Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephanie A Conos"'
Autor:
Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine Hall, Angelina J. Vince, Simon M. Chatfield, Damian B. D’Silva, Kenneth C. Pang, Kate Schroder, John Silke, David L. Vaux, Philipp J. Jost, James E. Vince
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 668-682 (2017)
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP
Externí odkaz:
https://doaj.org/article/b2bf45d4cadc4d619c18b1853295fdda
Autor:
Hazel Tye, Stephanie A. Conos, Tirta M. Djajawi, Nasteho Abdoulkader, Isabella Y. Kong, Helene L. Kammoun, Vinod K. Narayana, Mary Speir, Timothy A. Gottschalk, Jack Emery, Daniel S. Simpson, Cathrine Hall, Angelina J. Vince, Sophia Russo, Rhiannan Crawley, Maryam Rashidi, Joanne M. Hildebrand, James M. Murphy, Lachlan Whitehead, David P. De Souza, Seth L. Masters, Edwin D. Hawkins, Andrew J. Murphy, James E. Vince, Kate E. Lawlor
Cell death frequently occurs in the pathogenesis of obesity and non-alcoholic fatty liver disease (NAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined. Here, we showviathe direct comparis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e6a1f9b0da98a3b47b265262051bbd
https://doi.org/10.1101/2023.03.14.532682
https://doi.org/10.1101/2023.03.14.532682
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 646 (2021)
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutat
Externí odkaz:
https://doaj.org/article/35afe3e239d442079e0f40b3302f3ac8
Autor:
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien‐Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vince
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090d818aad756e60b516867a6ee92d87
https://doi.org/10.15252/embj.2021110468
https://doi.org/10.15252/embj.2021110468
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 646, p 646 (2021)
Biomolecules, Vol 11, Iss 646, p 646 (2021)
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aef1c61669f9eb4194157abe15513f1
https://pubmed.ncbi.nlm.nih.gov/33924766
https://pubmed.ncbi.nlm.nih.gov/33924766
Autor:
Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince
Publikováno v:
Immunity. 55:423-441.e9
Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires macrophage-intrinsic death ligands and caspase-8 enzymatic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ef5d2cfbb8fede32adef87b669aebf
https://doi.org/10.1016/j.immuni.2022.01.003
https://doi.org/10.1016/j.immuni.2022.01.003
Autor:
Philipp J. Jost, Angelina J. Vince, Stephanie A. Conos, Yifan Zhan, Kate Schroder, David L. Vaux, Simon M Chatfield, Monica Yabal, Carina Graß, Stephanie Ziehe, John Silke, Kaiwen W. Chen, Kate E. Lawlor, Ken C Pang, Tan A. Nguyen, James E Vince, Damian B D'Silva, Rebecca Feltham, Cathrine Hall
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 668-682 (2017)
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1fae4e64ebe36a9482ee87e3e83aca
http://www.sciencedirect.com/science/article/pii/S221112471730904X
http://www.sciencedirect.com/science/article/pii/S221112471730904X
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1714
Cell death results in the breakdown of the plasma membrane, which can cause the release of cytosolic proteins. During caspase-1-mediated cell death, termed pyroptosis, pro-inflammatory mediators that lack canonical secretory signal sequences, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05b3c585ec925f19c74a91b954543765
https://pubmed.ncbi.nlm.nih.gov/29177866
https://pubmed.ncbi.nlm.nih.gov/29177866
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975181
Cell death results in the breakdown of the plasma membrane, which can cause the release of cytosolic proteins. During caspase-1-mediated cell death, termed pyroptosis, pro-inflammatory mediators that lack canonical secretory signal sequences, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bb2bc9e259b29cc7e52971c2d5f358
https://doi.org/10.1007/978-1-4939-7519-8_15
https://doi.org/10.1007/978-1-4939-7519-8_15
Publikováno v:
Trends in molecular medicine. 24(1)
Inflammatory signaling underlies many diseases, from arthritis to cancer. Our understanding of inflammation has thus far been limited to the world of proteins, because we are only just beginning to understand the role that noncoding RNAs (ncRNA) migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338b113f96ada23fbcf9e757785ad7c5
https://pubmed.ncbi.nlm.nih.gov/29246760
https://pubmed.ncbi.nlm.nih.gov/29246760