Zobrazeno 1 - 10 of 123 pro vyhledávání: '"Stephanie A. Myers"'
1
Akademický článek
In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency
Autor: Casie S. Kubota, Stephanie L. Myers, Toni T. Seppälä, Richard A. Burkhart, Peter J. Espenshade
Publikováno v: Molecular Metabolism, Vol 85, Iss , Pp 101964- (2024)
Objective: Cancer cells must maintain lipid supplies for their proliferation and do so by upregulating lipogenic gene programs. The sterol regulatory element-binding proteins (SREBPs) act as modulators of lipid homeostasis by acting as transcriptiona
Externí odkaz: https://doaj.org/article/d8ae974546924ca99dcf0bbe44ca3440
Zobrazit plný text záznamu
2
Abstract PR-009: Targeting the sterol regulatory element-binding protein pathway in pancreatic ductal adenocarcinoma
Autor: William Matsui, Wei Shao, Theodore Ewachiw, Stephanie L. Myers, Chine Liu, Toni Sepalla, Richard Burkhart, Zeshaan A. Rasheed, Meredith R. McGuire, Peter J. Espenshade
Publikováno v: Cancer Research. 81:PR-009
Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with limited diagnostic and therapeutic options. Due to its proliferative nature and thick, desmoplastic stroma, PDAC tumor cells are challenged with meeting a high demand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50c052484dc884c09de54fc01438b9b9
https://doi.org/10.1158/1538-7445.panca21-pr-009
Zobrazit plný text záznamu
3
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism
Autor: Alfica Sehgal, Debaditya Mukhopadhyay, Michael J. Wolfgang, Meredith R. McGuire, Kai Kammers, Rita T. Brookheart, Namandjé N. Bumpus, Eric P. Mosher, Peter J. Espenshade, Ebru S. Selen, Stephanie L. Myers
Publikováno v: The Journal of Biological Chemistry
Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein implicated in a wide range of cellular functions. We previously showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and supports their activity. Recen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c095f0e4cbf517a7bff30d6370b0944
https://doi.org/10.1016/j.jbc.2021.101316
Zobrazit plný text záznamu
7
High-throughput screening and hit validation of extracellular-related kinase 5 (ERK5) inhibitors
Autor: Timothy J. Blackburn, Roger J. Griffin, Tim Hammonds, Betty Cottyn, Ian R. Hardcastle, Sandrine Vidot, Lauren Molyneux, Bernard T. Golding, Celine Cano, William Clegg, Ruth H. Bawn, Louise Bisset, Hing Y. Leung, David R. Newell, Ai-Ching Wong, Stephanie M. Myers, Laurent Rigoreau, Ross W. Harrington
Publikováno v: ACS Combinatorial Science
ACS Combinatorial Science, ACS, 2016, 18, pp.444-455. ⟨10.1021/acscombsci.5b00155⟩
ACS Combinatorial Science (18), 444-455. (2016)
International audience; The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002ffb5033573e80911c966b43ada6d9
https://eprints.gla.ac.uk/139945/1/139945.pdf
Zobrazit plný text záznamu
8
Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy
Autor: Stephanie M, Myers, Ian, Collins
Publikováno v: Future medicinal chemistry
The kinesin class of microtubule-associated motor proteins present attractive anti-cancer targets owing to their roles in key functions in dividing cells. Two interpolar mitotic kinesins Eg5 and HSET have opposing motor functions in mitotic spindle a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aaf79e4d6b6c6e50f366dcf8bf674c0
https://pubmed.ncbi.nlm.nih.gov/26976726
Zobrazit plný text záznamu
9
SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load
Autor: Melissa A. McAlexander, Adam L. Moyer, Diego A. Espinoza, Erin L. Buchanan, Stephanie L. Myers, Kenneth W. Witwer
Publikováno v: Scientific Reports
Restriction of HIV-1 in myeloid-lineage cells is attributed in part to the nucleotidase activity of the SAM-domain and HD-domain containing protein (SAMHD1), which depletes free nucleotides, blocking reverse transcription. In the same cells, the Vpx
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab34126323a4d7ca0a69e5f329dd818
Zobrazit plný text záznamu
10
miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease
Autor: Erin L. Buchanan, Stephanie L. Myers, Kenneth W. Witwer, Melissa A. McAlexander
Publikováno v: Journal of Neuroinflammation. 12
Pilakka-Kanthikeel et al. recently reported higher levels of the retroviral restriction factor sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) in astrocytes than in microglia, suggesting that SAMHD1 levels might e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a954566ec39607d40dc349f7ef744806
https://doi.org/10.1186/s12974-015-0380-y
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje