Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Stephan Wilmes"'
Autor:
Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Publikováno v:
eLife, Vol 10 (2021)
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Externí odkaz:
https://doaj.org/article/036f2f9b6d674d24920c5291fa65c2f9
Autor:
David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signal
Externí odkaz:
https://doaj.org/article/468ea883eae44e69b79d347c613a8344
Autor:
Daniela Chmiest, Nanaocha Sharma, Natacha Zanin, Christine Viaris de Lesegno, Massiullah Shafaq-Zadah, Vonick Sibut, Florent Dingli, Philippe Hupé, Stephan Wilmes, Jacob Piehler, Damarys Loew, Ludger Johannes, Gideon Schreiber, Christophe Lamaze
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this control
Externí odkaz:
https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f94
Autor:
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Publikováno v:
eLife, Vol 8 (2019)
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to i
Externí odkaz:
https://doaj.org/article/1b051ad15afd4701b89407a5956a40df
Autor:
Eric Herrmann, Jan-Hannes Schäfer, Stephan Wilmes, Christian Ungermann, Arne Moeller, Daniel Kümmel
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The endosomal system of eukaryotic cells represents a central sorting and recycling compartment linked to metabolic signaling and the regulation of cell growth. Tightly controlled activation of Rab GTPases is required to establish the different domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b8c5ebb66df63d7e2432f79b78ab41
https://doi.org/10.1073/pnas.2301908120
https://doi.org/10.1073/pnas.2301908120
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janu
Externí odkaz:
https://doaj.org/article/f04937f580164914880b08b0ceadd2dc
Interleukin 27 (IL-27) is a heterodimeric cytokine that elicits potent immuno-suppressive responses. Comprised of EBI3 and p28 subunits, IL-27 binds GP130 and IL-27Rα receptor chains to activate the JAK/STAT signalling cascade. However, how these re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbbc178bafecde87b8227dc17ae0ff
http://hdl.handle.net/10044/1/98306
http://hdl.handle.net/10044/1/98306
Interleukin 27 (IL-27) is a heterodimeric cytokine that elicits potent immuno-suppressive responses. Comprised of EBI3 and p28 subunits, IL-27 binds GP130 and IL-27Rα receptor chains to activate the JAK/STAT signalling cascade. However, how these re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd1c764dea7c6eb96a87cfb4ee6b62f
https://doi.org/10.1101/2022.02.18.481027
https://doi.org/10.1101/2022.02.18.481027
Autor:
Changjiang You, Florian Eull, Jacob Piehler, Ulrich Rothbauer, Stephan Wilmes, Rainer Kurre, Oliver Birkholz, Hella Kenneweg, Christian Richter, Junel Sotolongo Bellón, Mark R. Walter
Publikováno v:
Cell reports methods. 2(2)
Localization and tracking of individual receptors by single-molecule imaging opens unique possibilities to unravel the assembly and dynamics of signaling complexes in the plasma membrane. For this purpose, we here developed a comprehensive workflow f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9eb340bc57fed8b0d0a3bab267baaf2
https://pubmed.ncbi.nlm.nih.gov/35474965
https://pubmed.ncbi.nlm.nih.gov/35474965
Autor:
Elizabeth Pohler, Ignacio Moraga, Suman Mitra, Martín López-García, Jacob Piehler, Grant Lythe, Stephan Wilmes, Silvia Gaggero, Charles Taylor, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Carmen Molina-París, Maximillian Hafer, T. Guerrier, David Launay, Paul K. Fyfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a345388a0ce6d98b032f01ba82ca9a3
https://doi.org/10.7554/elife.66014.sa2
https://doi.org/10.7554/elife.66014.sa2