Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Stephan Wueest"'
Publikováno v:
Adipocyte, Vol 12, Iss 1 (2023)
ABSTRACTThe cytokine interleukin (IL)-27 has been reported to induce thermogenesis in white adipocytes. However, it remains unknown whether IL-27-mediated adipocyte energy dissipation is paralleled by an elevated energy supply from lipids and/or carb
Externí odkaz:
https://doaj.org/article/9cd816ebd43743c6b0ae19717f4525b5
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 315-324 (2022)
Oncostatin M (OSM) is a member of the glycoprotein 130 cytokine family that is involved in chronic inflammation and increased in adipose tissue under obesity and insulin resistance. OSM was shown to inhibit adipogenesis, suppress browning, and contri
Externí odkaz:
https://doaj.org/article/1c46687a47fc4334a59762648a2a8f1b
Autor:
Theresa V. Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the
Externí odkaz:
https://doaj.org/article/80b59b6deb3e496981cc210ada5bc2b9
Autor:
Fabrizio C. Lucchini, Stephan Wueest, Tenagne D. Challa, Flurin Item, Salvatore Modica, Marcela Borsigova, Yulia Haim, Christian Wolfrum, Assaf Rudich, Daniel Konrad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating k
Externí odkaz:
https://doaj.org/article/a5f0fcf02ab1420cbe65f5ab4e73cc5e
Autor:
Troy L. Merry, Chris P. Hedges, Stewart W. Masson, Beate Laube, Doris Pöhlmann, Stephan Wueest, Michael E. Walsh, Myrtha Arnold, Wolfgang Langhans, Daniel Konrad, Kim Zarse, Michael Ristow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty li
Externí odkaz:
https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b5
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 535-541 (2020)
Increasing energy expenditure via induction of browning in white adipose tissue has emerged as a potential strategy to treat obesity and associated metabolic complications. We previously reported that ASK1 inhibition in adipocytes protected from high
Externí odkaz:
https://doaj.org/article/0d43f3fd018043709c85663053d6a064
Autor:
Pim P. van Krieken, Timothy S. Odermatt, Marcela Borsigova, Matthias Blüher, Stephan Wueest, Daniel Konrad
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101341- (2021)
Objective: Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and r
Externí odkaz:
https://doaj.org/article/23a7c0c3560942fbbc72bfa61ba20110
Autor:
Tenagne D Challa, Stephan Wueest, Fabrizio C Lucchini, Mara Dedual, Salvatore Modica, Marcela Borsigova, Christian Wolfrum, Matthias Blüher, Daniel Konrad
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-17 (2019)
Abstract Non‐alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and may progress to non‐alcoholic steatohepatitis (NASH) and liver fibrosis. The deficit of pharmacological therapies for the latter mainly results from an inc
Externí odkaz:
https://doaj.org/article/e34078afbfda453eaefc34f8adc5adcd
Autor:
Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C. Lucchini, Rémy Denzler, Muriel C. Fisser, Tenagne D. Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A. O’Reilly, Markus Stoffel, Johan Auwerx, Daniel Konrad
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and in
Externí odkaz:
https://doaj.org/article/651aa8c22bce4313bef6d51b35cf53ab
Autor:
Stephan Wueest, Eleonora Seelig, Katharina Timper, Mark P. Lyngbaek, Kristian Karstoft, Marc Y. Donath, Helga Ellingsgaard, Daniel Konrad
Publikováno v:
Metabolites, Vol 11, Iss 2, p 79 (2021)
Human obesity is associated with decreased circulating adiponectin and elevated leptin levels. In vitro experiments and studies in high fat diet (HFD)-fed mice suggest that interleukin-6 (IL-6) may regulate adiponectin and leptin release from white a
Externí odkaz:
https://doaj.org/article/c5545c9b729840219e59ca0522f2a93b