Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Stephane L. Bourque"'
Autor:
Yana Kibalnyk, Elia Afanasiev, Ronan M. N. Noble, Adrianne E. S. Watson, Irina Poverennaya, Nicole L. Dittmann, Maria Alexiou, Kara Goodkey, Amanda A. Greenwell, John R. Ussher, Igor Adameyko, James Massey, Daniel Graf, Stephane L. Bourque, Jo Anne Stratton, Anastassia Voronova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract ANKRD11 (Ankyrin Repeat Domain 11) is a chromatin regulator and a causative gene for KBG syndrome, a rare developmental disorder characterized by multiple organ abnormalities, including cardiac defects. However, the role of ANKRD11 in heart
Externí odkaz:
https://doaj.org/article/ce8c90516c504572ba5ad45d0a89daf1
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Autor:
MengQi Zhang, Dean A. Fergusson, Rahul Sharma, Ciel Khoo, Asher A. Mendelson, Braedon McDonald, Kimberly F. Macala, Neha Sharma, Sean E. Gill, Kirsten M. Fiest, Christian Lehmann, Risa Shorr, Forough Jahandideh, Stephane L. Bourque, Patricia C. Liaw, Alison Fox-Robichaud, Manoj M. Lalu, on behalf of the Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Background The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational st
Externí odkaz:
https://doaj.org/article/19f1ce8a2d3b487d9eec9135366362f3
Publikováno v:
Food Chemistry: X, Vol 13, Iss , Pp 100222- (2022)
Diabetes mellitus, a group of metabolic disorders characterized by persistent hyperglycemia, affects millions of people worldwide and is on the rise. Dietary proteins, from a wide range of food sources, are rich in bioactive peptides with antidiabeti
Externí odkaz:
https://doaj.org/article/fad71e5326ec427180484baacc207bc7
Autor:
Andrew J. Forgie, Kelsea M. Drall, Stephane L. Bourque, Catherine J. Field, Anita L. Kozyrskyj, Benjamin P. Willing
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Early-life malnutrition may have long-lasting effects on microbe-host interactions that affect health and disease susceptibility later in life. Diet quality and quantity in conjunction with toxin and pathogen exposure are key cont
Externí odkaz:
https://doaj.org/article/3499ab4be36143f28a46e122ba26d260
Autor:
Saad Y. Salim, Nour AlMalki, Kimberly F. Macala, Alyssa Wiedemeyer, Thomas F. Mueller, Thomas A. Churchill, Stephane L. Bourque, Rachel G. Khadaroo
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 483 (2023)
Sepsis remains one of the leading causes of death worldwide. Oncostatin M (OSM), an interleukin (IL)-6 family cytokine, can be found at high levels in septic patients. However, little is known about its role in sepsis. This study aimed to determine i
Externí odkaz:
https://doaj.org/article/9e6ec6197c06438bb0d4a755e66efbd6
Autor:
MengQi Zhang, BSc, Joshua Montroy, MSc, Rahul Sharma, HBSc, Dean A. Fergusson, MHA, PhD, Asher A. Mendelson, MD, PhD, FRCPC, Kimberly F. Macala, MD, FRCPC, Stephane L. Bourque, PhD, Jared M. Schlechte, BSc, Mikaela K. Eng, MSc, Braedon McDonald, MD, PhD, FRCPC, Sean E. Gill, PhD, Kirsten M. Fiest, PhD, Patricia C. Liaw, MSc, PhD, Alison Fox-Robichaud, MSc, MD, FRCPC, Manoj M. Lalu, MD, PhD, FRCPC, on behalf of the Canadian Critical Care Translational Biology Group and the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Critical Care Explorations, Vol 3, Iss 6, p e0433 (2021)
OBJECTIVES:. Preclinical studies provide an opportunity to evaluate the relationship between sex and sepsis, and investigate underlying mechanisms in a controlled experimental environment. The objective of our systematic review was to assess the impa
Externí odkaz:
https://doaj.org/article/3d91592aef26469088861c5e8ddfd0d5
Autor:
Adrianna J. Woolsey, Jalal A. Nanji, Chantal Moreau, Sudhakar Sivapalan, Stephane L. Bourque, Alfonso Ceccherini-Nelli, Ferrante S. Gragasin
Publikováno v:
Brazilian Journal of Psychiatry (2021)
Objective: Electroconvulsive therapy (ECT) is a well-established therapeutic intervention for major depressive disorder. Recent literature has shown that the anesthetic agent ketamine has some antidepressant properties at low doses and may be an alte
Externí odkaz:
https://doaj.org/article/ba04001be1064cb688531a25390af727
Autor:
Omolara B. Sanni, Thane Chambers, Jia Hang Li, Stewart Rowe, Andrew G. Woodman, Maria B. Ospina, Stephane L. Bourque
Publikováno v:
EClinicalMedicine, Vol 27, Iss , Pp 100555- (2020)
Background: Iron deficiency (ID) is the leading single-nutrient deficiency in the world. Anaemia is a common outcome of ID that affects half of pregnancies worldwide with serious consequences for child development. Whether haematologic indices and bi
Externí odkaz:
https://doaj.org/article/00d32ef79b2848d2a0b4295a41e20a76
Autor:
Forough Jahandideh, Sareh Panahi, Ronan M. N. Noble, Ferrante S. Gragasin, Rachel G. Khadaroo, Kimberly F. Macala, Stephane L. Bourque
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 470 (2022)
Sepsis is associated with circulatory dysfunction contributing to disturbed blood flow and organ injury. Decreased organ perfusion in sepsis is attributed, in part, to the loss of vasoregulatory mechanisms. Identifying which vascular beds are most su
Externí odkaz:
https://doaj.org/article/e1fbcfcb9fa64a209cc5478af76eb0e5