Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephane Budel"'
Autor:
Tammy Szu-Yu Ho, Eric A. Huebner, Nick Andrews, Luis M. Pereira, Takao Omura, Lee Barrett, Stephen M. Strittmatter, Zhaoxin Jiang, Clifford J. Woolf, Stephane Budel, Bhagat Singh, Janie Merkel, Michael Costigan, Kush Kapur, Xingxing Wang
Publikováno v:
Mol Neurobiol
Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d6ea499f645587272c2f7a07b9c2a2
https://doi.org/10.1007/s12035-018-1349-5
https://doi.org/10.1007/s12035-018-1349-5
Autor:
Kang-Ho Song, Stephane Budel, Xingxing Wang, Grahame Gould, Stephen M. Strittmatter, Kenneth W. Baughman
Publikováno v:
Journal of Neurotrauma. 26:81-95
The GTP-binding protein RhoA regulates microfilament dynamics in many cell types and mediates the inhibition of axonal regeneration by myelin and chondroitin sulfate proteoglycans. Unlike most other nonsteroidal anti-inflammatory drugs, ibuprofen sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497346df3d590424b9a0c9e5a709273c
https://doi.org/10.1089/neu.2007.0464
https://doi.org/10.1089/neu.2007.0464
Autor:
Amy F.T. Arnsten, Ji Liao, Althea A. Stillman, Fuki M. Hisama, Samuel G. B. Johnson, James H. Park, Betty P. Liu, Aaron W. McGee, Stephane Budel, Stefano Sodi, Bao-Zhu Yang, Thihan Padukkavidana, Zeny Feng, Jieun Kim, Fenghua Hu, Juha Lauren, Joel Gelernter, Hongyu Zhao, Stephen M. Strittmatter
Publikováno v:
The Journal of Neuroscience. 28:13161-13172
In schizophrenia, genetic predisposition has been linked to chromosome 22q11 and myelin-specific genes are misexpressed in schizophrenia. Nogo-66 receptor 1 (NGRorRTN4R) has been considered to be a 22q11 candidate gene for schizophrenia susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02071b1803da2b18b9f61c485f66768
https://doi.org/10.1523/jneurosci.3828-08.2008
https://doi.org/10.1523/jneurosci.3828-08.2008
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 361:1593-1610
Robust axonal growth is required during development to establish neuronal connectivity. However, stable fibre patterns are necessary to maintain adult mammalian central nervous system (CNS) function. After adult CNS injury, factors that maintain axon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25f76e2f952a503e718cb92e495af6e
https://doi.org/10.1098/rstb.2006.1891
https://doi.org/10.1098/rstb.2006.1891
Publikováno v:
Circulation Research. 93:61-68
We investigated roles for homocellular (endothelium or smooth muscle) and heterocellular (myoendothelial) conduction pathways along hamster cheek pouch arterioles in vivo (n=64; diameter, 33+/-1 microm). Endothelium-dependent and -independent vasoact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce8a3e443aa04e28ac6a2d10020a935
https://doi.org/10.1161/01.res.0000080318.81205.fd
https://doi.org/10.1161/01.res.0000080318.81205.fd
Autor:
Stephane Budel, Sang ohk Shim, Zeny Feng, Hongyu Zhao, Fuki M. Hisama, Stephen M. Strittmatter
Publikováno v:
Schizophrenia research. 99(1-3)
Letter to the Editors: Multiple genetic, environmental and developmental factors have been implicated (Hyman, 1999; Riley et al., 2000) in the etiology of schizophrenia. Axon guidance molecules may be considered candidate genes to explain an early de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f58c592886b03f3aebbfc324ddb9f8a
https://pubmed.ncbi.nlm.nih.gov/18096369
https://pubmed.ncbi.nlm.nih.gov/18096369
Autor:
Stephane Budel, R. Blake Pepinsky, Jane K. Relton, Stephen M. Strittmatter, Lee Walus, Thomas Engber, Benxiu Ji, Mingwei Li
Publikováno v:
The European journal of neuroscience. 22(3)
Methylprednisolone (MP) is a synthetic glucocorticoid used for the treatment of spinal cord injury (SCI). Soluble Nogo-66 receptor (NgR) ectodomain is a novel experimental therapy for SCI that promotes axonal regeneration by blocking the growth inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c556712a143fd8f328c2a3cbb75e6e03
https://pubmed.ncbi.nlm.nih.gov/16101740
https://pubmed.ncbi.nlm.nih.gov/16101740
Autor:
Ji Liao, Fenghua Hu, Joanna Chin, Alyson E. Fournier, Betty P. Liu, Stephane Budel, Stephen M. Strittmatter
Nogo is a myelin-derived protein that limits axonal regeneration after CNS injury. A short hydrophilic Nogo-66 loop between two hydrophobic domains of Nogo binds to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth. Inhibition of axon outgrowth an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92231e5d87c1dca21f6b3edf38f5b27b
https://europepmc.org/articles/PMC2855126/
https://europepmc.org/articles/PMC2855126/
Autor:
Benxiu Ji, Shuxin Li, Adrienna Jirik, Weiwei Li, Dinah W. Y. Sah, Stephane Budel, Lee Walus, Daniel Lee, Rabacchi Sylvia A, Stephen M. Strittmatter, Jane K. Relton, Mingwei Li, Pepinsky R Blake, Dane S. Worley, Eugene Choi, Betty P. Liu
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(46)
The growth of injured axons in the adult mammalian CNS is limited after injury. Three myelin proteins, Nogo, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), bind to the Nogo-66 receptor (NgR) and inhibit axonal g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f7ed441fa9448d3915d486cfc493f2
https://pubmed.ncbi.nlm.nih.gov/15548666
https://pubmed.ncbi.nlm.nih.gov/15548666
Publikováno v:
Molecular and cellular neurosciences. 29(1)
Axon growth after spinal injury is thought to be limited in part by myelin-derived proteins that act via the Nogo-66 Receptor (NgR). To test this hypothesis, we sought to study recovery from spinal cord injury (SCI) after inhibiting NgR transgenicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3400a36840b40aab9aef5cff5729583b
https://pubmed.ncbi.nlm.nih.gov/15866044
https://pubmed.ncbi.nlm.nih.gov/15866044