Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Stephanie, Zandee"'
Autor:
Sienna S. Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klement, Jo Anne Stratton, Alexandre Prat, Stephanie Zandee, Alyson E. Fournier
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegenera
Externí odkaz:
https://doaj.org/article/07e09c6af8784c0bbef1de4e6dc3cbe6
Autor:
Samantha F. Kornfeld, Sarah E. Cummings, Rebecca Yaworski, Yves De Repentigny, Sabrina Gagnon, Stephanie Zandee, Samaneh Fathi, Alexandre Prat, Rashmi Kothary
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelina
Externí odkaz:
https://doaj.org/article/44c7ebcf25614e2aabf92ea59d7493d9
Autor:
Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat, Samuel David
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is thought to play a crucial role in progressive forms of multiple
Externí odkaz:
https://doaj.org/article/18aee7bd8ba0455cb2561b0275634eaa
Autor:
Michael S. LaCroix, Hilda Mirbaha, Ping Shang, Stephanie Zandee, Chan Foong, Alexandre Prat, Charles L. White, Olaf Stuve, Marc I. Diamond
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-7 (2022)
Abstract Relapsing remitting multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system that in many cases leads to progressive MS, a neurodegenerative disease. Progressive MS is untreatable and relentless, and it
Externí odkaz:
https://doaj.org/article/2b41cf94047942ab9711e3f23b2e3533
Autor:
Alba Sánchez-Fernández, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat, Rubèn López-Vales
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordin
Externí odkaz:
https://doaj.org/article/cdf4d8835a9a4105982a5453884f0a42
Autor:
Marc Charabati, Stephanie Zandee, Antoine P Fournier, Olivier Tastet, Karine Thai, Roxaneh Zaminpeyma, Marc-André Lécuyer, Lyne Bourbonnière, Sandra Larouche, Wendy Klement, Camille Grasmuck, Fiona Tea, Bettina Zierfuss, Ali Filali-Mouhim, Robert Moumdjian, Alain Bouthillier, Romain Cayrol, Evelyn Peelen, Nathalie Arbour, Catherine Larochelle, Alexandre Prat
Publikováno v:
Brain. 146:1483-1495
The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with the infil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc336d30eeb0f8febc94fb723d174b8
https://doi.org/10.1093/brain/awac389
https://doi.org/10.1093/brain/awac389
Autor:
Valeria Ramaglia, Salma Sheikh-Mohamed, Karen Legg, Calvin Park, Olga L Rojas, Stephanie Zandee, Fred Fu, Olga Ornatsky, Eric C Swanson, David Pitt, Alexandre Prat, Trevor D McKee, Jennifer L Gommerman
Publikováno v:
eLife, Vol 8 (2019)
Multiple sclerosis (MS) is characterized by demyelinated and inflammatory lesions in the brain and spinal cord that are highly variable in terms of cellular content. Here, we used imaging mass cytometry (IMC) to enable the simultaneous imaging of 15+
Externí odkaz:
https://doaj.org/article/6def8078950146e587285cba613947c2
Autor:
Yifei Dong, Rajiv W. Jain, Brian M. Lozinski, Charlotte D’Mello, Frank Visser, Samira Ghorbani, Stephanie Zandee, Dennis I. Brown, Alexandre Prat, Mengzhou Xue, V. Wee Yong
Publikováno v:
Nature Aging. 2:508-525
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4bae777e3bb26537f7dd04ecd4a6d96
https://doi.org/10.1038/s43587-022-00205-z
https://doi.org/10.1038/s43587-022-00205-z
Autor:
Valeria Ramaglia, Jennifer Y. Yam, Camille Grasmuck, Dennis S. W. Lee, Laure Michel, Lyne Bourbonnière, Lesley A. Ward, Amit Bar-Or, Alexandre Prat, Dragos Dasoveanu, Jennifer L. Gommerman, Olga L. Rojas, Stephanie Zandee
Publikováno v:
The Journal of Immunology. 207:1513-1521
B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and subsequent migration to the CNS remain incompletely understood. We previously showed that systemic inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27deb72bf1d43d11a86ffde831c30220
https://doi.org/10.4049/jimmunol.2001413
https://doi.org/10.4049/jimmunol.2001413
Autor:
Qiubo Jiang, Brian O'Nuallain, Clemens R. Scherzer, Eve C. Tsai, Jennifer A. Chan, Peggy Taylor, John Woulfe, An Tran, Ming Jin, Steve M. Callaghan, Gary S. Shaw, Masashi Takanashi, Bojan Shutinoski, Mei Zhang, Jacqueline M. Tokarew, Jasmine M. Khan, Nobutaka Hattori, Daniel N. El-Kodsi, Luigi Zecca, Alexandre Prat, Andrew B. West, Andy C. H. Ng, Xiajun Dong, Juan Li, Travis K. Fehr, Liqun Wang, Nathalie A. Lengacher, Angela P. Nguyen, David S. Park, Doo Soon Im, Julianna J. Tomlinson, Gergely Tóth, Michael G. Schlossmacher, Kathryn R. Barber, Lawrence G. Puente, Arne Holmgren, Stephanie Zandee, Rajib Sengupta
Publikováno v:
Acta Neuropathologica
The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are reflected in its posttranslational modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8c45df270412089e53128defbb6048
http://europepmc.org/articles/PMC8043881
http://europepmc.org/articles/PMC8043881