Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephanie Chidester"'
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Extracellular vesicles (EVs) released by cells throughout the body have been implicated in diabetes pathogenesis. Understanding the role of EVs in regulation of β-cell function and viability may provide insights into diabetes etiology and may lead t
Externí odkaz:
https://doaj.org/article/1ddae2a2b34d45d09f3fe1e015cd1631
Autor:
Jessica Maddox, Arvind Shakya, Samuel South, Dawne Shelton, Jared N Andersen, Stephanie Chidester, Jinsuk Kang, Keith M Gligorich, David A Jones, Gerald J Spangrude, Bryan E Welm, Dean Tantin
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003048 (2012)
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription st
Externí odkaz:
https://doaj.org/article/0919bdc7bcae48b0ba2c398df15a22d4
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Frontiers in Endocrinology
Frontiers in Endocrinology
Extracellular vesicles (EVs) released by cells throughout the body have been implicated in diabetes pathogenesis. Understanding the role of EVs in regulation of β-cell function and viability may provide insights into diabetes etiology and may lead t
Autor:
Kunal Rai, Bradley R. Cairns, David A. Jones, Adam R. Karpf, Itrat F. Jafri, Smitha R. James, Stephanie Chidester
Publikováno v:
The Journal of Biological Chemistry
Although DNA methylation is critical for proper embryonic and tissue-specific development, how different DNA methyltransferases affect tissue-specific development and their targets remains unknown. We address this issue in zebrafish through antisense
Autor:
Kunal Rai, Smitha R. James, David A. Jones, Bradley R. Cairns, Adam R. Karpf, Elizabeth J. Manos, Stephanie Chidester, Lincoln Nadauld
Publikováno v:
Molecular and Cellular Biology. 26:7077-7085
DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address thi
Autor:
David A. Jones, Annie L. Eisinger, Dawne N. Shelton, Chris M. Ireland, Anokha S. Ratnayake, Stephanie Chidester, Imelda T. Sandoval
Publikováno v:
Cancer Research. 66:7571-7577
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to underlie the initiation of many colorectal carcinomas. Loss of APC function results in accumulation of β-catenin and activation of β-catenin/TCF–dependent transcripti
Autor:
Stephen M. Prescott, Peter Peterson, Lincoln Nadauld, Reid A. Phelps, Diana M. Stafforini, Dawne N. Shelton, Stephanie Chidester, David A. Jones, Annie L. Eisinger
Publikováno v:
Journal of Biological Chemistry. 281:20474-20482
Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest stages of colorectal carcinogenesis. Cyclooxygenase-2 (COX-2) is elevated in human colorec
Autor:
Jared N. Andersen, David A. Jones, Dean Tantin, Jessica Maddox, Jinsuk Kang, Bryan E. Welm, Keith M. Gligorich, Dawne N. Shelton, Samuel South, Gerald J. Spangrude, Stephanie Chidester, Arvind Shakya
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003048 (2012)
PLoS Genetics
PLoS Genetics
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription st
Autor:
Rachel K. Toth, Brad Sklow, Kenneth F. Grossmann, Kunal Rai, Matthew Voas, Sharmistha Sarkar, Fanuel T. Hagos, Bradley R. Cairns, Lincoln Nadauld, Randall W. Burt, Timothy M. Bahr, W. Evan Johnson, Yumei Li, Talmage J. Broadbent, David A. Jones, Somaye Dehghanizadeh, Stephanie Chidester
SummaryAlthough genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afdfb18114e47a0f718519dbe634e06
https://europepmc.org/articles/PMC2943938/
https://europepmc.org/articles/PMC2943938/
Autor:
Smitha R. James, David A. Jones, Chad V. Zavala, Kunal Rai, Elizabeth J. Manos, Stephanie Chidester, Bradley R. Cairns, Adam R. Karpf
The roles of DNA methyltransferase-2 (DNMT2) enzymes are controversial; whether DNMT2 functions primarily as a nuclear DNA methyltransferase or as a cytoplasmic tRNA methyltransferase, and whether DNMT2 activity impacts development, as dnmt2 mutant m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d62a120c11aa88c02d28b2f4b750fad
https://europepmc.org/articles/PMC1785123/
https://europepmc.org/articles/PMC1785123/