Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephane Perreault"'
Publikováno v:
Accounts of chemical research. 55(18)
ConspectusAtropisomerism is a type of axial chirality resulting from hindered rotation about a σ bond that gives rise to nonsuperimposable stereoisomers (termed "atropisomers"). The inversion of chirality of an atropisomeric axis is a time- and temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491de7847090a95d5be2c5055d3fa08b
https://pubmed.ncbi.nlm.nih.gov/36069734
https://pubmed.ncbi.nlm.nih.gov/36069734
Publikováno v:
Accounts of Chemical Research. 56:187-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d926369715e2b75c7effd196acd633
https://doi.org/10.1021/acs.accounts.2c00765
https://doi.org/10.1021/acs.accounts.2c00765
Autor:
Adrian Tomkinson, Gary Phillips, Jayaraman Chandrasekhar, Nicholas Alexander Till, Leena Patel, Jia Hao, Jennifer Treiberg, Joseph Therrien, Kathleen S. Keegan, Mary E. McGrath, Sedillo Kassandra F, Fatima Arjmand, Yelena Zherebina, Stephane Perreault, David Koditek, Clinton K. Matson, Eve-Irene Lepist
Publikováno v:
ACS Med Chem Lett
[Image: see text] A series of PI3Kβ selective inhibitors derived from a novel 4-(1H-benzo[d]imidazol-1-yl)quinoline chemotype has been rationally designed. Crucial to achieving the desired selectivity over the other class I PI3K isoforms, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141717e365da34c534fb82eddbca0b95
https://doi.org/10.1021/acsmedchemlett.0c00095
https://doi.org/10.1021/acsmedchemlett.0c00095
Autor:
Gary Phillips, Leena Patel, Stephane Perreault, Jennifer Treiberg, Nicholas Alexander Till, Eve-Irene Lepist, Armando G. Villaseñor, Mary E. McGrath, David Koditek, Yelena Zherebina, John R. Somoza, Sedillo Kassandra F, Joshua Van Veldhuizen, Joseph Therrien, Ryan Dick, Jayaraman Chandrasekhar
Publikováno v:
Journal of Medicinal Chemistry. 61:6858-6868
Atropisomerism is a type of axial chirality in which enantiomers or diastereoisomers arise due to hindered rotation around a bond axis. In this manuscript, we report a case in which torsional scan studies guided the thoughtful creation of a restricte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a7f21c3079be9796f9eb37ab9e739
https://doi.org/10.1021/acs.jmedchem.8b00797
https://doi.org/10.1021/acs.jmedchem.8b00797
Autor:
Gary Phillips, Nikolai Novikov, Kamal D. Puri, Mary E. McGrath, Leena Patel, Carmen Ip, Arthur Yeung, Latesh Lad, Kirk L. Stevens, Musong Kim, Eve-Irene Lepist, Armando G. Villaseñor, Jayaraman Chandrasekhar, Joseph Therrien, Joshua Kaplan, Jerry Evarts, John R. Somoza, Aaron C. Haran, David Koditek, Stephane Perreault, Bart H. Steiner, Jennifer Treiberg
Publikováno v:
Journal of Medicinal Chemistry. 59:3532-3548
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbe4b5b6b4c34240fb4472508c6868c
https://doi.org/10.1021/acs.jmedchem.6b00213
https://doi.org/10.1021/acs.jmedchem.6b00213
Autor:
Jerry Evarts, Gary Phillips, Joshua Kaplan, David Koditek, Kathleen S. Keegan, Adam Kashishian, Zhi-Hua Cui, Joseph Therrien, Jennifer Treiberg, Bart Phillips, Latesh Lad, Eve-Irene Lepist, Jayaraman Chandrasekhar, Leena Patel, Anella Yahiaoui, Stephane Perreault, Jia Hao, Mary E. McGrath, Thomas Kenney
Publikováno v:
Journal of medicinal chemistry. 60(4)
Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a2121eb475207997996dbaba211945
https://pubmed.ncbi.nlm.nih.gov/28106991
https://pubmed.ncbi.nlm.nih.gov/28106991
Autor:
Tomislav Rovis, Stephane Perreault
Publikováno v:
Synthesis. 45:719-728
An efficient approach to the tricyclic framework of FR901483 is described. The sequence features a [3,3]-sigmatropic rearrangement of a cyanate to an isocyanate, followed by its subsequent asymmetric rhodium-catalyzed [2+2+2] cycloaddition with a ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf6315cf85a4c580b9a9f34fcda7a61
https://doi.org/10.1055/s-0032-1316786
https://doi.org/10.1055/s-0032-1316786
Autor:
Kamal D. Puri, Carmen Ip, Adam Kashishian, Gary Phillips, Sandy Koppenol, Musong Kim, Jennifer Treiberg, Armando G. Villaseñor, Jayaraman Chandrasekhar, Stephane Perreault, Kristen Forseth, Leena Patel, Mary E. McGrath, Bart H. Steiner, Joseph Therrien, John R. Somoza, Aaron C. Haran, David Koditek, Latesh Lad, Eve-Irene Lepist, Jerry Evarts
Publikováno v:
Journal of medicinal chemistry. 59(19)
Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8830debbf42314c8fbf74c493372feca
https://pubmed.ncbi.nlm.nih.gov/27660855
https://pubmed.ncbi.nlm.nih.gov/27660855
Autor:
Melissa L. Pease, Tomislav Rovis, Mark Emil Oinen, Derek M. Dalton, Ernest E. Lee, Robert T. Yu, Stephane Perreault, Guillaume Malik, Kevin M. Oberg
Publikováno v:
Journal of the American Chemical Society. 131:15717-15728
This manuscript describes the development and scope of the asymmetric rhodium-catalyzed [2 + 2 + 2] cycloaddition of terminal alkynes and alkenyl isocyanates leading to the formation of indolizidine and quinolizidine scaffolds. The use of phosphorami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388d8ed9df136f7384d9306043276603
https://doi.org/10.1021/ja905065j
https://doi.org/10.1021/ja905065j
Autor:
Stéphane Perreault, Sylvie Pelletier
C'est auprès des personnes sourdes, malentendantes, sourdes-aveugles et des jeunes ayant une déficience du langage que l'Institut Raymond-Dewar réalise sa mission. Ce lieu d'expertise héritier de plus de 160 ans d'histoire prend racine dans les p
