Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Autor: Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units. A multi

Externí odkaz: https://doaj.org/article/9680bc4f067244f5859525deb060514b

Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species

Autor: Simone Esposito, Alain Krick, Olivier Pasquier, Fabrice Bonche, Raffaele Ingenito, Paola Magotti, Elisabetta Bianchi, Edith Monteagudo, Mariana Gallo, Daniel Oscar Cicero, Laura Orsatti, Maria Veneziano, Fulvia Caretti, Riccardo Mele, Daniela Roversi, Nadia Gennari, Denis Brasseur, Laurence Gauzy-Lazo, Olivier Duclos, Christine Mauriac, Stephane Illiano, Sergio Mallart

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, 2023, 227, pp.115256. ⟨10.1016/j.jpba.2023.115256⟩

International audience; We recently described C18 fatty acid acylated peptides as a new class of potent long-lasting single-chain RXFP1 agonists that displayed relaxin-like activities in vivo. Early pharmacokinetics and toxicological studies of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe48f7e018f9c4ba38832ba51bf5e8f5
https://hdl.handle.net/2108/313607

microRNA blood signature for localized radiation injury

Autor: Lucie Ancel, Olivier Gabillot, Chloé Szurewsky, Romain Granger, Amandine Sache, Frédéric Voyer, Gaëtan Gruel, Stéphane Illiano, Marc Benderitter, Bernard Le Guen, Maâmar Souidi, Mohamed Amine Benadjaoud, Stéphane Flamant

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract A radiological accident, whether from industrial, medical, or malicious origin, may result in localized exposure to high doses of ionizing radiations, leading to the development of local radiation injury (LRI), that may evolve toward deep ul

Externí odkaz: https://doaj.org/article/95b6b1b3eb054219ab9215540f423b78

Bradykinin-induced contractions of canine saphenous veins: mediation by B2 receptors and involvement of eicosanoids

Autor: Robert Marsault, Stephane Illiano, Paul M. Vanhoutte

Publikováno v: British Journal of Pharmacology. 120:215-220

1. Experiments were designed to determine the subtype of kinin-receptors mediating the contraction of venous smooth muscle to bradykinin and to investigate the involvement of metabolites of arachidonic acid in this response. 2. Bradykinin (10(-9) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cfefa8f3b98fe036ac37dce137e6264
https://doi.org/10.1038/sj.bjp.0700898

Potentiation by Trandolaprilat of the Endothelium-Dependent Hyperpolarization Induced by Bradykinin

Autor: Stephane Illiano, Jean Vivien Mombouli, Tetsuhiko Nagao, Paul M. Vanhoutte

Publikováno v: Journal of Cardiovascular Pharmacology. 23:S6-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3595e228013ca2c962d6f0d1b1d5501b
https://doi.org/10.1097/00005344-199406001-00003