Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Stephane Wong"'
Autor:
Raquel De Paz, Carla Boquimpani, Sandip Acharya, Sikander Ailawadhi, Stephane Wong, Noam Benyamini, Franck E. Nicolini, Nelma Cristina D. Clementino, Jolanta Dengler, Rafik Fellague-Chebra, Dong-Wook Kim, Tomasz Sacha, Vasily Shuvaev, Yu Jin, Beatriz Moiraghi, Timothy P. Hughes, Jeffrey H. Lipton, Anna G. Turkina, Naoto Takahashi, François Xavier Mahon
Background Treatment-free remission (TFR)-that is, stopping tyrosine kinase inhibitor (TKI) therapy without loss of response-is an emerging treatment goal in chronic myeloid leukemia (CML). Objective To evaluate TFR after discontinuation of second-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d655cde82d6e2165924782619e45053
https://ruj.uj.edu.pl/xmlui/handle/item/93617
https://ruj.uj.edu.pl/xmlui/handle/item/93617
Autor:
Özlem Anak, Ulrich Jaeger, Constantine S. Tam, Stephen J. Schuster, Rakesh Awasthi, Eric Bleickardt, Susana Rives, Michael Boyer, André Baruchel, Shannon L. Maude, Gregory A. Yanik, Michael R. Bishop, Peter Borchmann, Edmund K. Waller, Edward Waldron, Lida Bubuteishvili Pacaud, Stephane Wong, G.D. Myers, Karen Thudium Mueller, Heather E. Stefanski, Abhijit Chakraborty, Michael A. Pulsipher, Joseph P. McGuirk
Publikováno v:
Cancer Research. 79:CT237-CT237
Background: Following infusion of tisagenlecleucel, quantitative polymerase chain reaction (qPCR) can be used to measure in vivo kinetics of CAR transgene. The utility of qPCR to inform individual pt treatment decisions and measure functional persist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3677ce1d2702ade4826d339cfdd37e69
https://doi.org/10.1158/1538-7445.am2019-ct237
https://doi.org/10.1158/1538-7445.am2019-ct237
Autor:
Michael A. Pulsipher, Xia Han, Máire Quigley, Gabor Kari, Susana Rives, Theodore W. Laetsch, Gary D. Myers, Hidefumi Hiramatsu, Gregory A. Yanik, Muna Qayed, Timothy Driscoll, Michael W. Boyer, Heather Stefanski, Jochen Buchner, Andre Baruchel, Peter Bader, Lan Yi, Creton Kalfoglou, Harlan Robins, Erik Yusko, Gullu Gorgun, Eric Bleickardt, Stephane Wong, Stephan A. Grupp
Publikováno v:
Cancer Research. 79:CT077-CT077
Background: Detection of MRD is an important predictor of patient outcome following treatment of B-ALL; importantly, MRD is emerging as a useful tool to detect early relapse, which may fulfill a key previously unmet clinical need. Objective: To evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931187881b2297f47f07faf524ace8ca
https://doi.org/10.1158/1538-7445.am2019-ct077
https://doi.org/10.1158/1538-7445.am2019-ct077
Autor:
Michael A. Pulsipher, Hidefumi Hiramatsu, G.D. Myers, Gregory A. Yanik, Gabor Kari, Muna Qayed, Heather E. Stefanski, Harlan Robins, Susana Rives, André Baruchel, Theodore W. Laetsch, Peter Bader, Stephan A. Grupp, Eric Bleickardt, Michael Boyer, Jochen Büchner, Erik Yusko, Xia Han, Lan Yi, Timothy A. Driscoll, Gullu Gorgun, Creton Kalfoglou, Stephane Wong, Máire F. Quigley
Publikováno v:
Blood. 132:1551-1551
Introduction Detection of minimal residual disease (MRD) is an important predictor of patient outcome following treatment of B-cell acute lymphoblastic leukemia (B-ALL). We assessed concordance between two MRD assays, with different assay sensitiviti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc91fc825ffea53ce6c4abf7111a6c4
https://doi.org/10.1182/blood-2018-99-115460
https://doi.org/10.1182/blood-2018-99-115460
Autor:
Eric Bleickardt, Michael R. Bishop, Michael Boyer, Ulrich Jaeger, Susana Rives, Hyatt Balke-Want, Abhijit Chakraborty, Stephen J. Schuster, Stephane Wong, Shannon L. Maude, Gregory A. Yanik, Edward Waldron, G.D. Myers, Edmund K. Waller, Constantine S. Tam, Karen Thudium Mueller, Lida Bubuteishvili Pacaud, Michael A. Pulsipher, André Baruchel, Rakesh Awasthi, Heather E. Stefanski, Joseph P. McGuirk, Özlem Anak
Publikováno v:
Blood. 132:899-899
Background Quantitative polymerase chain reaction (qPCR) is an analytical method that has been used to investigate the in vivo kinetics of chimeric receptor antigen (CAR) transgene following the infusion of tisagenlecleucel. B cell aplasia, likely an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc84ebbacc6a784d6792a54a74a6b1f
https://doi.org/10.1182/blood-2018-99-116385
https://doi.org/10.1182/blood-2018-99-116385
Autor:
Jonathan A. Deane, David A. Fruman, Owen N. Witte, Michael G. Kharas, Naomi Rosenberg, Karen R O'Bosky, Stephane Wong
Publikováno v:
Blood. 103:4268-4275
BCR-ABL and v-ABL are oncogenic forms of the Abl tyrosine kinase that can cause leukemias in mice and humans. ABL oncogenes trigger multiple signaling pathways whose contribution to transformation varies among cell types. Activation of phosphoinositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c981b488f597695a5b3b6a20d58a432
https://doi.org/10.1182/blood-2003-07-2193
https://doi.org/10.1182/blood-2003-07-2193
Autor:
Stephane Wong, Owen N. Witte
Publikováno v:
Annual Review of Immunology. 22:247-306
The twenty-first century is beginning with a sharp turn in the field of cancer therapy. Molecular targeted therapies against specific oncogenic events are now possible. The BCR-ABL story represents a notable example of how research from the fields of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78705b086c588d9bc579e2a8ee9c18c7
https://doi.org/10.1146/annurev.immunol.22.012703.104753
https://doi.org/10.1146/annurev.immunol.22.012703.104753
Publikováno v:
Blood. 101:4088-4097
Acute BCR-ABL expression during in vitro hematopoietic development of embryonic stem (ES) cells causes expansion of multipotent and myeloid progenitors with a concomitant reduction in differentiation toward erythroblasts. Progenitor cell expansion is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f807746d0f5f9500a40eb7bddb6bc07
https://doi.org/10.1182/blood-2002-11-3376
https://doi.org/10.1182/blood-2002-11-3376
Autor:
Stephane Wong, Owen N. Witte
Publikováno v:
Oncogene. 20:5644-5659
The Ph chromosome has been genetically linked to CML and ALL. Its chimeric fusion gene product, BCR-ABL, can generate leukemia in mice. This review will discuss selected model systems developed to study BCR-ABL induced leukemia and focuses on what we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f1ee1606a88794fee5372af667d1e3
https://doi.org/10.1038/sj.onc.1204638
https://doi.org/10.1038/sj.onc.1204638
Publikováno v:
Proceedings of the National Academy of Sciences. 97:12233-12238
Cellular transformation by the BCR/ABL oncogene depends on the ABL-encoded tyrosine kinase activity. To block BCR/ABL function, we created a unique tyrosine phosphatase by fusing the catalytic domain of SHP1 (SHP1c) to the ABL binding domain (ABD) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b5699bf45f6d67535121e7daa86a1a
https://doi.org/10.1073/pnas.210253497
https://doi.org/10.1073/pnas.210253497