Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

Autor: Michela Mazzon, Ana Maria Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Katy Skelton, Laura Farleigh, Joachim J. Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner, Mark Marsh

Publikováno v: Viruses, Vol 11, Iss 2, p 176 (2019)

Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made a

Externí odkaz: https://doaj.org/article/a8a22de4d5bc47b2aace70eda318bf5b

A membrane topology model for human interferon inducible transmembrane protein 1.

Autor: Stuart Weston, Stephanie Czieso, Ian J White, Sarah E Smith, Paul Kellam, Mark Marsh

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104341 (2014)

InterFeron Inducible TransMembrane proteins 1-3 (IFITM1, IFITM2 and IFITM3) are a family of proteins capable of inhibiting the cellular entry of numerous human and animal viruses. IFITM1-3 are unique amongst the currently described viral restriction

Externí odkaz: https://doaj.org/article/4d5de7daf58b49f2a0e598791beb500a

Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection

Autor: Eleni Amaniti, Nikolay Nikolov, Stephanie Czieso, Cary D. Austin, Abdul Sesay, Sean Flanagan, Dennis Wilson, Christine Clarke, Jessica Mills, Riccardo Guidi, Yi Cao, Mark S. Wilson, Probir Chakravaty, Alison Huynh, Lewis J. Entwistle, Shannon Hambro, Helena Aegerter, Laurie Leong, Victor Nunez, Angela Martzall

Publikováno v: MUCOSAL IMMUNOLOGY
Mucosal Immunology

Acute exacerbations (AE) of asthma, remain one of the biggest concerns for patients living with asthma. As such, identifying the causes, the molecular mechanisms involved and new therapeutic interventions to prevent AE is a high priority. Immunity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e5f049561e525f5006eb9aa9041a49
https://doi.org/10.1038/s41385-021-00401-x

Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells

Autor: Eva Gückel, Mark S. Wilson, Stephanie Czieso, Isobel S. Okoye, Andrew S. MacDonald, Victoria S. Pelly, Yanda Li, Yashaswini Kannan, Stephanie M. Coomes, Nikolay Nikolov, Lauren M. Webb, Srividya Sriskantharajah, Steven C. Ley

Publikováno v: Kannan, Y, Li, Y, Coomes, S M, Okoye, I S, Pelly, V, Sriskantharajah, S, Gückel, E, Webb, L, Czieso, S, Nikolov, N, MacDonald, A, Ley, S C & Wilson, M S 2017, ' Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells ', Journal of Allergy and Clinical Immunology, vol. 139, no. 2 . https://doi.org/10.1016/j.jaci.2016.05.031
The Journal of Allergy and Clinical Immunology

BACKGROUND: The molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. Tumor progression locus 2 (TPL-2) (COT, MAP3K8) kinase activates the MEK1/2-extracellular-signal regulated kinase 1/2 MAP kinase signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bb032d36ffee65605f85a8574718ae
https://www.research.manchester.ac.uk/portal/en/publications/tumor-progression-locus-2-reduces-severe-allergic-airway-inflammation-by-inhibiting-ccl24-production-in-dendritic-cells(0a09f5db-2bf3-4f69-859a-08a968ec9c87).html

Alphavirus Restriction by IFITM Proteins

Autor: Stuart, Weston, Stephanie, Czieso, Ian J, White, Sarah E, Smith, Rachael S, Wash, Carmen, Diaz-Soria, Paul, Kellam, Mark, Marsh

Publikováno v: Traffic (Copenhagen, Denmark)

Interferon inducible transmembrane proteins (IFITMs) are broad‐spectrum antiviral factors. In cell culture the entry of many enveloped viruses, including orthomyxo‐, flavi‐, and filoviruses, is inhibited by IFITMs, though the mechanism(s) invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e66bfe39432592d9c43b16e4b94931f
https://pubmed.ncbi.nlm.nih.gov/27219333