Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stephane Betzi"'
Autor:
Julie Piron, Stephane Betzi, Jessica Pastour, Audrey Restouin, Rémy Castellano, Yves Collette, Niklas Tysklind, Juliette Smith-Ravin, Fabienne Priam
Publikováno v:
PeerJ, Vol 10, p e13955 (2022)
Although marine sponges are known for their antimicrobial, antifungal and cytotoxic activity, very few studies have been carried out on endemic species of Martinique. Martinique is part of the Agoa Sanctuary, a marine protected area that includes the
Externí odkaz:
https://doaj.org/article/c6baee5e5c2d46a49ec3a7763d65d782
Autor:
Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Masitinib is a protein kinase inhibitor that sensitises refractory pancreatic adenocarcinoma cells to treatment with the nucleoside analog gemcitabine. Here the authors show that Masitinib activates deoxycytidine kinase to enhance phosphorylation of
Externí odkaz:
https://doaj.org/article/17f65d9ef23b487fb909bb37564ae125
Autor:
Sanne H. Olesen, Donna J. Ingles, Jin-Yi Zhu, Mathew P. Martin, Stephane Betzi, Gunda I. Georg, Joseph S. Tash, Ernst Schönbrunn
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 1643-1660 (2015)
The molecular chaperone Hsp90 is regulated by co-chaperones such as p50Cdc37, which recruits a wide selection of client protein kinases. Targeted disruption of the Hsp90-p50Cdc37 complex by protein–protein interaction (PPI) inhibitors has emerged a
Externí odkaz:
https://doaj.org/article/00296e6254394b5caf006653751a6a7c
Autor:
Laetitia Ganier, Stephane Betzi, Carine Derviaux, Philippe Roche, Charlotte Dessaux, Christophe Muller, Laurent Hoffer, Xavier Morelli, Jean-Paul Borg
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩
ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩
International audience; Second cause of death due to cancer worldwide, colorectal cancer (CRC) is a major public health issue. The discovery of new therapeutic targets is thus essential. The pseudokinase PTK7 intervenes in the regulation of the Wnt/
Autor:
Christophe Muller, Stephane Betzi, Laetitia Ganier, Carine Derviaux, Xavier Morelli, Laurent Hoffer, Philippe Roche, Jean-Paul Borg
Second cause of death due to cancer worldwide, colorectal cancer (CRC) is a major public health issue. The discovery of new therapeutic targets is thus essential. The pseudokinase PTK7 intervenes in the regulation of the Wnt/β-catenin pathway signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::021e982fb79966354fefd7988d69fdea
https://doi.org/10.1101/2021.10.15.464507
https://doi.org/10.1101/2021.10.15.464507
Autor:
Aurélien Thureau, Samir Messaoudi, Christina Sizun, Stephane Betzi, Florian Malard, Jérôme Dejeu, Amélie Chabrier, Naïma Nhiri, Eric Jacquet, Xu Zhang, Ewen Lescop
Publikováno v:
ChemMedChem
ChemMedChem, Wiley-VCH Verlag, In press, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, Wiley-VCH Verlag, 2021, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩
ChemMedChem, Wiley-VCH Verlag, In press, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, Wiley-VCH Verlag, 2021, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩
International audience; TCTP protein is a pharmacological target in cancer and TCTP inhibitors such as sertraline have been evaluated in clinical trials. The direct interaction of TCTP with the drugs sertraline and thioridazine has been reported in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5721da07bbb4e7f1766d65b12a32b4bf
https://hal.archives-ouvertes.fr/pasteur-03370569
https://hal.archives-ouvertes.fr/pasteur-03370569
Autor:
Rudra Kashyap, Karine Barral, Pascale Zimmermann, M. Platonov, Stephane Betzi, Laurent Hoffer, Carine Derviaux, Philippe Roche, Antonio Luis Egea-Jimenez, Rania Ghossoub, Mikael Feracci, M. Garcia, D. Kovalskyy, Raphael Leblanc, Xavier Morelli
Publikováno v:
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Taylor & Francis, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
Journal of Extracellular Vesicles, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
'Journal of Extracellular Vesicles ', vol: 10, pages: e12039-1-e12039-17 (2020)
Journal of Extracellular Vesicles, Taylor & Francis, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
Journal of Extracellular Vesicles, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
'Journal of Extracellular Vesicles ', vol: 10, pages: e12039-1-e12039-17 (2020)
Exosomes support cell-to-cell communication in physiology and disease, including cancer. We currently lack tools, such as small chemicals, capable of modifying exosome composition and activity in a specific manner. Building on our previous understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5734c60859249892f7107ad924881fde
https://hal-amu.archives-ouvertes.fr/hal-03152593
https://hal-amu.archives-ouvertes.fr/hal-03152593
Autor:
Magali Saez-Ayala, Laurent Hoffer, Sébastien Abel, Khaoula Ben Yaala, Benoit Sicard, Guillaume P. Andrieu, Mehdi Latiri, Emma K. Davison, Marco A. Ciufolini, Paul Brémond, Etienne Rebuffet, Philippe Roche, Carine Derviaux, Edwige Voisset, Camille Montersino, Remy Castellano, Yves Collette, Vahid Asnafi, Stéphane Betzi, Patrice Dubreuil, Sébastien Combes, Xavier Morelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools. Deoxycytidine kinase is the rate-limiting enzyme of the salvage pathway and it has r
Externí odkaz:
https://doaj.org/article/455ce64ed58b44c582373ae5edcfa6e5
Autor:
Yuliia V. Voitovich, Aleksey Y. Fedorov, Christophe Muller, Agnès Amouric, Dragos Horvath, Alexandre Varnek, Philippe Roche, Yves Collette, Sébastien Combes, Carine Derviaux, Stephane Betzi, Xavier Morelli, Brigitt Raux, Laurent Hoffer, Kendall Carrasco
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Over the past few decades, hit identification has been greatly facilitated by advances in high-throughput and fragment-based screenings. One major hurdle remaining in drug discovery is process automation of hit-to-lead (H2L) optimization. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afcd74efa86d4fc98ba86edb8f8734e
https://hal.archives-ouvertes.fr/hal-02067797
https://hal.archives-ouvertes.fr/hal-02067797
Autor:
Laurent Gros, Stephane Betzi, Paulo De Sepulveda, Nathalie Casteran, Magali Saez-Ayala, Martine Humbert, Stéphane Audebert, Kahina Hammam, Patrice Dubreuil, Alain Moussy, Sébastien Combes, Etienne Rebuffet, Adrien Lugari, Sébastien Letard, Colin Mansfield, Sophie Lopez, Berengere Hajem, Emilie Baudelet, Xavier Morelli
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
'Nature Communications ', vol: 8, pages: 1420-1-120-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
'Nature Communications ', vol: 8, pages: 1420-1-120-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. Here we report a reverse proteomic approach that identifies the target responsible for this sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736ab0c1b51a55de7df23e88f8a422fb
https://hal.archives-ouvertes.fr/hal-01643359/file/article55.pdf
https://hal.archives-ouvertes.fr/hal-01643359/file/article55.pdf