Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Stephane, Angers"'
Autor:
Nursen Balekoglu, Jean-Francois Michaud, Rachelle Sauvé, Kehinde S. Ayinde, Sichun Lin, Yijun Liu, Daniel A. Kramer, Kaiyue Zhang, Anika Steffen, Theresia Stradal, Stephane Angers, Baoyu Chen, Patricia T. Yam, Frédéric Charron
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111333- (2024)
Summary: During development, Shh attracts axons of spinal cord commissural neurons to the floor plate. Shh-mediated attraction of commissural axons requires the receptor Boc. How Boc regulates cytoskeletal changes in growth cones in response to Shh i
Externí odkaz:
https://doaj.org/article/27b680326d674633831c0206851d2426
Autor:
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress gra
Externí odkaz:
https://doaj.org/article/95ff214a0fa9446fbd3a459e08308533
Autor:
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA polymerase II (Pol II), and t
Externí odkaz:
https://doaj.org/article/29852213a0ff4f3898e31bb9afc0393f
Autor:
Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S459- (2023)
Externí odkaz:
https://doaj.org/article/f0de68d0b5dc43609a5dcbcc8605236a
Autor:
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target whic
Externí odkaz:
https://doaj.org/article/875e347a38ed42f697dc3427cce904d4
Autor:
Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107415- (2023)
Summary: Norrin (NDP) and WNT7A/B induce and maintain the blood-brain and blood-retina barrier (BBB, BRB) by stimulating the Frizzled4-LDL receptor related protein 5/6 (FZD4-LRP5/6) complex to induce beta-catenin-dependent signaling in endothelial ce
Externí odkaz:
https://doaj.org/article/fffa45f051214dd5a60a83b32119997b
Autor:
David N. Philpott, Surath Gomis, Hansen Wang, Randy Atwal, Abdellali Kelil, Tanja Sack, Brandon Morningstar, Chris Burnie, Edward H. Sargent, Stephane Angers, Sachdev Sidhu, Shana O. Kelley
Publikováno v:
ACS Central Science, Vol 8, Iss 1, Pp 102-109 (2021)
Externí odkaz:
https://doaj.org/article/1018965999b24e8ba5d6ffcea7f2789f
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
Autor:
Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-16 (2021)
Abstract The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mu
Externí odkaz:
https://doaj.org/article/823716d920524f3b8debfe84b49df873
Autor:
Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essent
Externí odkaz:
https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7
Autor:
Stephane Angers
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-3 (2021)
Abstract Despite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐
Externí odkaz:
https://doaj.org/article/46d751789d3941cf9f8eea0312b40f33