Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephane Peluso"'
Autor:
Erika Hamilton, Dejan Juric, Nora Zizlsperger, Hatem Soliman, Charley Hubbard, Anthony Elias, Brenda C O'Connell, Donna Fitzgerald, Jeffrey L Kutok, Judith Varner, Robert Ilaria, Melody A Cobleigh, Kate H R Tkaczuk, Arielle Lee, Shaker Dakhil, Stephane Peluso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis particularly in the metastatic setting. Treatments with anti-programmed cell death protein-1/programmed death-ligand 1 (PD-L1) immune chec
Externí odkaz:
https://doaj.org/article/2aa14a51f927465e959e3d470136e48a
Autor:
Julian Adams, Caroline F. Ribeiro, Alfredo Csibi, Jeremy Tchaicha, Silvano Bosari, Benjamin Larimer, Giorgia Zadra, Scott M. Dehm, Lisa M. Butler, Stefano Cacciatore, Vito J. Palombella, Yeung Ho, Débora Campanella Bastos, Svitlana Tyekucheva, Clyde Bango, Paolo Chetta, Stephen R. Plymate, Stephane Peluso, Massimo Loda, Brian Lawney, Cornelia Photopoulos, Xueliang Gao, Sudeepa Syamala, Ying Huang, Leigh Ellis, Radha L. Kalekar, Umar Mahmood, Laura D’Anello, Takuma Uo, Jeffery L. Kutok, Colm Morrissey, Karen McGovern
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Standard of care for metastatic castration-resistant prostate cancer (mCRPC) mainly relies on suppression of androgen receptor (AR) signaling. This approach has no lasting benefit due to the emergence of resistance mechanisms, such as li
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Autor:
Virendar K. Kaushik, Prakash Raman, Ying Sun, Courtney Cullis, Ruth E. Gimeno, Effie Tozzo, Dong Yu Sun, Praveen Sanchetti, Hui Wu, Bing Guan, Tracy J. Jenkins, Peter J. Tummino, Thomas Daniels, Sandhya Punreddy, James Brown, Yingchun Ye, Christopher Blackburn, Stephen M. Condon, Brian K. Hubbard, Stephane Peluso, Suresh K. Balani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3504-3509
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group
Publikováno v:
Future oncology (London, England). 6(4)
Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis. Overexpression of FASN is common in many cancers, and accumulating evidence suggests that it is a metabolic oncogene with an important role in tumor growth and survival, m