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pro vyhledávání: '"Stephanie Baello"'
Autor:
Gideon Koren, Lauren E. Kelly, Stephanie Baello, Jessica Lam, David Chitayat, Stephen G. Matthews, Majid Iqbal, Patrick Shannon
Publikováno v:
Pediatric Research. 78:417-421
Neonates have been shown to have a heightened sensitivity to the central depressive effects of opioids compared to older infants and adults. The limited development of P-glycoprotein (P-gp) may limit the ability of the neonate to efflux morphine from
Publikováno v:
Physiological Reports
Brain endothelial cells (BECs) form a major component of the blood–brain barrier (BBB). In late gestation, these cells express high levels of the multidrug transporter p‐glycoprotein (P‐gp; encoded by Abcb1), which prevents the passage of an ar
Autor:
Samantha Kearney, Stephanie Baello, Stephen G. Matthews, Shikah Kuthiala, Majid Iqbal, William Gibb, Enrrico Bloise
Publikováno v:
Growth factors (Chur, Switzerland). 34(1-2)
Transforming growth factor-β1 (TGF-β1) increases P-glycoprotein (P-gp; encoded by Abcb1) activity in fetal brain endothelial cells (BECs). P-gp is important for fetal brain protection against xenobiotics including synthetic glucocorticoids (sGC). W
Autor:
Stephanie Baello, Stephen G. Matthews, Melanie C. Audette, William Gibb, Majid Iqbal, Mohsen Javam
Publikováno v:
Journal of Neuroendocrinology. 28
P-glycoprotein (P-gp) encoded by Abcb1 provides protection to the developing brain from xenobiotics. P-gp in brain endothelial cells (BECs) derived from the developing brain microvasculature is up-regulated by glucocorticoids and inhibited by pro-inf
Autor:
Stephen G. Matthews, Stephanie Baello, William Gibb, Majid Iqbal, Enrrico Bloise, Mohsen Javam
Publikováno v:
Endocrinology. 155(2)
P-glycoprotein (P-gp), an efflux transporter encoded by the abcb1 gene, protects the developing fetal brain. Levels of P-gp in endothelial cells of the blood-brain barrier (BBB) increase dramatically during the period of peak brain growth. This is co