Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephania Widger"'
Autor:
Xiaolei Ma, Barbara Leon, Elizabeth Ornelas, Dustin Dovala, Laura Tandeske, Catherine Luu, Gwynn Pardee, Stephania Widger, Jonathan M. Solomon, Rohan E. J. Beckwith, Heinz Moser, Matthew C. Clifton, Charles A. Wartchow
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of significant interest when designing therapeutic agents. Previous studies show that SALL4 is degra
Externí odkaz:
https://doaj.org/article/9ec871d57f274caeacf1b5e0701bf9f6
Autor:
Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://doaj.org/article/935bc8e9e098406ea024047d133a1803
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Figure 4. Growth of individual tumors shown in Fig. 7A-C are given for HCT 116 (A), MIA PaCa-2 (B) and MEL-JUSO (C) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2175679541bcf9cea1bfe131eae3dc26
https://doi.org/10.1158/1078-0432.22480680
https://doi.org/10.1158/1078-0432.22480680
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
p-ERK MSD results in RAS mutant cells ectopically expressed ARAF variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a06d1625834f006100db5b3daf5cfda
https://doi.org/10.1158/1078-0432.22480659
https://doi.org/10.1158/1078-0432.22480659
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Purpose:Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254.Experimental Design:LXH254 was profiled in biochemical, in vitro, and in vivo assays,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1b1fef6c36ab7ea76ff43f5c11d34
https://doi.org/10.1158/1078-0432.c.6530499.v1
https://doi.org/10.1158/1078-0432.c.6530499.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703cf919309a8d21ff2ef43d79a39ca5
https://doi.org/10.1158/1078-0432.22480674.v1
https://doi.org/10.1158/1078-0432.22480674.v1
Autor:
Peter S. Hammerman, Jing Yuan, Lesley A. Mathews Griner, Peter Aspesi, Daniel J. McKay, Gwynn Pardee, Hui Qin Wang, Kelli-Ann Monaco, Ribo Guo, Kenneth Crawford, Stephania Widger, Darrin Stuart, Vesselina G. Cooke, Karen Bui, Felipa A. Mapa, Yuji Mishina, Mariela Jaskelioff, Jeffrey A. Engelman, Paul Fordjour, Emma Labrot, Giordano Caponigro, Stacy Higgins, Jessi Ambrose, John Fuller, Jinsheng Liang, John Green, Scott Delach
Publikováno v:
Clinical Cancer Research. 27:2061-2073
Purpose: Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254. Experimental Design: LXH254 was profiled in biochemical, in vitro, and in vivo assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aeeab439f64334a9ace3edb9d3a375
https://doi.org/10.1158/1078-0432.ccr-20-2563
https://doi.org/10.1158/1078-0432.ccr-20-2563
Autor:
Isabel Zaror, Kenneth Crawford, Mohammad Hekmat-Nejad, Stephania Widger, Janet Sim, Hanne Merritt, Kelly Yan, Gwynn Pardee, Jan Marie Cheng
Publikováno v:
Protein Expression and Purification. 110:172-179
Extracellular signal-regulated kinase 2 (ERK2) is a serine/threonine protein kinase involved in many cellular programs, such as cell proliferation, differentiation, motility and programed cell-death. It is therefore considered an important target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1157838202e0204f1849084f6bd4179
https://doi.org/10.1016/j.pep.2015.03.010
https://doi.org/10.1016/j.pep.2015.03.010
Autor:
Aurélie Winterhalter, Sharadha Subramanian, Tiffany Tsang, Jean-Michel Florent, Stephen F. Hardy, Laura Tandeske, Armin Widmer, Arndt Meyer, Johanna M. Jansen, Charles Wartchow, S. Rieffel, Stephania Widger, Yumin Dai, Tatiana Zavorotinskaya, Savithri Ramurthy, Dove Jeffrey H, Yun Feng, Julia Klopp, Isabel Zaror, Kenneth Crawford, Alvar D. Gossert, Susan Fong, Darrin Stuart, Yuji Mishina, John Fuller, Gwynn Pardee, Andreas Lingel, Lenahan William P, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Eric Fang, Dirksen E. Bussiere, Sylvia Ma, Wolfgang Jahnke, Jan Marie Cheng, Chrystèle Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
PLoS ONE, 12 (4)
PLoS ONE
PLoS ONE, 12 (4)
PLoS ONE
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74adeb6145df8376b86b98aae0c5870
http://europepmc.org/articles/PMC5383040?pdf=render
http://europepmc.org/articles/PMC5383040?pdf=render
Autor:
Alvar D. Gossert, Dove Jeffrey H, Sharadha Subramanian, Susan Fong, Bill Lenahan, Gwynn Pardee, Simona Gokhin, Andreas Lingel, Arndt Meyer, Savithri Ramurthy, Laura Tandeske, David Farley, Charles Wartchow, Tatiana Zavorotinskaya, Julia Klopp, John Fuller, Kevin Shoemaker, Eric Fang, Anke Blechschmidt, Yumin Dai, Chrystèle Henry, Isabel Zaror, Dirksen E. Bussiere, Wolfgang Jahnke, Jean-Michel Florent, C. Gregory Paris, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Johanna M. Jansen, Stephen F. Hardy, Armin Widmer, Stephania Widger, Tiffany Tsang, Paul A. Renhowe, S. Rieffel
Publikováno v:
Molecular Cancer Research. 12:B38-B38
Mutated forms of KRAS are no longer able to switch effectors between “on” and “off” states. It is known that the function of KRAS is controlled by key parts in the C-terminus, including six consecutive lysines, a terminal prenyl moiety and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da1dadaf490935832bd212e91663a65
https://doi.org/10.1158/1557-3125.rasonc14-b38
https://doi.org/10.1158/1557-3125.rasonc14-b38