Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stephane Pourpe"'
Autor:
Raquel P. Deering, Lili Blumenberg, Lianjie Li, Ankur Dhanik, Se Jeong, Stephane Pourpe, Hang Song, Lauren Boucher, Shoba Ragunathan, Yanxia Li, Maggie Zhong, Jessica Kuhnert, Christina Adler, Peter Hawkins, Namita T. Gupta, Michael Moore, Min Ni, Johanna Hansen, Yi Wei, Gavin Thurston
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limit
Externí odkaz:
https://doaj.org/article/7093cc5d822c4b288df26b94fb08b8c9
Autor:
Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes wi
Externí odkaz:
https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
Autor:
Vincent Ho, Nina Bhardwaj, Timothy Chan, Joseph Park, Stephane Pourpe, Arnab Ghosh, Cansu Cimen Bozkus, Svena Verma, William Duke, Max Jan, Matthew Leventhal, Gabriela Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R Coleman Lindsley, Hans Hasselbalch, Jacob Grauslund, Mads Andersen, Morten Holmström, Raajit Rampal, Omar Abdel-Wahab, Ann Mullally
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/9222fa08a4014b8e9549bfc479e67a9b
Autor:
Raquel P. Deering, Lili Blumenberg, Lianjie Li, Ankur Dhanik, Se Jeong, Stephane Pourpe, Hang Song, Lauren Boucher, Shoba Ragunathan, Yanxia Li, Maggie Zhong, Jessica Kuhnert, Christina Adler, Peter Hawkins, Namita T. Gupta, Michael Moore, Min Ni, Johanna Hansen, Yi Wei, Gavin Thurston
Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limited phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12db0afa4f8db9a275e19f65628eb7d3
https://doi.org/10.21203/rs.3.rs-2214010/v1
https://doi.org/10.21203/rs.3.rs-2214010/v1
Autor:
Matt Weinstock, Pavania Elavalakanar, Susan Bright, Srikanth R. Ambati, Jurriaan Brouwer‐Visser, Stephane Pourpe, Nathalie Fiaschi, Vladimir Jankovic, Gavin Thurston, Raquel P. Deering, Aafia Chaudhry, Robin Joyce, Jon Arnason
Publikováno v:
British journal of haematologyREFERENCES. 199(3)
Outcomes remain poor for patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL). While chimeric antigen receptor (CAR) T-cell therapy has revolutionised treatment, a significant proportion of patients relapse or fail to respond. Od
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974fa49fc9d8c7442fbf070f23a20c65
https://pubmed.ncbi.nlm.nih.gov/35892294
https://pubmed.ncbi.nlm.nih.gov/35892294
Autor:
Mathieu Gigoux, Morten O. Holmström, Roberta Zappasodi, Joseph J. Park, Stephane Pourpe, Cansu Cimen Bozkus, Levi M. B. Mangarin, David Redmond, Svena Verma, Sara Schad, Mariam M. George, Divya Venkatesh, Arnab Ghosh, David Hoyos, Zaki Molvi, Baransel Kamaz, Anna E. Marneth, William Duke, Matthew J. Leventhal, Max Jan, Vincent T. Ho, Gabriela S. Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R. Coleman Lindsley, Hans Hasselbalch, Jacob H. Grauslund, Thomas L. Lisle, Özcan Met, Patrick Wilkinson, Benjamin Greenbaum, Manuel A. Sepulveda, Timothy Chan, Raajit Rampal, Mads H. Andersen, Omar Abdel-Wahab, Nina Bhardwaj, Jedd D. Wolchok, Ann Mullally, Taha Merghoub
Publikováno v:
Science Translational Medicine. 14
The majority of JAK2V617F-negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin (CALR), resulting in a common carboxyl-terminal mutant fragment (CALRMUT), representing an attractive source of neoant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5ff55140f482ee33ec173cfebf6e6b
https://doi.org/10.1126/scitranslmed.aba4380
https://doi.org/10.1126/scitranslmed.aba4380
Autor:
Jeremy Tchaicha, Mathieu Gigoux, Alfredo C. Castro, Levi Mangarin, Luis Felipe Campesato, Taha Merghoub, Jedd D. Wolchok, Dmitriy Zamarin, Cailian Liu, Karen McGovern, Ivan J. Cohen, Sadna Budhu, Jill Cavanaugh, Stephane Pourpe, David Redmond, Roberta Zappasodi, Chien-Huan Weng, Mark G. Manfredi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The tryptophan metabolite L-Kynurenine (Kyn) interacts with the ligand-activated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d59e3ffc81c5620e9286906dd2ae745
http://link.springer.com/article/10.1038/s41467-020-17750-z
http://link.springer.com/article/10.1038/s41467-020-17750-z
Autor:
Chien-Huan Weng, Fadi Samaan, Sadna Budhu, Levi Mangarin, Sébastien Monette, Cailian Liu, Stephane Pourpe, Linda Hamadene, Hong Zhong, Xia Yang, David Schroder, Roberta Zappasodi, Pamela Holland, Jedd D. Wolchok, Taha Merghoub
Publikováno v:
Cancer Research. 82:6150-6150
Multiple suppressive mechanisms within the tumor microenvironment (TME) are capable of blunting anti-tumor T cell responses. These include engagement of inhibitory receptors expressed in tumor-associated, exhausted CD8 T cells, such as programmed cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb42bc2f050e653a9f5c82e7a4397073
https://doi.org/10.1158/1538-7445.am2022-6150
https://doi.org/10.1158/1538-7445.am2022-6150
Autor:
Srikanth R. Ambati, George D. Yancopoulos, Nathalie Fiaschi, Kamil J. Cygan, Se Jeong, Stephane Pourpe, Wen Zhang, Rajat Bannerji, Jurriaan Brouwer-Visser, Sara Hamon, Ranjana H. Advani, Gavin Thurston, Raquel Deering, Johannes Duell, Lauren Boucher, Aafia Chaudhry, Vladimir Jankovic, Dina M. Flink, Andrew J. Murphy, Andres Sirulnik, Ankur Dhanik, David M. Weinreich, Max S. Topp
Publikováno v:
Blood. 136:10-11
BACKGROUND: Odronextamab (REGN1979) is a first-in-class, hinge-stabilized, fully human CD20 x CD3 IgG4-based bispecific antibody that binds to CD20-expressing cells and CD3 on T cells, targeting CD20+ cells via T-cell-mediated cytotoxicity independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64a603cf26e7f149b73f2e543b4f07e
https://doi.org/10.1182/blood-2020-137499
https://doi.org/10.1182/blood-2020-137499
Autor:
Luis Felipe Campesato, Stephane Pourpe, Jedd D. Wolchok, Sadna Budhu, Taha Merghoub, Jeremy H. Tchaicha, Dmitriy Zamarin, Mathieu Gigoux, Mark Manfredi, Karen McGovern, Cailian Liu
Publikováno v:
Cancer Immunology Research. 8:PR05-PR05
Immune checkpoint blockade (ICB) has been shown to convey significant clinical activity across a spectrum of malignancies, yet there is now recognition that multiple mechanisms of resistance can impair response. The catabolism of tryptophan into meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f34f9d883fadf162361ceff9da2830
https://doi.org/10.1158/2326-6074.tumimm18-pr05
https://doi.org/10.1158/2326-6074.tumimm18-pr05