Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Stephane Lefrancois"'
Autor:
William D. Kim, Morgan L. D. M. Wilson-Smillie, Aruban Thanabalasingam, Stephane Lefrancois, Susan L. Cotman, Robert J. Huber
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At least a dozen NCL subtypes have been identified that are each li
Externí odkaz:
https://doaj.org/article/69177886e3e149318f5e1cda68a724f5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract AP-1 is a clathrin adaptor recruited to the trans-Golgi Network where it can interact with specific signals found in the cytosolic tail of cargo proteins to incorporate them into clathrin-coated vesicles for trafficking. The small G protein
Externí odkaz:
https://doaj.org/article/5c25b839927c4dc981e9a61bf3574f94
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 9, Pp 1593-1603 (1999)
Prosaposin is the precursor of four lysosomal saposins that promote the degradation of glycosphingolipids (GSLs) by acidic hydrolases. GSLs contain a hydrophobic ceramide moiety, which acts as a membrane anchor, and a hydrophilic oligosaccharide chai
Externí odkaz:
https://doaj.org/article/004f6c895160446db72870c891356554
Publikováno v:
Biochemical Journal. 478:2339-2357
CLN5 is a soluble endolysosomal protein whose function is poorly understood. Mutations in this protein cause a rare neurodegenerative disease, Neuronal Ceroid Lipofuscinosis. We previously found that depletion of CLN5 leads to dysfunctional retromer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e3047c7f87c4d15688e90f1a73469
https://doi.org/10.1042/bcj20210171
https://doi.org/10.1042/bcj20210171
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Christopher J. Minnis, Sara E. Mole, Tatyana Shelkovnikova, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
Publikováno v:
Journal of Biological Chemistry. 299:104649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ebac2b96625591a4a42035c785b922
https://doi.org/10.1016/j.jbc.2023.104649
https://doi.org/10.1016/j.jbc.2023.104649
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
The assembly of membrane-less organelles such as stress granules (SGs) is emerging as central in helping cells rapidly respond and adapt to stress. Following stress sensing, the resulting global translational shutoff leads to the condensation of stal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed33682083daa19d7d22202b97fee15
https://doi.org/10.1101/2022.05.20.492784
https://doi.org/10.1101/2022.05.20.492784
Publikováno v:
Bioscience Reports. 42
Lysosomes are key regulators of many fundamental cellular processes such as metabolism, autophagy, immune response, cell signalling and plasma membrane repair. These highly dynamic organelles are composed of various membrane and soluble proteins, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e39a9189adad371804cc436a0c96afd
https://doi.org/10.1042/bsr20211856
https://doi.org/10.1042/bsr20211856
Autor:
Etienne Sauvageau, Stephane Lefrancois
Publikováno v:
The Biochemist. 41:36-40
The Beginner's Guides are an ongoing series of articles in the magazine, each one covering a key technique and offering the scientifically literate but not necessarily expert audience a background briefing on the underlying science of a technique tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d05b793d3f31c8280449cada650cf7c
https://doi.org/10.1042/bio04106036
https://doi.org/10.1042/bio04106036
Autor:
William D. Kim, Morgan L. D. M. Wilson-Smillie, Aruban Thanabalasingam, Stephane Lefrancois, Susan L. Cotman, Robert J. Huber
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At least a dozen NCL subtypes have been identified that are each li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be69b61ab5133743079f101425db72d
https://pubmed.ncbi.nlm.nih.gov/35252181
https://pubmed.ncbi.nlm.nih.gov/35252181