Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephanie Alden"'
Autor:
Mark Awad, Giuseppe Lamberti, Lynette Sholl, Joao Victor Alessi, Stephanie Alden, Victor Vaz, Adriana Barrichello
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/8df1ae61f90146d7858e2011123c9746
Autor:
David R. Calabrese, Xiang Chen, Elena C. Leon, Snehal M. Gaikwad, Zaw Phyo, William M. Hewitt, Stephanie Alden, Thomas A. Hilimire, Fahu He, Aleksandra M. Michalowski, John K. Simmons, Lindsey B. Saunders, Shuling Zhang, Daniel Connors, Kylie J. Walters, Beverly A. Mock, John S. Schneekloth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 stru
Externí odkaz:
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80
Autor:
Beverly A. Mock, Kylie J. Walters, John K. Simmons, Shuling Zhang, Snehal M. Gaikwad, John S. Schneekloth, Elena C. Leon, Fahu He, David R. Calabrese, Daniel Connors, William M. Hewitt, Stephanie Alden, Aleksandra M. Michalowski, Thomas A. Hilimire, Zaw Phyo, Lindsey B. Saunders, Xiang Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce37ca6ecd2f80c8876cefec6c391f43
http://link.springer.com/article/10.1038/s41467-018-06315-w
http://link.springer.com/article/10.1038/s41467-018-06315-w
Autor:
Marc C. Nicklaus, Stephanie Alden, William M. Hewitt, John S. Schneekloth, Megan L. Peach, Sara N. Journey
Publikováno v:
MedChemComm. 9:2000-2007
Non-B DNA structures represent intriguing and challenging targets for small molecules. For example, the promoter of the HRAS oncogene contains multiple G-quadruplex and i-motif structures, atypical globular folds that serve as molecular switches for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad7b6fb160ffdc8dec33e97bef72c00
https://doi.org/10.1039/c8md00311d
https://doi.org/10.1039/c8md00311d
Autor:
David R. Calabrese, Katherine Zlotkowski, William M. Hewitt, John S. Schneekloth, Lu Chen, Colleen M. Connelly, Robert Wilson, Snehal M. Gaikwad, Craig J. Thomas, Beverly A. Mock, Rajarshi Guha, Stephanie Alden
Publikováno v:
Nucleic Acids Research
Approaches to characterize the nucleic acid-binding properties of drugs and druglike small molecules are crucial to understanding the behavior of these compounds in cellular systems. Here, we use a Small Molecule Microarray (SMM) profiling approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30247060d1d77d0d222b899178811e2
https://pubmed.ncbi.nlm.nih.gov/29481610
https://pubmed.ncbi.nlm.nih.gov/29481610