dae6e4a5772440237ddd37e
https://doi.org/10.1158/1538-7445.sabcs17-p1-08-06

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Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α

Autor: Ana Cristina Gonçalves, Raquel Alves, Jayakumar Vadakekolathu, Stephanie E. B. McArdle, Sergio Rutella, Amélia Pereira, Paulo Freitas-Tavares, Antonio Almeida, Ana Bela Sarmento-Ribeiro

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Translational Medicine

Background Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddaeb03c6dabcaa3737185a14df3841
https://hdl.handle.net/10400.14/32300

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