Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy

Autor: Joana Domingos, Delphine Labolle, Teresa Gidaro, Francesco Muntoni, Florence Porte Thomé, Camilla Johansson, Stefano C. Previtali, Jordi Díaz-Manera, Pietro Spitali, Julian Gray, Mirko Signorelli, Stephanie Carnesecchi, Jacqueline Pitchforth, Alberto Zambon, Cristina Al-Khalili Szigyarto, Pascale Roux-Lombard

Publikováno v: Pharmacological Research
Pharmacological Research, 159. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Pharmacological Research, Vol. 159 (2020) P. 104999
PHARMACOLOGICAL RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Pharmacological Research, Elsevier, 2020, 159, pp.104999. ⟨10.1016/j.phrs.2020.104999⟩
Pharmacological Research, 2020, 159, pp.104999. ⟨10.1016/j.phrs.2020.104999⟩

Graphical abstract
Rimeporide, a first-in-class sodium/proton exchanger Type 1 inhibitor (NHE-1 inhibitor) is repositioned by EspeRare for patients with Duchenne Muscular Dystrophy (DMD). Historically, NHE-1 inhibitors were developed for cardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b8729ff350898f440539f0a8d39358
http://europepmc.org/articles/PMC7482441

Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

Autor: Yves Donati, Constance Barazzone-Argiroffo, Filippo Zanetti, Maud Frieden, Stephanie Carnesecchi, Marta Giacomello

Publikováno v: Free radical biology & medicine
Free Radical Biology and Medicine, Vol. 76 (2014) pp. 173-84

Nicotine contributes to the onset and progression of several pulmonary diseases. Among the various pathophysiological mechanisms triggered by nicotine, oxidative stress and cell death are reported in several cell types. We found that chronic exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba62bd92d1fbae9fdf0d41767f8e3ec

NOX enzymes: potential target for the treatment of acute lung injury

Autor: Stephanie Carnesecchi, Jean-Claude Pache, Constance Barazzone-Argiroffo

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Vol. 69, No 14 (2012) pp. 2373-85
Cellular and molecular life sciences : CMLS

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), is characterized by acute inflammation, disruption of the alveolar-capillary barrier, and in the organizing stage by alveolar pneumocytes hyperplasia and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acb654d04d3642d620bf41c1a925c34
https://doi.org/10.1007/s00018-012-1013-6

Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation

Autor: C. Ronald Kahn, Masa Katic, Sanae Ben Mkaddem, Klaus Steger, Yu-Hua Tseng, Wei Wang, Stephanie Carnesecchi, Ildiko Szanto, Christoph A. Meier, Sarah Mouche, Eric Ogier-Denis, Patrick Muzzin, Michelangelo Foti

Publikováno v: Biochimica et Biophysica Acta, Vol. 1773, No 7 (2007) pp. 1015-27

Adipocyte differentiation is a complex process regulated among other factors by insulin and the production of reactive oxygen species (ROS). NOX4 is a ROS generating NADPH oxidase enzyme mediating insulin′s action in 3T3L1 adipocytes. In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ca868b282e7476fbfc2becba61ef39
https://doi.org/10.1016/j.bbamcr.2007.03.003

NOX3-TARGETED THERAPIES FOR INNER EAR PATHOLOGIES

Autor: Stephanie Carnesecchi, Karl-Heinz Krause, Francis Rousset, Pascal Senn

Publikováno v: Current pharmaceutical design. 21(41)

Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. In many of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism. While the sources of ROS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e16737426f0b79bf0b7da81a8181ac
https://pubmed.ncbi.nlm.nih.gov/26510434