Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Stephane Houel"'
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Akademický článek
Identification of a Family of Fatty-Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties
Autor: Jun Long, Robert Tokhunts, William M. Old, Stephane Houel, Jezabel Rodgriguez-Blanco, Samer Singh, Neal Schilling, Anthony J. Capobianco, Natalie G. Ahn, David J. Robbins
Publikováno v: Cell Reports, Vol 10, Iss 8, Pp 1280-1287 (2015)
Hedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpressed.
Externí odkaz: https://doaj.org/article/7c4caa41bf6f4a04bcca457b9eddf397
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3
A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry
Autor: Jonathan L. Josephs, Steve Hessmann, Penelope M. Drake, Stéphane Erb, Alain Beck, Stephane Houel, Sarah Cianférani, Romain Huguet, Oscar Hernandez-Alba, David Rabuka
Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2019, 30 (11), ⟨10.1007/s13361-019-02296-2⟩
International audience; Middle-down mass spectrometry (MD MS) has emerged as a promising alternative to classical bottom-up approaches for protein characterization. Middle-level experiments after enzymatic digestion are routinely used for subunit ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326a3fd8dae4b57d9019f999dec97ab7
https://pubmed.ncbi.nlm.nih.gov/31429052
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4
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Autor: Thomas Lee, Nan Wang, Stephane Houel, Natalie G. Ahn, Scott A. Stuart, William M. Old
Publikováno v: Molecular & Cellular Proteomics. 14:1599-1615
Inhibitors of oncogenic B-RAF(V600E) and MKK1/2 have yielded remarkable responses in B-RAF(V600E)-positive melanoma patients. However, the efficacy of these inhibitors is limited by the inevitable onset of resistance. Despite the fact that these inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bace826f10dedd30d163def83cb5e2a
https://doi.org/10.1074/mcp.m114.047233
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5
Identification of a Family of Fatty-Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties
Autor: Neal S. Schilling, Anthony J. Capobianco, Stephane Houel, William M. Old, Samer Singh, Natalie G. Ahn, Jun Long, Robert Tokhunts, Jezabel Rodgriguez-Blanco, David J. Robbins
Publikováno v: Cell Reports, Vol 10, Iss 8, Pp 1280-1287 (2015)
SummaryHedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a757ec48cb2eb0bb1f103089fa8e086
http://www.sciencedirect.com/science/article/pii/S221112471500100X
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6
Dosage and Temporal Thresholds in microRNA Proteomics*
Autor: Nan Wang, Natalie G. Ahn, Stephane Houel, William M. Old, Kasey L. Couts, Thomas Lee
Publikováno v: Molecular & Cellular Proteomics. 14:289-302
MicroRNAs (miRNAs) modulate protein and mRNA expression through translational repression and/or mRNA decay. In this study, we combined SILAC-based proteomics and RNAseq to identify primary targets based on measurements of protein and mRNA repression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59cde198ca5c22bbf59cd5d8bf6d1d2
https://doi.org/10.1074/mcp.m114.043851
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7
The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor
Autor: Hui Wei, Paul E. Morin, Dianlin Xie, Li Tao, Joomi Ahn, John R. Engen, Guodong Chen, Jingjie Mo, Zheng Lin, Daniel Cohen, Roxana E. Iacob, Adrienne A. Tymiak, Stephane Houel, Michael L. Doyle
Publikováno v: Journal of the American Society for Mass Spectrometry. 25:2093-2102
The precise and unambiguous elucidation and characterization of interactions between a high affinity recognition entity and its cognate protein provides important insights for the design and development of drugs with optimized properties and efficacy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5746dfde5c58eab6f910a735a52bff52
https://doi.org/10.1007/s13361-014-0973-1
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8
Characterisation of glycoproteins using a quadrupole time-of-flight mass spectrometer configured for electron transfer dissociation
Autor: Johannes P. C. Vissers, Ying Qing Yu, Martin De Cecco, Asish B. Chakraborty, Steven Derek Pringle, Jonathan P. Williams, Stephane Houel, Lee A. Gethings, Keith Richardson, Jeffery Mark Brown, Weibin Chen
Publikováno v: Rapid Communications in Mass Spectrometry. 27:2383-2390
RATIONALE Electron transfer dissociation (ETD) within ion trapping mass spectrometers has proven to be a useful tool for the characterisation of post-translational modifications. In this study, we describe the implementation of ETD upon a modified qu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064f5d5f5afbff8ac9781758a79241c3
https://doi.org/10.1002/rcm.6684
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9
The Non-Coding B2 RNA Binds to the DNA Cleft and Active-Site Region of RNA Polymerase II
Autor: Natalie G. Ahn, William M. Old, Steven L. Ponicsan, James A. Goodrich, Jennifer F. Kugel, Stephane Houel
Publikováno v: Journal of Molecular Biology. 425:3625-3638
The B2 family of short interspersed elements is transcribed into non-coding RNA by RNA polymerase III. The ~180-nt B2 RNA has been shown to potently repress mRNA transcription by binding tightly to RNA polymerase II (Pol II) and assembling with it in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64479f2e0d741eb9fec36b712fae83d
https://doi.org/10.1016/j.jmb.2013.01.035
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10
Quantitative functions of Argonaute proteins in mammalian development
Autor: Natalie G. Ahn, Evan O’Loughlin, Dónal O'Carroll, Dongmei Wang, Rui Yi, Zhaojie Zhang, Alexander Tarakhovsky, Thomas Lee, Stephane Houel
Publikováno v: Genes & Development. 26:693-704
Argonaute proteins (Ago1–4) are essential components of the microRNA-induced silencing complex and play important roles in both microRNA biogenesis and function. Although Ago2 is the only one with the slicer activity, it is not clear whether the sl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a97a228540fb7e567de1144a25f7b92
https://doi.org/10.1101/gad.182758.111
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