Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Stephanie A. Booth"'
Publikováno v:
Prion, Vol 17, Iss 1, Pp 116-132 (2023)
ABSTRACTPrions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and animals. A current challenge to research is a lack of in vitro model systems that are
Externí odkaz:
https://doaj.org/article/f463c871e0d94d7480db5231782a1048
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death. The complexity of intercellular interactions in the brain is
Externí odkaz:
https://doaj.org/article/eb6491552a6b4206b5e093e1db4ba8c3
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Progressive dysfunction and loss of neurons ultimately culminates in the symptoms and eventual fatality of prion disease, yet the pathways and mechanisms that lead to neuronal degeneration remain elusive. Here, we used RNAseq to profile transcription
Externí odkaz:
https://doaj.org/article/b93e609511584e249384707caaf117e3
Autor:
Marta Sereno, János Haskó, Kinga Molnár, Sarah J. Medina, Zita Reisz, Rui Malhó, Mafalda Videira, László Tiszlavicz, Stephanie A. Booth, Imola Wilhelm, István A. Krizbai, Maria Alexandra Brito
Publikováno v:
Molecular Oncology, Vol 14, Iss 3, Pp 520-538 (2020)
Breast cancer brain metastases (BCBMs) have been underinvestigated despite their high incidence and poor outcome. MicroRNAs (miRNAs), and particularly circulating miRNAs, regulate multiple cellular functions, and their deregulation has been reported
Externí odkaz:
https://doaj.org/article/1d3836b6932b4e919bff7a905ddbbd77
Autor:
Jessy A. Slota, Sarah J. Medina, Megan Klassen, Damian Gorski, Christine M. Mesa, Catherine Robertson, Gordon Mitchell, Michael B. Coulthart, Sandra Pritzkow, Claudio Soto, Stephanie A. Booth
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Chronic wasting disease (CWD) is an emerging infectious prion disorder that is spreading rapidly in wild populations of cervids in North America. The risk of zoonotic transmission of CWD is as yet unclear but a high priority must be to minim
Externí odkaz:
https://doaj.org/article/af040d673aa34dee92178211e6bf509e
Autor:
Nikesh Tailor, Bryce M. Warner, Bryan D. Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P. Thomas, Yanlong Pei, Stephanie A. Booth, Carissa Embury-Hyatt, Sarah K. Wootton, Darwyn Kobasa
Publikováno v:
Viruses, Vol 15, Iss 1, p 85 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) that has caused a pandemic with millions of human infections. There continues to be a pressing need to develop potential the
Externí odkaz:
https://doaj.org/article/c282f1928b30468bada1eb6ce5ae4f2a
Autor:
Anna Majer, Sarah J. Medina, Debra Sorensen, Matthew J. Martin, Kathy L. Frost, Clark Phillipson, Kathy Manguiat, Stephanie A. Booth
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Multiple cell types and complex connection networks are an intrinsic feature of brain tissue. In this study we used expression profiling of specific microscopic regions of heterogeneous tissue sections isolated by laser capture microdissecti
Externí odkaz:
https://doaj.org/article/a5215f0e0d6d49c7899b2cea69864fb5
Autor:
Lise Lamoureux, Babu Sajesh, Jessy A. Slota, Sarah J. Medina, Matthew Mayor, Kathy L. Frost, Bryce Warner, Kathy Manguiat, Heidi Wood, Darwyn Kobasa, Stephanie A. Booth
Publikováno v:
Viruses, Vol 14, Iss 6, p 1218 (2022)
The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice c
Externí odkaz:
https://doaj.org/article/c6ad9fd4d82c42a2bae92b7388f370d4
Autor:
Laura P. van Lieshout, Jakob M. Domm, Tara N. Rindler, Kathy L. Frost, Debra L. Sorensen, Sarah J. Medina, Stephanie A. Booth, James P. Bridges, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 323-329 (2018)
Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly used gene delivery vectors are those based on adeno-associated virus (AAV). Despite these
Externí odkaz:
https://doaj.org/article/2911c1cd90a04b1b9fa657f70797c3f5
Autor:
Kristyn Burak, Lise Lamoureux, Amrit Boese, Anna Majer, Reuben Saba, Yulian Niu, Kathy Frost, Stephanie A. Booth
Publikováno v:
Neurobiology of Disease, Vol 112, Iss , Pp 1-13 (2018)
The mechanisms that lead to neuronal death in neurodegenerative diseases are poorly understood. Prion diseases, like many more common disorders such as Alzheimer's and Parkinson's diseases, are characterized by the progressive accumulation of misfold
Externí odkaz:
https://doaj.org/article/603bd9576a4d48bbb0357e285080dad3