Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Stephane Flibotte"'
Autor:
Angela R. Wild, Peter W. Hogg, Stephane Flibotte, Shruti Kochhar, Rocio B. Hollman, Kurt Haas, Shernaz X. Bamji
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions of substrate proteins. Dysregulated S-palmitoylation is associated with a multitude of hum
Externí odkaz:
https://doaj.org/article/a543b3e8d1ab4d8ebc16a3a33ab99328
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Janel L. Kopp
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial neop
Externí odkaz:
https://doaj.org/article/ff9b541c39684bccacb601c1a9c7f635
Autor:
Su Wang, Victor-Felix Mautner, Ralph Buchert, Stephane Flibotte, Per Suppa, Jan M. Friedman, Manraj K. S. Heran
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Objective Neurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most reported studies of brain morphology in NF1 patients have included only children, and clinical implications o
Externí odkaz:
https://doaj.org/article/c521ff73b5e347c99e88f023201c6bbe
Autor:
Angela R Wild, Peter W Hogg, Stephane Flibotte, Glory G Nasseri, Rocio B Hollman, Danya Abazari, Kurt Haas, Shernaz X Bamji
Publikováno v:
eLife, Vol 11 (2022)
Protein S-palmitoylation is a reversible post-translational lipid modification that plays a critical role in neuronal development and plasticity, while dysregulated S-palmitoylation underlies a number of severe neurological disorders. Dynamic S-palmi
Externí odkaz:
https://doaj.org/article/6b927eeea5c84df5886b6c5e217e81c2
Autor:
Erica Li-Leger, Richard Feichtinger, Stephane Flibotte, Heinke Holzkamp, Ralf Schnabel, Donald G Moerman
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractIt has been estimated that 15%–30% of the ∼20,000 genes in C. elegansC. elegans
Externí odkaz:
https://doaj.org/article/0fe2d2f1a70344fb93591fd6fb0a6875
Autor:
Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Carla Zimmerman, Kunho Choi, Stephane Flibotte, Michel Roberge
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001221 (2021)
Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhi
Externí odkaz:
https://doaj.org/article/6c867feb7e4246c7815da789e71e9712
Autor:
Vinci Au, Erica Li-Leger, Greta Raymant, Stephane Flibotte, George Chen, Kiana Martin, Lisa Fernando, Claudia Doell, Federico I. Rosell, Su Wang, Mark L. Edgley, Ann E. Rougvie, Harald Hutter, Donald G. Moerman
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 135-144 (2019)
The Caenorhabditis elegans Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date, approximately 15,000 ORFs have associated putative null alleles. As ther
Externí odkaz:
https://doaj.org/article/38f38c20093b4e3ab2a414f3efc28908
Autor:
Anthony JE Berndt, Katerina M Othonos, Tianshun Lian, Stephane Flibotte, Mo Miao, Shamsuddin A Bhuiyan, Raymond Y Cho, Justin S Fong, Seo Am Hur, Paul Pavlidis, Douglas W Allan
Publikováno v:
eLife, Vol 9 (2020)
Retrograde BMP signaling and canonical pMad/Medea-mediated transcription regulate diverse target genes across subsets of Drosophila efferent neurons, to differentiate neuropeptidergic neurons and promote motor neuron terminal maturation. How a common
Externí odkaz:
https://doaj.org/article/f4c3b6d00d094fe39e611f3c10a9e2d6
Autor:
Karanjit Puri, Nathaniel Lal, Rui Shang, Sanjoy Ghosh, Stephane Flibotte, Roger Dyer, Bahira Hussein, Brian Rodrigues
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)
Background Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in insulin impacts the source of FA used by cardiomyocytes and the cardiac adaptations requir
Externí odkaz:
https://doaj.org/article/32545a18a0ff4c66b09065c54f869158