Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Stephanie A Wankowicz"'
Autor:
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce densit
Externí odkaz:
https://doaj.org/article/df7cabe4cceb4472bbdd8fd7453b61bf
Autor:
Stephanie A Wankowicz, Saulo H de Oliveira, Daniel W Hogan, Henry van den Bedem, James S Fraser
Publikováno v:
eLife, Vol 11 (2022)
While protein conformational heterogeneity plays an important role in many aspects of biological function, including ligand binding, its impact has been difficult to quantify. Macromolecular X-ray diffraction is commonly interpreted with a static str
Externí odkaz:
https://doaj.org/article/42e8ec0d84fa4d86ba8fa90a81eae627
Autor:
Siyuan Du, Stephanie A. Wankowicz, Filip Yabukarski, Tzanko Doukov, Daniel Herschlag, James S. Fraser
Publikováno v:
bioRxiv
Conformational ensembles underlie all protein functions. Thus, acquiring atomic-level ensemble models that accurately represent conformational heterogeneity is vital to deepen our understanding of how proteins work. Modeling ensemble information from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9000ca71fa40b7aafe2c85e3eda6f6
https://europepmc.org/articles/PMC10187334/
https://europepmc.org/articles/PMC10187334/
Autor:
Toni K. Choueiri, Darren Feldman, Robert J. Motzer, Sabina Signoretti, Lauren C. Harshman, James J. Hsieh, Jae Lyun Lee, Sumanta K. Pal, JoAnn Hsu, Fabio A. Schutz, Andre P. Fay, Daniel Y. Heng, J. Connor Wells, Guillermo De Velasco, Daniel Castellano, Eliezer Van Allen, David A. Braun, Xiao X. Wei, Dylan J. Martini, Aly-Khan A. Lalani, Raphael Brandao, Abdallah Flaifel, Stephanie A.M. Wankowicz, Wanling Xie, Dominick Bossé, Rana R. McKay
Programmed death 1 (PD-1) and PD ligand 1 (PD-L1) inhibitors have shown activity in metastatic clear cell renal cell carcinoma (ccRCC). Data on the activity of these agents in patients with non–clear cell RCC (nccRCC) or patients with sarcomatoid/r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7a3b136f17fc5d33e77f0d7330319b
https://doi.org/10.1158/2326-6066.c.6549214.v1
https://doi.org/10.1158/2326-6066.c.6549214.v1
Autor:
Toni K. Choueiri, Darren Feldman, Robert J. Motzer, Sabina Signoretti, Lauren C. Harshman, James J. Hsieh, Jae Lyun Lee, Sumanta K. Pal, JoAnn Hsu, Fabio A. Schutz, Andre P. Fay, Daniel Y. Heng, J. Connor Wells, Guillermo De Velasco, Daniel Castellano, Eliezer Van Allen, David A. Braun, Xiao X. Wei, Dylan J. Martini, Aly-Khan A. Lalani, Raphael Brandao, Abdallah Flaifel, Stephanie A.M. Wankowicz, Wanling Xie, Dominick Bossé, Rana R. McKay
Includes: Table 1S. Baseline patient and disease characteristics. Table 2S. Tumor mutation burden status. Table 3S. PDL1 expression data. Figure 1S. Overall survival for the total cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050a1b150ce3998dd89220d1a3afb6e9
https://doi.org/10.1158/2326-6066.22539886.v1
https://doi.org/10.1158/2326-6066.22539886.v1
Autor:
David J. Kwiatkowski, Gad Getz, Eliezer M. Van Allen, Henry W. Long, Paloma Cejas, Mary-Ellen Taplin, Kent W. Mouw, Silvia Hernandez, Josep Lloreta-Trull, Nuria Juanpere, Inés de Torres, Juan Morote, Justine A. Barletta, Michaela Bowden, Stephanie A. Wankowicz, Alejo Rodriguez-Vida, Anna Orsola, Júlia Perera-Bel, Brendan Reardon, Jaegil Kim, Joaquim Bellmunt
High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non–muscle-invasive bladder cancer with unpredictable outcome and poorly understood risk factors. Here, we examined the association of somatic mutation profiles with nonrecurrent di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106a3da1c4ae756831d98851315c327b
https://doi.org/10.1158/0008-5472.c.6512317
https://doi.org/10.1158/0008-5472.c.6512317
Autor:
Eliezer M. Van Allen, Theodore S. Hong, Ryan B. Corcoran, Henning Willers, Scott L. Carter, Jennifer Y. Wo, Adam Tracy, Emily E. Van Seventer, Stephanie A. Wankowicz, Brendan Reardon, David Liu, Claire A. Margolis, Jochen K. Lennerz, Sophia C. Kamran
Supplemental Figures 1-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5994882cb1a542918ae52294a6bb2dc1
https://doi.org/10.1158/1078-0432.22475883
https://doi.org/10.1158/1078-0432.22475883
Autor:
David J. Kwiatkowski, Gad Getz, Eliezer M. Van Allen, Henry W. Long, Paloma Cejas, Mary-Ellen Taplin, Kent W. Mouw, Silvia Hernandez, Josep Lloreta-Trull, Nuria Juanpere, Inés de Torres, Juan Morote, Justine A. Barletta, Michaela Bowden, Stephanie A. Wankowicz, Alejo Rodriguez-Vida, Anna Orsola, Júlia Perera-Bel, Brendan Reardon, Jaegil Kim, Joaquim Bellmunt
Supplementary figures, tables, material & methods and results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045b5cee9881419085a776439fc4b154
https://doi.org/10.1158/0008-5472.22426366
https://doi.org/10.1158/0008-5472.22426366
Autor:
Eliezer M. Van Allen, Theodore S. Hong, Ryan B. Corcoran, Henning Willers, Scott L. Carter, Jennifer Y. Wo, Adam Tracy, Emily E. Van Seventer, Stephanie A. Wankowicz, Brendan Reardon, David Liu, Claire A. Margolis, Jochen K. Lennerz, Sophia C. Kamran
IHC Antibody Details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcf29287e00fa83f26bac4ab85b69b5
https://doi.org/10.1158/1078-0432.22475880.v1
https://doi.org/10.1158/1078-0432.22475880.v1
Autor:
Eliezer M. Van Allen, Theodore S. Hong, Ryan B. Corcoran, Henning Willers, Scott L. Carter, Jennifer Y. Wo, Adam Tracy, Emily E. Van Seventer, Stephanie A. Wankowicz, Brendan Reardon, David Liu, Claire A. Margolis, Jochen K. Lennerz, Sophia C. Kamran
Supplemental Figure Captions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a581580ff4291aaa318d94feb4b86b8f
https://doi.org/10.1158/1078-0432.22475874
https://doi.org/10.1158/1078-0432.22475874