Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephane Erb"'
Autor:
Tony Rady, Victor Lehot, Julien Most, Stephane Erb, Sarah Cianferani, Guilhem Chaubet, Nicolas Basse, Alain Wagner
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103329- (2024)
Summary: Antibody-oligonucleotide conjugates (AOCs) are a fast-expanding modality for targeted delivery of therapeutic oligonucleotides to tissues. Here, we present a protocol to generate, purify, and analyze AOCs from off-the-shelf antibodies. We de
Externí odkaz:
https://doaj.org/article/14184fb4b07c49f2ad62182968eea0c3
Autor:
Pierre Coliat, Stéphane Erb, Hélène Diemer, Dan Karouby, Tristan Martin, Mainak Banerjee, Chen Zhu, Martin Demarchi, Sarah Cianférani, Alexandre Detappe, Xavier Pivot
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Pneumatic transportation systems (PTS) were recently proposed as a method to carry ready-for-injection diluted monoclonal antibodies (mAbs) from the pharmacy to the bedside of patients. This method reduces transportation time and improves th
Externí odkaz:
https://doaj.org/article/2c401a85c3e245a286d2afcfc12de327
Autor:
Tony Rady, Stéphane Erb, Safia Deddouche-Grass, Renaud Morales, Guilhem Chaubet, Sarah Cianférani, Nicolas Basse, Alain Wagner
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109068- (2024)
Summary: Double-stranded RNAs (dsRNA)-based strategies appeared as promising therapies to induce an inflammation in the tumor microenvironment. However, currently described systems generally lack active targeting of tissues, and their clinical transl
Externí odkaz:
https://doaj.org/article/10ee33c87c4e491baeca79edaa602a6d
Autor:
Victor Lehot, Ondřej Lidický, Julien Most, Stéphane Erb, Igor Dovgan, Artem Osypenko, Oleksandr Koniev, Sergii Kolodych, Lenka Kotrchová, Guilhem Chaubet, Sarah Cianférani, Tomáš Etrych, Alain Wagner
Publikováno v:
ACS Omega, Vol 8, Iss 43, Pp 40508-40516 (2023)
Externí odkaz:
https://doaj.org/article/61547958d4c8422b851129ddc858ab8c
Autor:
Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet, Isabelle M. L. Billas
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from funct
Externí odkaz:
https://doaj.org/article/a92389b629514a4e8a6968a1a1cd396d
Autor:
Victor Lehot, Patrick Neuberg, Manon Ripoll, François Daubeuf, Stéphane Erb, Igor Dovgan, Sylvain Ursuegui, Sarah Cianférani, Antoine Kichler, Guilhem Chaubet, Alain Wagner
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1643 (2023)
Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is of
Externí odkaz:
https://doaj.org/article/3b1c23f633864d7a9b898ed3a61b0eff
Autor:
Victor Lehot, Isabelle Kuhn, Marc Nothisen, Stéphane Erb, Sergii Kolodych, Sarah Cianférani, Guilhem Chaubet, Alain Wagner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. While the impact of dye and drug conjugation on antibodies’ ability to bind
Externí odkaz:
https://doaj.org/article/a5fbede99bbf44099b9275daa73200ad
Autor:
Evolène Deslignière, Hélène Diemer, Stéphane Erb, Pierre Coliat, Xavier Pivot, Alexandre Detappe, Oscar Hernandez-Alba, Sarah Cianférani
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 10, p 290 (2022)
Background: Native mass spectrometry (nMS) approaches appear attractive to complement bottom-up strategies traditionally used in biopharmaceutical industries thanks to their quite straightforward and rapid workflows, especially through online hyphena
Externí odkaz:
https://doaj.org/article/2eb3b84cdb244237b1b7bfa03505ee71
Autor:
Brice Beinsteiner, Gabriel V Markov, Stéphane Erb, Yassmine Chebaro, Alastair G McEwen, Sarah Cianférani, Vincent Laudet, Dino Moras, Isabelle M L Billas
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009492 (2021)
Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear receptors fu
Externí odkaz:
https://doaj.org/article/48e697a2f52f4e94a579272af3d6c135
Autor:
Mercè Farràs, Joan Miret, Marc Camps, Ramón Román, Óscar Martínez, Xavier Pujol, Stéphane Erb, Anthony Ehkirch, Sarah Cianferani, Antoni Casablancas, Jordi Joan Cairó
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining ho
Externí odkaz:
https://doaj.org/article/fed4e5c32d0c4f24a14729d42cf85902