Výsledky vyhledávání - "Stephane Leonce"

Synthesis and Biological Activity of Sulfonamide Derivatives of Epipodophyllotoxin

Autor: Daniel Dauzonne, Pierre Renard, Chawki Boukarim, Claude Monneret, Paola B. Arimondo, Stephane Leonce, Bruno Pfeiffer, Dominique Guianvarc'h, Laurence Kraus-Berthier, Maria Duca, Alain Pierré

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (9), pp.2365-2374
Journal of Medicinal Chemistry, 2004, 47 (9), pp.2365-2374

A series of novel 4beta-substituted sulfonamide derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin has been synthesized. Their effects on human DNA topoisomerase II and, in some cases, on tubulin polymerization were evaluated. Compounds 8a, 8c, 8f,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08301b7e9756f2ce18c940cdde883523
https://doi.org/10.1021/jm031117b

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Phenotypic and Functional Changes in Regenerated Porcine Coronary Endothelial Cells

Autor: Jean-Pierre Bidouard, Delphine Saboureau, Jean-Paul Vilaine, Paul M. Vanhoutte, Marie-Pierre Fournet-Bourguignon, Maria Castedo-Delrieu, Stephane Leonce, Isabelle Delescluse

Publikováno v: Circulation Research. 86:854-861

Abstract —Porcine coronary arteries with regenerated endothelium exhibit impaired endothelium-dependent relaxations. Experiments were designed to analyze the structural and functional changes occurring in regenerated endothelial cells. Primary cult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ee40bebe30f97af22227349cde8fc
https://doi.org/10.1161/01.res.86.8.854

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Synthesis and Biological Evaluation of Flavanones and Flavones Related to Podophyllotoxin

Autor: Claude Monneret, Daniel Dauzonne, Anne Gonzalez de Peredo, Stephane Leonce

Publikováno v: Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 1998, 46 (1), pp.79-83. ⟨10.1248/cpb.46.79⟩

A series of novel flavonoids comprising structural elements present in the antineoplastic agents podophyllotoxin and etoposide was synthesized. These oxygen-containing analogues of antiproliferative quinolones exhibited moderate cytotoxicity towards

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabb09f821418cfd0309caf2a4d4b65f
https://doi.org/10.1248/cpb.46.79

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Synthesis of Some 5′-Thiopentofuranosylpyrimidines as Potential Anti-tumor Agents

Autor: Stephane Leonce, Frédéric Girard, Luigi A. Agrofoglio

Publikováno v: Tetrahedron Letters. 38:7535-7538

The preparation of hitherto unknown, 2′,3′-didehydro-3′-deoxythymidine derived 5′-thioether, sulfoxide, sulfone [ 4–9 ] is described. The key steps of this synthesis are the nucleophilic displacements of a halogen by a thioalkyl sodium salt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6990be2f42d67a8c4530e4872e4cf09b
https://doi.org/10.1016/s0040-4039(97)10025-9

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Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines

Autor: Christelle Lamazzi, Gérald Guillaumet, Charles W. Rees, Bruno Pfeiffer, Stephane Leonce, Pierre Renard, Thierry Besson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:2183-2185

Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4.5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd5bcc59d87de2f8f59bcc145e4ddb1
https://doi.org/10.1016/s0960-894x(00)00427-3

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Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives

Autor: Stephane Leonce, Paola B. Arimondo, Claude Monneret, Dominique Guianvarc'h, Laurence Kraus-Berthier, Maria Duca, Alain Pierré, Daniel Dauzonne, Pierre Renard, Sylvie Thirot, Emmanuel Bertounesque, Philippe Meresse, Bruno Pfeiffer

Publikováno v: Journal of medicinal chemistry. 48(2)

Etoposide (VP-16) is a potent human DNA topoisomerase II poison, derived from 4'-demethylepipodophyllotoxin, widely used in cancer chemotherapy. Continuous efforts have driven to synthesize new related compounds, presenting decreased toxic side effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27b05e3824723b4dbfe2243948b49e
https://pubmed.ncbi.nlm.nih.gov/15658872

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Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III

Autor: Hadjila, Chabane, Christelle, Lamazzi, Valerie, Thiery, Alain, Pierre, Stephane, Leonce, Bruno, Pfeiffer, Pierre, Renard, Gérald, Guillaumet, Thierry, Besson

Publikováno v: Journal of enzyme inhibition and medicinal chemistry. 18(2)

Novel thiazolocarbazole derivatives have been synthesized via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor activity of these polyheterocyclic compounds was studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74da1c33df076388111e841e00691e63
https://pubmed.ncbi.nlm.nih.gov/12943201

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Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL

Autor: Marie-Pierre Fournet-Bourguignon, Maria Castedo-Delrieu, Jean-Paul Vilaine, Cyril Briant, Stephane Leonce, Christine Breugnot, Hélène Reure, Paul M. Vanhoutte, Ludovic Lesage, Simon Kennedy

Publikováno v: Journal of vascular research. 40(4)

Increased accumulation of lipoproteins and cholesterol within cells from regenerated endothelium may be responsible for their reported dysfunction. This study compared the presence and uptake of oxidized forms of low-density lipoprotein (LDL) in cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42035a85549709dfe32bbcbe40a5f350
https://pubmed.ncbi.nlm.nih.gov/12904688

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ChemInform Abstract: Expeditious Synthesis and Cytotoxic Activity of New Cyanoindolo[3,2-c]quinolines and Benzimidazo[1,2-c]quinazolines

Autor: Stephane Leonce, Gérald Guillaumet, Pierre Renard, Thierry Besson, Christelle Lamazzi, Bruno Pfeiffer, Charles W. Rees

Publikováno v: ChemInform. 31

Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4,5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::590a2f8e0e5a18cd725ce23d7a8138fd
https://doi.org/10.1002/chin.200052135

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