Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Stephanie A. Shumar"'
1
Akademický článek
Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver
Autor: Stephanie A. Shumar, Evan W. Kerr, Paolo Fagone, Aniello M. Infante, Roberta Leonardi
Publikováno v: Journal of Lipid Research, Vol 60, Iss 5, Pp 1005-1019 (2019)
Lipid metabolism requires CoA, an essential cofactor found in multiple subcellular compartments, including the peroxisomes. In the liver, CoA levels are dynamically adjusted between the fed and fasted states. Elevated CoA levels in the fasted state a
Externí odkaz: https://doaj.org/article/1c946483db0e4891875238a29f6f476d
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2
NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet
Autor: Schuyler D. Vickers, Stephanie A. Shumar, Dominique C. Saporito, Amina Kunovac, Quincy A. Hathaway, Breeanna Mintmier, Judy A. King, Rachel D. King, Vazhaikkurichi M. Rajendran, Aniello M. Infante, John M. Hollander, Roberta Leonardi
Publikováno v: The Journal of biological chemistry. 299(1)
Nudix hydrolase 7 (NUDT7) is an enzyme that hydrolyzes CoA species, is highly expressed in the liver, and resides in the peroxisomes. Peroxisomes are organelles where the preferential oxidation of dicarboxylic fatty acids occurs and where the hepatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528e6a48032181237073ef012b024559
https://pubmed.ncbi.nlm.nih.gov/36436558
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3
Akademický článek
Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.
Autor: Stephanie A Shumar, Paolo Fagone, Adolfo Alfonso-Pecchio, John T Gray, Jerold E Rehg, Suzanne Jackowski, Roberta Leonardi
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130013 (2015)
Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms
Externí odkaz: https://doaj.org/article/015a4f62aa274b6580709bbc9c4775a8
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4
Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver
Autor: Roberta Leonardi, Stephanie A. Shumar, Evan W. Kerr, Aniello M. Infante, Paolo Fagone
Publikováno v: Journal of Lipid Research, Vol 60, Iss 5, Pp 1005-1019 (2019)
J Lipid Res
Lipid metabolism requires CoA, an essential cofactor found in multiple subcellular compartments, including the peroxisomes. In the liver, CoA levels are dynamically adjusted between the fed and fasted states. Elevated CoA levels in the fasted state a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cade5ae8e7da5c04c8099ce68d9a8622
http://www.sciencedirect.com/science/article/pii/S0022227520322707
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9
Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice
Autor: Jerold E. Rehg, Adolfo Alfonso-Pecchio, Suzanne Jackowski, Paolo Fagone, John T. Gray, Roberta Leonardi, Stephanie A. Shumar
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130013 (2015)
PLoS ONE
Background Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (Pan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d720410d292706e935e3ab98a9696bf
http://europepmc.org/articles/PMC4460045?pdf=render
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