Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stephane St-Onge"'
Autor:
Wei Zhongyong, Johan Broddefalk, Madeleine Antonsson, Kosrat Amin, Jörgen Jensen, Johan Ulander, Maxime Tremblay, Stephane St-Onge, Karolina Nilsson, Shujuan Jin, Anders Lehmann, Alleyn T. Plowright, Christopher Walpole, Tomaszewski Miroslaw, Hua Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:220-240
Agonists of the cannabinoid receptor 1 (CB1) have been suggested as possible treatments for a range of medical disorders including gastroesophageal reflux disease (GERD). While centrally acting cannabinoid agonists are known to produce psychotropic e
Autor:
Xuehong Luo, Xiao Hong Yu, Pourashraf Mehrnaz, Sanjay Srivastava, Dominic Salois, Cheng Yun-Xing, Kemal Payza, Christopher Walpole, Etienne Lessard, Stephane St-Onge, Tomaszewski Miroslaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1619-1624
An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of po
Autor:
Wei Zhongyong, Mirek Tomaszewski, Helene AstraZeneca R D Montreal Desfosses, Thierry Hong Groblewski, Page Daniel, Rosemarie Panetta, Etienne Lessard, Maxime Tremblay, William Brown, Stephane St-Onge, Claire Milburn, Sanjay K. Srivastava, Xiao Hong Yu, Kemal Payza, Hua Yang, Walpole Christopher, Ziping Liu
Publikováno v:
Letters in Drug Design & Discovery. 7:208-213
Autor:
Martin Coupal, Paul Jones, Lejla Hodzic, Wenhau Xiao, Edward Roberts, Andrew Griffin, Daniel Delorme, Dominic Salois, Maryse Labarre, Stephane St-Onge, Christopher Walpole, Jamie Boulet, Lars Gawell, Rico Lavoie, Joanne Butterworth, William Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5994-5998
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus
Publikováno v:
Letters in Drug Design & Discovery. 3:298-303
Autor:
William Brown, Tomaszewski Miroslaw, Etienne Lessard, Christopher Walpole, Wei Zhongyong, Hua Yang, Beha Sara, Sanjay Srivastava, Maxime Tremblay, Shi Yi Yue, Shawn Johnstone, Stephane St-Onge, Thierry Groblewski, Anne-Julie Archambault, Ziping Liu, Page Daniel
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
Cannabinoid CB1 receptor agonists exhibit potent analgesic effects in rodents and humans, but their clinical utility as analgesic drugs is often limited by centrally mediated side effects. We report herein the preparation of N-methyl-3-(tetrahydro-2H
Autor:
Jennifer M. A. Laird, Giovanni Martino, Anne Morinville, Stephane St-Onge, Chang Qing Cao, Carole Puma, Etienne Lessard, Xiao Hong Yu, Martin N. Perkins
Publikováno v:
PainReferences. 151(2)
Cannabinoids are analgesic in man, but their use is limited by their psychoactive properties. One way to avoid cannabinoid receptor subtype 1 (CB1R)-mediated central side-effects is to develop CB1R agonists with limited CNS penetration. Activation of
Autor:
Page Daniel, Christopher Walpole, François Gaudreault, Meredith Fyfe, Hua Yang, Manon Fleurent, Stephane St-Onge, William Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
The preparation and evaluation of a novel class of CB2 agonists based on a 1,2,3,4-tetrahydropyrrolo[3,4-b]indole moiety are reported. They showed binding affinities up to 4.2 nM toward CB2 with sub-nanomolar EC50 values. They also showed moderate to
Autor:
Charlotte Avet, Arturo Mancini, Billy Breton, Christian Le Gouill, Alexander S Hauser, Claire Normand, Hiroyuki Kobayashi, Florence Gross, Mireille Hogue, Viktoriya Lukasheva, Stéphane St-Onge, Marilyn Carrier, Madeleine Héroux, Sandra Morissette, Eric B Fauman, Jean-Philippe Fortin, Stephan Schann, Xavier Leroy, David E Gloriam, Michel Bouvier
Publikováno v:
eLife, Vol 11 (2022)
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are a
Externí odkaz:
https://doaj.org/article/34e18aa1566b4e768be5932a0e81dff7
Autor:
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://doaj.org/article/87187fce26ae464386af76218484bf38