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Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints
Autor:
Paul Butler, Susan M.G. Goody, Annie Otto-Bruc, Jamie K. DaSilva, Rhys M. Jones, Andy N. Mead, Asser Bassyouni, Stephen Jenkinson, Stephanie Duquennoy
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 104:106899
Introduction Building an understanding of in vivo efficacy based on the evaluation of in vitro affinity or potency is critical in expediting early decision making in drug discovery and can significantly reduce the need for animal studies. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430ed02441c6880c6896f2d5be537453
https://doi.org/10.1016/j.vascn.2020.106899
https://doi.org/10.1016/j.vascn.2020.106899
