Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stephanie, Harlfinger"'
Autor:
Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87689f9fe496e8ff4e8b8008d72b261f
https://doi.org/10.1002/cmdc.202300051
https://doi.org/10.1002/cmdc.202300051
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb2a4d859543d18252213a2d5a9b54c
https://doi.org/10.1021/acs.jmedchem.2c00369
https://doi.org/10.1021/acs.jmedchem.2c00369
Autor:
Tobias Schmelzle, Emilie Chapeau, Daniel Bauer, Patrick Chene, Jason Faris, Cesar Fernandez, Pascal Furet, Giorgio Galli, Jiachang Gong, Stephanie Harlfinger, Francesco Hofmann, Eloisa Jimenez Nunez, Joerg Kallen, Thanos Mourikis, Laurent Sansregret, Paulo Santos, Clemens Scheufler, Holger Sellner, Markus Voegtle, Markus Wartmann, Peter Wessels, Frederic Zecri, Nicolas Soldermann
Publikováno v:
Cancer Research. 83:LB319-LB319
The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting YAP-TEAD oncogenic function do so by engaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad77e2db1f0369ac9729c839360bd713
https://doi.org/10.1158/1538-7445.am2023-lb319
https://doi.org/10.1158/1538-7445.am2023-lb319
Autor:
Tashinga E. Bapiro, Scott Martin, Stephen D Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger, Dermot F McGinnity
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012c7e50c11486943a74a394d0b4eb43
https://doi.org/10.1124/dmd.123.001323
https://doi.org/10.1124/dmd.123.001323
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Scott, Boyd, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Nichola L, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Lyndsey, Hanson, Stephanie, Harlfinger, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Gillian, Lamont, Scott, Lamont, Hilary J, Lewis, Libin, Liu, Michael J, Niedbala, Christopher, Phillips, Radek, Polanski, Piotr, Raubo, Graeme, Robb, David M, Robinson, Sarah, Ross, Matthew G, Sanders, Michael, Tonge, Rebecca, Whiteley, Stephen, Wilkinson, Junsheng, Yang, Wenman, Zhang
Publikováno v:
Journal of medicinal chemistry. 65(9)
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based drug design appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c82ffa8ba3350b52cfb57034d024ef1
https://pubmed.ncbi.nlm.nih.gov/35471939
https://pubmed.ncbi.nlm.nih.gov/35471939
Publikováno v:
Drug Discovery Today. 25:1793-1800
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality with the potential to open target space not accessible to conventional small molecules via a degradation-based mechanism; however, their bifunctional nature can result in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b90be2147c5934da0dd545cc49b03
https://doi.org/10.1016/j.drudis.2020.07.013
https://doi.org/10.1016/j.drudis.2020.07.013
Publikováno v:
Drug Metabolism and Disposition. 48:1137-1146
The use of in vitro in vivo extrapolation (IVIVE) from human hepatocyte (HH) and human liver microsome (HLM) stability assays is a widely accepted predictive methodology for human metabolic clearance (CLmet). However, a systematic underprediction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee63503e9e698986d5025960432a99
https://doi.org/10.1124/dmd.120.000131
https://doi.org/10.1124/dmd.120.000131
Autor:
Strang Ross Sinclair, Markus Streiff, Daniel J. McKay, Johannes Ottl, Andreas Billich, Claudia Betschart, Stephanie Harlfinger, Eloísa Jiménez-Núñez, Nigel Graham Cooke, Christine Guntermann, Markus Voegtle, Janet Dawson, Samuel Hintermann, Klemens Kaupmann, Rowan Stringer, Christian Beerli, Nathalie Gobeau, Juergen Wagner, Klemens Hoegenauer, Joerg Kallen, Peter Ertl
Publikováno v:
Journal of Medicinal Chemistry. 62:10816-10832
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) is considered to be the master transcription factor for the development of Th17 cells that produce proinflammatory cytokines such as IL-17A. Overproportionate Th17 cell abundance is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1edf6050ac20e08d84ef25cb7a5c6f4c
https://doi.org/10.1021/acs.jmedchem.9b01291
https://doi.org/10.1021/acs.jmedchem.9b01291
Autor:
Geeti Gangal, Sonke Svenson, Chester A. Metcalf, Pochi Shum, Snehlata Tripathi, Jungyeon Hwang, Stephanie Harlfinger, Beata Sweryda-Krawiec, Roy I. Case, Douglas Lazarus, Derek van der Poll, Sujan Kabir, Donna Brown, Ellen Rohde, Chi-Hse Teng, Roderic O. Cole, Scott Eliasof
Publikováno v:
Journal of Medicinal Chemistry. 62:9541-9559
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27195bb3a1196c25d218ec36152dd0c0
https://doi.org/10.1021/acs.jmedchem.9b00892
https://doi.org/10.1021/acs.jmedchem.9b00892
Autor:
Amanda Littlewood-Evans, Simona Cotesta, Philipp Janser, Rochdi Bouhelal, Rowan Stringer, Stephanie Harlfinger, Philippe Piechon, Rainer Wilcken, Matthias Haffke, Fabian Piller, Frederic Villard, Dominique Fehlmann, Trixie Wagner, Klemens Kaupmann, Achim Schlapbach, Nina Gommermann, Juraj Velcicky
Publikováno v:
Journal of medicinal chemistry. 63(17)
G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity. Here, we describe a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e04b8678f9f63ad66e38607af8c753
https://pubmed.ncbi.nlm.nih.gov/32856916
https://pubmed.ncbi.nlm.nih.gov/32856916