Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Stephane Gesta"'
Autor:
Tulin Dadali, Anne R. Diers, Shiva Kazerounian, Senthil K. Muthuswamy, Pallavi Awate, Ryan Ng, Saie Mogre, Carrie Spencer, Katerina Krumova, Hannah E. Rockwell, Justice McDaniel, Emily Y. Chen, Fei Gao, Karl T. Diedrich, Vijetha Vemulapalli, Leonardo O. Rodrigues, Viatcheslav R. Akmaev, Khampaseuth Thapa, Manuel Hidalgo, Arindam Bose, Vivek K. Vishnudas, A. James Moser, Elder Granger, Michael A. Kiebish, Stephane Gesta, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effec
Externí odkaz:
https://doaj.org/article/e79d9a1528004582b599d5a67e27bffe
Autor:
Jiaxin Sun, Chirag B. Patel, Taichang Jang, Milton Merchant, Chen Chen, Shiva Kazerounian, Anne R. Diers, Michael A. Kiebish, Vivek K. Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R. Narain, Seema Nagpal, Lawrence Recht
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selecti
Externí odkaz:
https://doaj.org/article/f351ed5583a042e9aacf892af8e97331
Autor:
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractThe spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the spindle checkpoint results in inhibit
Externí odkaz:
https://doaj.org/article/925891e8da284d118b898b3fe1cf5c4a
Autor:
Nicole E. Pellegrino, Arcan Guven, Kayleigh Gray, Punit Shah, Gargi Kasture, Maria-Dorothea Nastke, Anjan Thakurta, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Michael A. Kiebish
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3480 (2022)
Post-translational modifications of proteins ensure optimized cellular processes, including proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced homeostatic state. Abnormal post-translational modifications ar
Externí odkaz:
https://doaj.org/article/4d8bc6ebb90a402c92df82026f8d83ed
Autor:
Khampaseuth Thapa, Kai Connie Wu, Aishwarya Sarma, Eric M. Grund, Angela Szeto, Armando J. Mendez, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key
Externí odkaz:
https://doaj.org/article/56b449c48fb14bcc80a8f66ce09979f5
Autor:
Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J. Mendez, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain
Publikováno v:
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insuli
Externí odkaz:
https://doaj.org/article/d75f9c8e8cd84ed48bbe767a8e883d40
Autor:
Jialiang Yang, Jacob Hagen, Kalyani V. Guntur, Kimaada Allette, Sarah Schuyler, Jyoti Ranjan, Francesca Petralia, Stephane Gesta, Robert Sebra, Milind Mahajan, Bin Zhang, Jun Zhu, Sander Houten, Andrew Kasarskis, Vivek K. Vishnudas, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain, Eric E. Schadt, Carmen A. Argmann, Zhidong Tu
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only
Externí odkaz:
https://doaj.org/article/0c940c9ca1524a2aba2cc141c228b9cc
Autor:
Michael A. Kiebish, Punit Shah, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Stephane Gesta, Poornima K. Tekumalla, Chas Bountra, Elder Granger, Eric Schadt, Leonardo O. Rodrigues, Niven R. Narain
Publikováno v:
Applied Sciences, Vol 11, Iss 6, p 2466 (2021)
The emergence of COVID-19 progressed into a global pandemic that has functionally put the world at a standstill and catapulted major healthcare systems into an overburdened state. The dire need for therapeutic strategies to mitigate and successfully
Externí odkaz:
https://doaj.org/article/7476e5f3f1f842eeab9563018faaa469
Autor:
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptiona
Externí odkaz:
https://doaj.org/article/4440b470a131444c8abf9b4b553092fa
Autor:
Stephane Gesta, Jennifer A. Benanti, Niven R. Narain, Heather E. Arsenault, Anne R. Diers, Cassandra M. Leech, Julie M Ghizzoni, Vivek K. Vishnudas, Rangaprasad Sarangarajan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the spindle checkpoint results in inhibition of t