Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stephane de Cesco"'
Autor:
Toon Laeremans, Zara A. Sands, Pieter Claes, Ann De Blieck, Stephane De Cesco, Sarah Triest, Andreas Busch, David Felix, Abhinav Kumar, Veli-Pekka Jaakola, Christel Menet
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug
Externí odkaz:
https://doaj.org/article/ea4599d8f7de44b08618672b548d1833
Autor:
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E. Brennan, Ivan Ahel
Publikováno v:
Pathogens, Vol 12, Iss 2, p 324 (2023)
The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies. The NSP3 macrod
Externí odkaz:
https://doaj.org/article/d095de8ed820404392759fd4296b33f6
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232644 (2020)
When trying to identify new potential therapeutic protein targets, access to data and knowledge is increasingly important. In a field where new resources and data sources become available every day, it is crucial to be able to take a step back and lo
Externí odkaz:
https://doaj.org/article/6d4e15cafb6d4933858ad78b832e3499
Autor:
Justin M. Di Trani, Stephane De Cesco, Rebecca O’Leary, Jessica Plescia, Claudia Jorge do Nascimento, Nicolas Moitessier, Anthony K. Mittermaier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
There is growing evidence that the kinetics of interactions between inhibitors and their targets can strongly impact therapeutic efficacy. Here the authors describe an isothermal titration calorimetry-based method that can rapidly quantify inhibition
Externí odkaz:
https://doaj.org/article/695ef23f7e8d4d87a44cc9ad450d7ebc
Autor:
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety. Brain-produced hormones such as α-
Externí odkaz:
https://doaj.org/article/f05dbb65117040f98bbf56edfbe2bf19
Publikováno v:
Journal of Medicinal Chemistry. 63:10158-10169
An increasing number of new drugs have their origin in small biotech or academia. In contrast to big pharma, these environments are often more limited in terms of resources, and this necessitates different approaches to the drug discovery process. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c56ccfaf616f2907928276e3d568f35
https://doi.org/10.1021/acs.jmedchem.9b02126
https://doi.org/10.1021/acs.jmedchem.9b02126
Autor:
Stephane de Cesco, Daniel Williams, Lucy V Morris, Lina Y El-Sharkawy, Tessa Swanton, Halah Hammadi, Catherine B. Lawrence, Jack Peter Green, David Brough, Shi Yu, Sally Freeman, James A Beswick, John B. Davis
Publikováno v:
Swanton, T, Beswick, J, Hammadi, H, Morris, L, Williams, D, De Cesco, S, El-sharkawy, L, Yu, S, Green, J, Davis, J, Lawrence, C, Brough, D & Freeman, S 2020, ' Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl-channel modulation ', Chemical Science, vol. 11, no. 43, pp. 11720-11728 . https://doi.org/10.1039/D0SC03828H
Chemical Science
Chemical Science
The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a8b9179397a434db4dd5074272628
https://doi.org/10.1039/d0sc03828h
https://doi.org/10.1039/d0sc03828h
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0232644 (2020)
PLoS ONE, Vol 15, Iss 9, p e0232644 (2020)
When trying to identify new potential therapeutic protein targets, access to data and knowledge is increasingly important. In a field where new resources and data sources become available every day, it is crucial to be able to take a step back and lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d7dde9444294e55d748bf7e2eefd4
https://doi.org/10.1371/journal.pone.0232644
https://doi.org/10.1371/journal.pone.0232644