Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Stephane Bach"'
Autor:
Marwa Dhiabi, Ali Bouattour, Mehdi Fakhfakh, Souhir Abid, Ludovic Paquin, Thomas Robert, Stephane Bach, Jean-Pierre Bazureau, Houcine Ammar
Publikováno v:
Journal of Molecular Structure
Journal of Molecular Structure, 2023, 1274 (Part 1), pp.134319. ⟨10.1016/j.molstruc.2022.134319⟩
Journal of Molecular Structure, 2023, 1274 (Part 1), pp.134319. ⟨10.1016/j.molstruc.2022.134319⟩
International audience; The synthesis of 2-benzylamino-8-methoxy-4 H-chromene-3-carbonitriles 7(a-e) has been realized in four steps, via reductive amination from the 2-amino-8-methoxy-4 H-chromene-3-carbonitrile 4 as key intermediate platform with p
Autor:
Vaia-Argyro Bakalakou, Barbara Mavroidi, Amalia D. Kalampaliki, Béatrice Josselin, Stéphane Bach, Alexios-Leandros Skaltsounis, Panagiotis Marakos, Nicole Pouli, Maria Pelecanou, Vassilios Myrianthopoulos, Sandrine Ruchaud, Ioannis K. Kostakis
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100193- (2024)
In the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potenti
Externí odkaz:
https://doaj.org/article/eb0021815ee9431cabe5edd011eff369
Autor:
Camille Blouet, Stéphanie Letast, Thomas Robert, Stéphane Bach, Noël Pinaud, Nicolas Joubert, Marie-Claude Viaud-Massuard, Jean Guillon, Cédric Logé, Caroline Denevault-Sabourin
Publikováno v:
Molbank, Vol 2023, Iss 4, p M1735 (2023)
Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structu
Externí odkaz:
https://doaj.org/article/eb3c8596c9f24290a70b6f4142e78806
Autor:
Adeline Ribeiro E. Silva, Mamadou Amadou Diallo, Alix Sausset, Thomas Robert, Stéphane Bach, Françoise I. Bussière, Fabrice Laurent, Sonia Lacroix-Lamandé, Anne Silvestre
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Eimeria tenella is an obligate intracellular parasite responsible for avian coccidiosis. Like other apicomplexan parasites, such as Toxoplasma gondii, cell invasion and intracellular development rely on apical organelle content discharge, na
Externí odkaz:
https://doaj.org/article/c33d06594168422facd9ec0abe34b316
Autor:
Sreenivas Avula, Xudan Peng, Xingfen Lang, Micky Tortorella, Béatrice Josselin, Stéphane Bach, Stephane Bourg, Pascal Bonnet, Frédéric Buron, Sandrine Ruchaud, Sylvain Routier, Cleopatra Neagoie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1632-1650 (2022)
A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduct
Externí odkaz:
https://doaj.org/article/eae579ca70af4ec7902f09b889e08fbc
Autor:
Nathalie Desban, Fabienne Gug, Hervé Galons, Cécile Voisset, Marc Blondel, Nassima Oumata, Stephane Bach, Déborah Tribouillard-Tanvier
Publikováno v:
Bioconjugate Chemistry. 21:279-288
The synthesis of affinity matrices for 6-aminophenanthridine (6AP) and 2,6-dichlorobenzylidenaminoguanidine (Guanabenz, GA), two unrelated prion inhibitors, is described. In both cases, the same simple spacer, epsilon-aminocaproylaminopentanol, was i
Autor:
Claire Delehouzé, Arnaud Comte, Stephen Adonai Leon-Icaza, Céline Cougoule, Marcelle Hauteville, Peter Goekjian, Jeannette Chloë Bulinski, Marie-Thérèse Dimanche-Boitrel, Etienne Meunier, Morgane Rousselot, Stéphane Bach
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show her
Externí odkaz:
https://doaj.org/article/bec49c3acc7b48aa983463f7fc23bb1f
Autor:
Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, Béatrice Josselin, Blandine Baratte, Amandine Bescond, Julien Duez, Xavier Fant, Stéphane Bach, Dominique Marie, Matthieu Place, Sami Ben Salah, Agnes Chartier, Sabine Berteina-Raboin, Apirat Chaikuad, Stefan Knapp, Fabrice Carles, Pascal Bonnet, Frédéric Buron, Sylvain Routier, Sandrine Ruchaud
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1840-1853 (2020)
Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relation
Externí odkaz:
https://doaj.org/article/090287ce3ba04ea5ab8ef21466f6dc6b
Autor:
Alessia Caputo, Sara Sartini, Elisabetta Levati, Ilaria Minato, Gian Marco Elisi, Adriana Di Stasi, Catherine Guillou, Peter G. Goekjian, Pierre Garcia, David Gueyrard, Stéphane Bach, Arnaud Comte, Simone Ottonello, Silvia Rivara, Barbara Montanini
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1449 (2022)
Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobial
Externí odkaz:
https://doaj.org/article/7ef6bd0a1f0244f082ea0dce5fc2f98a
Autor:
Patrick Schiavone, Stephane Bach
Publikováno v:
SPIE Proceedings.
In this paper, we describe a new methodology for the determination of Dill parameters based on reflectivity measurements. In opposition to previous methods, samples are produced using the usual process steps. Silicon wafers and standard photoresist c