Výsledky vyhledávání - "Stephanie E, Zimmer"

Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease

Autor: Akiharu Kubo, Masashi Akiyama, Daniel E. Conway, Takuya Takeichi, A. Kowalczyk, Stephanie E. Zimmer, Yasushi Suga

Publikováno v: J Invest Dermatol

Dominant and recessive mutations in the desmosomal cadherin, desmoglein (DSG) 1, cause the skin diseases palmoplantar keratoderma (PPK) and severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome, respectively. In this study, we c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e140de76fdbd1604d291af5ccf173496
https://pubmed.ncbi.nlm.nih.gov/34799122

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The desmosome as a model for lipid raft driven membrane domain organization

Autor: Stephanie E. Zimmer, Andrew P. Kowalczyk

Publikováno v: Biochim Biophys Acta Biomembr

Desmosomes are cadherin-based adhesion structures that mechanically couple the intermediate filament cytoskeleton of adjacent cells to confer mechanical stress resistance to tissues. We have recently described desmosomes as mesoscale lipid raft membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a76744b6bdad8cbcad33364144492c
https://pubmed.ncbi.nlm.nih.gov/32376221

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The desmosome is a mesoscale lipid raft-like membrane domain

Autor: Akiharu Kubo, James K. Wahl, Andrew P. Kowalczyk, Alexa L. Mattheyses, Sara N. Stahley, Masayuki Amagai, Nicole L. Strong, Anna Seybold, Ilya Levental, Akemi Ishida-Yamamoto, Yoichi Matsubara, Amber L Caldara, Joshua D. Lewis, Achilleas S. Frangakis, Takashi Sasaki, Kenichiro Hata, Kazuhiko Nakabayashi, Stephanie E. Zimmer

Publikováno v: Molecular Biology of the Cell

Desmogleins (Dsgs) are cadherin family adhesion molecules essential for epidermal integrity. Previous studies have shown that desmogleins associate with lipid rafts, but the significance of this association was not clear. Here, we report that the des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3615a87f30774c32bf48c40ba3ecae
https://pubmed.ncbi.nlm.nih.gov/30943110

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The Desmosome is a Mesoscale Lipid Raft-Like Membrane Domain

Autor: Alexa L. Mattheyses, Nicole L. Strong, Takashi Sasaki, Masayuki Amagai, Akemi Ishida-Yamamoto, Sara N. Stahley, Yoichi Matsubara, Kazuhiko Nakabayashi, Andrew P. Kowalczyk, Anna Seybold, Amber L Caldara, Joshua D. Lewis, Achilleas S. Frangakis, Stephanie E. Zimmer, Kenichiro Hata, Ilya Levental, James K. Wahl, Akiharu Kubo

SummaryDesmogleins are cadherin family adhesion molecules essential for epidermal integrity. Previous studies have shown that desmogleins associate with lipid rafts, but the significance of this association was not clear. Here, we report that the des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859cbfc7888f85fc85833d8eeff44550
https://doi.org/10.1101/401455

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Single-Cell Analysis Suggests that Ongoing Affinity Maturation Drives the Emergence of Pemphigus Vulgaris Autoimmune Disease

Autor: Maurizio Affer, Carson Norwood, Aaron Scanlan, Alexandra Llovet, Bridget Bradley, Grace Mantus, Andrew P. Kowalczyk, Michael Hertl, Robert C. Kauffman, Ron J. Feldman, Stephanie E. Zimmer, Nina A. Ran, Zach Menne, Alice Cho, Amber L Caldara, Aimee S. Payne, Jens Wrammert, Thomas Schmidt

Publikováno v: Cell reports

SUMMARY Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering sores on skin and mucosal membranes, caused by autoantibodies primarily targeting the cellular adhesion protein, desmoglein-3 (Dsg3). To better understand how Dsg3-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0738b94d3e77393f27eaad05ea764a02
https://doi.org/10.1016/j.celrep.2019.06.066

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Splice form-dependent regulation of axonal arbor complexity by FMRP

Autor: Stephanie E, Zimmer, Steven G, Doll, A Denise R, Garcia, Michael R, Akins

Publikováno v: Developmental neurobiology. 77(6)

The autism-related protein Fragile X mental retardation protein (FMRP) is an RNA binding protein that plays important roles during both nervous system development and experience dependent plasticity. Alternative splicing of the Fmr1 locus gives rise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72545e8d843033f842c641448ff438fd
https://pubmed.ncbi.nlm.nih.gov/27643955

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