Výsledky vyhledávání - "Stephanie D. Burr"

Akademický článek

PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein

Autor: Scott M. Johnson, Hanmei Bao, Cailin E. McMahon, Yongbin Chen, Stephanie D. Burr, Aaron M. Anderson, Katja Madeyski-Bengtson, Daniel Lindén, Xianlin Han, Jun Liu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The I148M variant of PNPLA3 is closely associated with hepatic steatosis. Recent evidence indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated lipolysis, leaving the role of wild-type PNPLA3 undefined. Despite sh

Externí odkaz: https://doaj.org/article/446ac4633cd64e55aab1453331558861

Zobrazit plný text záznamu

Akademický článek

Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor

Autor: Stephanie D. Burr, Yongbin Chen, Christopher P. Hartley, Xianda Zhao, Jun Liu

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Dietary saturate fatty acids (SFAs) have been consistently linked to atherosclerosis and obesity, both of which are characterized by chronic inflammation and impaired lipid metabolism. In comparison, the effects of linoleic acid (LA), the pr

Externí odkaz: https://doaj.org/article/44b8a6c2dc654cfdb7f44052e8077c87

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress

Autor: Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 9, p 4480 (2022)

Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor f

Externí odkaz: https://doaj.org/article/0c426b95b7c1458ab77815edb5053bfa

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The Impact of Diabetic Conditions and AGE/RAGE Signaling on Cardiac Fibroblast Migration

Autor: Stephanie D. Burr, Mallory B. Harmon, James A. Stewart Jr.

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle (LV), which is thought to occur, in part, by increased AGE/RAGE signaling inducing fibroblast differentiation. Advanced glycated

Externí odkaz: https://doaj.org/article/0339271fd0ff4bfdb2c30a551a90fa89

Zobrazit plný text záznamu

Akademický článek

A novel gene’s role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior–posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos

Autor: Anita Khadka, Marina Martínez-Bartolomé, Stephanie D. Burr, Ryan C. Range

Publikováno v: EvoDevo, Vol 9, Iss 1, Pp 1-15 (2018)

Abstract The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and vertebrates) is progressively restricted along the anterior–posterior axis to a domain around the anterior pole.

Externí odkaz: https://doaj.org/article/044fb16565e54de3b789587b62c65e3c

Zobrazit plný text záznamu

Akademický článek

Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade

Autor: Stephanie D. Burr, James A. Stewart

Publikováno v: Cells, Vol 10, Iss 6, p 1286 (2021)

Cardiovascular disease is a common diabetic complication that can arise when cardiac fibroblasts transition into myofibroblasts. Myofibroblast transition can be induced by advanced glycated end products (AGEs) present in the extracellular matrix (ECM

Externí odkaz: https://doaj.org/article/ef5cfcde3280401b851d928d9f61c622

Zobrazit plný text záznamu

Akademický článek

Rap1a Overlaps the AGE/RAGE Signaling Cascade to Alter Expression of α-SMA, p-NF-κB, and p-PKC-ζ in Cardiac Fibroblasts Isolated from Type 2 Diabetic Mice

Autor: Stephanie D. Burr, James A. Stewart

Publikováno v: Cells, Vol 10, Iss 3, p 557 (2021)

Cardiovascular disease, specifically heart failure, is a common complication for individuals with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by “active” cardiac fibroblasts (i.e.,

Externí odkaz: https://doaj.org/article/675d1bba55e14455add46d6fdfa75f37

Zobrazit plný text záznamu

Plný text ve formátu HTML

Rap1a Overlaps the AGE/RAGE Signaling Cascade to Alter Expression of α-SMA, p-NF-κB, and p-PKC-ζ in Cardiac Fibroblasts Isolated from Type 2 Diabetic Mice

Autor: James A. Stewart, Stephanie D. Burr

Publikováno v: Cells, Vol 10, Iss 557, p 557 (2021)
Cells
Volume 10
Issue 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e784b36cdbe91b4cac348990849282
https://www.mdpi.com/2073-4409/10/3/557

Zobrazit plný text záznamu

A Cost Effective and Adaptable Scratch Migration Assay

Autor: Stephanie D. Burr, James A. Stewart

Publikováno v: Journal of visualized experiments : JoVE. (160)

Cell migration is a key component in both physiological and pathological events. Normal cell migration is required for essential functions such as development and mounting an immune response. When a defect or alteration occurs with the cell migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef12b5be0c5ffbdd951092f0a412911
https://pubmed.ncbi.nlm.nih.gov/32716370

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání