CD1d expression demarcates CDX4+ hemogenic mesoderm with definitive hematopoietic potential

Autor: J. Philip Creamer, Stephanie A. Luff, Hao Yu, Christopher M. Sturgeon

Publikováno v: Stem Cell Research, Vol 62, Iss , Pp 102808- (2022)

To achieve efficient, reproducible differentiation of human pluripotent stem cells (hPSCs) towards specific hematopoietic cell-types, a comprehensive understanding of the necessary cell signaling and developmental trajectories involved is required. P

Externí odkaz: https://doaj.org/article/c4fb56483b48417cafff9d9309fc9992

Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis.

Autor: Stephanie A Luff, Chen-Yuan Kao, Eleftherios T Papoutsakis

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203991 (2018)

Megakaryocytes (Mks) derive from hematopoietic stem and progenitor cells (HSPCs) in the bone marrow and develop into large, polyploid cells that eventually give rise to platelets. As Mks mature, they migrate from the bone marrow niche into the vascul

Externí odkaz: https://doaj.org/article/907f452e87ad4c728296aa8d86ef445e

Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells

Autor: Stephanie A. Luff, J. Philip Creamer, Sara Valsoni, Carissa Dege, Rebecca Scarfò, Analisa Dacunto, Sara Cascione, Lauren N. Randolph, Eleonora Cavalca, Ivan Merelli, Samantha A. Morris, Andrea Ditadi, Christopher M. Sturgeon

Publikováno v: Nature cell biology 24 (2022): 616–+. doi:10.1038/s41556-022-00898-9
info:cnr-pdr/source/autori:Luff, Stephanie A.; Creamer, J. Philip; Valsoni, Sara; Dege, Carissa; Scarfo, Rebecca; Dacunto, Analisa; Cascione, Sara; Randolph, Lauren N.; Cavalca, Eleonora; Merelli, Ivan; Morris, Samantha A.; Ditadi, Andrea; Sturgeon, Christopher M./titolo:Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells/doi:10.1038%2Fs41556-022-00898-9/rivista:Nature cell biology/anno:2022/pagina_da:616/pagina_a:+/intervallo_pagine:616–+/volume:24

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs derive from haemogenic endothelium (HE) in a NOTCH- and retinoic acid (RA)-depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c7a8059e84cddfa73f22fec5797134
https://pubmed.ncbi.nlm.nih.gov/35484246

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development

Autor: Stephanie A. Luff, Carissa Dege, Katherine H. Fegan, Melissa M. Berrien-Elliott, Darren Kim, James Palis, Todd A. Fehniger, J. Philip Creamer, Kathleen E. McGrath, Christopher M. Sturgeon, Julia A. Wagner, Paul D. Kingsley

Publikováno v: Dev Cell

Summary Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises from Hoxaneg/low Kit+CD41+CD16/32+ hematopoietic-stem-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d22bbbce1101d2c20952015f8bb5b5d
https://pubmed.ncbi.nlm.nih.gov/32197069

Generation of Retinoic Acid-Dependent Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Autor: Andrea Ditadi, Christopher M. Sturgeon, Samantha A. Morris, J. Philip Creamer, Rebecca Scarfò, Stephanie A. Luff, Carissa Dege

Publikováno v: Blood. 136:35-35

The generation of the hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. In the embryo, HSCs derive from a HOXA+ population known as hemogenic endothelium (HE) in a retinoic acid (RA)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d30cce6ea026e660b30c7e45f443def
https://doi.org/10.1182/blood-2020-142468